The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Serial magnetic resonance scanning in multiple sclerosis: A second prospective study in relapsing patients
Abstract
A prospective study of serial magnetic resonance (MR) scans of the brain was carried out every 2 weeks for 4 to 6 months in 9 patients with mild, clinically definite, relapsing/remitting multiple sclerosis (MS). Six of the 9 patients developed a total of 12 asymptomatic new lesions in various parts of the brain. In none of the patients were the changes on MR scan accompanied by relevant new neurological symptoms or signs. New MR lesions had a characteristic temporal profile, reaching a maximum size in approximately 4 weeks before gradually shrinking, usually leaving a small residual abnormality indistinguishable from chronic MS lesions. The frequent occurrence of new asymptomatic lesions indicates that MS may be a more active process even in mildly affected asymptomatic patients than has been previously realized. The results emphasize the potential importance of using MR scanning to measure disease activity in laboratory studies of MS and in the assessment of treatment, particularly in asymptomatic patients in the early stages. We suggest that the expanding and contracting new lesions are the basic or primary lesion in MS, that the characteristic demyelinated plaque is represented by the small residual area that these lesions shrink down to, and that the typical collection of scattered white matter lesions in chronic MS may represent the accumulated residua of dozens or more of these active lesions occurring over many years.
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Citations
Cites
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011
Paty, D. W., Oger, J. J. F., Kastrukoff, L. F., Hashimoto, S. A., Hooge, J. P., Eisen, A. A., Eisen, K. A., Purves, S. J., Low, M. D., Brandejs, V., et al. (1988) · Neurology · doi:10.1212/wnl.38.2.180 · Cited by 639
Self-citationNUCLEAR MAGNETIC RESONANCE IMAGING OF THE BRAIN IN MULTIPLE SCLEROSIS
Young, I. R., Hall, A. S., Pallis, C. A., Bydder, G. M., Legg, N. J., & Steiner, R. E. (1981) · The Lancet · doi:10.1016/s0140-6736(81)91273-3 · Cited by 470
DIAGNOSIS AND CLASSIFICATION OF MULTIPLE SCLEROSIS
MCDONALD, W. I., & HALLIDAY, A. M. (1977) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a071393 · Cited by 446
Clinical NMR imaging of the brain: 140 cases
Bydder, G., Steiner, R., Young, I., Hall, A., Thomas, D., Marshall, J., Pallis, C., & Legg, N. (1982) · American Journal of Roentgenology · doi:10.2214/ajr.139.2.215 · Cited by 401
Multiple sclerosis: gadolinium enhancement in MR imaging.
Grossman, R. I., Gonzalez-Scarano, F., Atlas, S. W., Galetta, S., & Silberberg, D. H. (1986) · Radiology · doi:10.1148/radiology.161.3.3786722 · Cited by 289
Nuclear magnetic resonance imaging in multiple sclerosis
Lukes, S. A., Crooks, L. E., Aminoff, M. J., Kaufman, L., Panitch, H. S., Mills, C., & Norman, D. (1983) · Annals of Neurology · doi:10.1002/ana.410130603 · Cited by 200
Multiple sclerosis: A serial study using MRI in relapsing patients
Isaac, C., B. Li, D. K., Genton, M., Jardine, C., Grochowski, E., Palmer, M., Kastrukoff, L. F., Oger, J., & Paty, D. W. (1988) · Neurology · doi:10.1212/wnl.38.10.1511 · Cited by 189
Self-citationPoser, C. M. (1985) · JAMA · doi:10.1001/jama.1985.03360140159046 · Cited by 113
Multiple sclerosis disease activity correlates with gadolinium‐enhanced magnetic resonance imaging
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Cited by
Miller, D. H., Albert, P. S., Barkhof, F., Francis, G., Frank, J. A., Hodgkinson, S., Lublin, F. D., Paty, D. W., Reingold, S. C., & Simon, J. (1996) · Annals of Neurology · doi:10.1002/ana.410390104 · Cited by 444
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Karussis, D. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.01.022 · Cited by 366
Smith, K. J., & McDonald, W. I. (1999) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1999.0510 · Cited by 340
Werring, D. J. (2000) · Brain · doi:10.1093/brain/123.8.1667 · Cited by 326
Metadata
- Authors
- Willoughby, E. W., Grochowski, E., Li, D. K. B., Oger, J., Kastrukoff, L. F., & Paty, D. W.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1989-01
- Volume
- 25
- Issue
- 1
- Pages
- 43-49
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2066433792
- Cited by
- 254
- References
- 13
- FWCI
- 18.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Serial magnetic resonance scanning in multiple sclerosis: A second prospective study in relapsing patients. https://app.cochat.ai/papers/10.1002/ana.410250107
- The paper
- Willoughby, E. W., Grochowski, E., Li, D. K. B., Oger, J., Kastrukoff, L. F., & Paty, D. W. (1989). Serial magnetic resonance scanning in multiple sclerosis: A second prospective study in relapsing patients. Annals of Neurology. https://doi.org/10.1002/ana.410250107
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
