Cited by 382Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolismNuclear Receptors and Signaling

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An introduction to the free radical hypothesis in Parkinson's disease

Olanow, C. W.·1992·Annals of Neurology

DOI 10.1002/ana.410320703

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Abstract

Iron-induced oxidant stress has been implicated in the pathogenesis of Parkinson's disease. An increasing body of evidence now indicates that in Parkinson's disease the environment within the substantia nigra is conducive to the formation of cytotoxic free radicals and cell degeneration. Dopamine neurons may be particularly vulnerable because of the oxidative metabolism of dopamine and the potential of neuromelanin to promote the site-specific accumulation and reduction of iron. This hypothesis has attracted considerable attention because it opens the way for employing antioxidant strategies as possible neuroprotective treatment for Parkinson's disease. Although the concept is appealing, free radicals have not yet been proven to play a role in Parkinson's disease, and many important issues remain to be resolved before the oxidative hypothesis can ultimately be confirmed or refuted.

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Superoxide Dismutase
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Oxygen toxicity, oxygen radicals, transition metals and disease
Halliwell, B., & Gutteridge, J. M. C. (1984) · Biochemical Journal · doi:10.1042/bj2190001 · Cited by 5,330
Mitochondrial DNA and human evolution
Cann, R. L., Stoneking, M., & Wilson, A. C. (1987) · Nature · doi:10.1038/325031a0 · Cited by 3,100
Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts
Halliwell, B., & Gutteridge, J. M. C. (1986) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(86)90305-x · Cited by 2,038
DNA damage and oxygen radical toxicity
Imlay, J. A., & Linn, S. (1988) · Science · doi:10.1126/science.3287616 · Cited by 1,974
Oxygen radicals and human disease
CROSS, C. E., HALLIWELL, B., BORISH, E. T., PRYOR, W. A., AMES, B. N., SAUL, R. L., McCORD, J. M., & HARMAN, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-526 · Cited by 1,856
MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE
Schapira, A. H. V., Cooper, J. A. D., Dexter, D. T., Jenner, P. G., Clark, J. B., & MARSDEN, C. D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92366-0 · Cited by 1,757
The effect of age on the non-haemin iron in the human brain
Hallgren, B., & Sourander, P. (1958) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1958.tb12607.x · Cited by 1,427
Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease
Dexter, D. T., Carter, C. J., Wells, F. R., Javoy-Agid, F., Agid, Y., Lees, A. J., Jenner, P. G., & MARSDEN, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09133.x · Cited by 1,397
Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
Riederer, P., Sofic, E., Rausch, W., Schmidt, B., Reynolds, G. P., Jellinger, K., & Youdim, M. B. H. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09150.x · Cited by 1,383

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Research works printed but not linked: 14

Halliwell, 1985, TINS, 8, 22
Cohen, 1990, Neural Transm, 32, 229
Olanow, 1990, Neurology, 40, 32
Halliwell, 1988, ISI Atlas Sci Biochem, 1, 48
Potts, 1976, Exp Eye Res, 48, 221
Sarna, 1976, Science, 1132, 192
Brain iron: MRI studies in Parkinson's syndrome. In: eds. Florham Park, New Jersey: MacMillan Healthcare, 1987: 135-143
Sengstock, 1991, Movement Dis, 6, 272
Olanow, 1991, Neurology, 42, 13
Riederer, 1989, J Neurochem, 52, 515, 10.1111/j.1471-4159.1989.tb09150.x · DOI · Paper page
Good, 1992, J Neuropathol Exp Neurol, 51, 327
et al. Vitamin E levels in brain are not altered in Parkinson's disease. Ann Neurol 1992 (in press)
et al. Brain skeletal muscle and platelet mitochondrial function in Parkinson's disease. Brain 1992 (in press)
Spina, 1988, J Pharmacol Exp Ther, 247, 502

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Self-citation
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Diehl, L. A., Pereira, N. D. S. C., Laureano, D. P., Benitz, A. N. D., Noschang, C. G., Ferreira, A. G. K., Scherer, E. B. D. S., Machado, F. R., Henriques, T. P., Wyse, Â. T. D. S., et al. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1230-x · Cited by 43
Novel 2-substituted nitronyl nitroxides as free radical scavengers: Synthesis, biological evaluation and structure–activity relationship
Wu, Y., Bi, L., Bi, W., Zeng, L., Zhao, M., Wang, C., Ju, J., & Peng, S. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.04.016 · Cited by 38
Simple isatin derivatives as free radical scavengers: Synthesis, biological evaluation and structure-activity relationship
Chen, G., Wang, Y., Hao, X., Mu, S., & Sun, Q. (2011) · Chemistry Central Journal · doi:10.1186/1752-153x-5-37 · Cited by 38
Medical treatment of Parkinson’s disease
Fahn, S. (1998) · Journal of Neurology · doi:10.1007/pl00007742 · Cited by 38
Early Parkinson??s Disease
Hristova, A. H., & Koller, W. C. (2000) · Drugs & Aging · doi:10.2165/00002512-200017030-00002 · Cited by 38
Absence of Mutations in Superoxide Dismutase and Catalase Genes in Patients With Parkinson's Disease
Parboosingh, J. S., Rousseau, M., Rogan, F., Amit, Z., Chertkow, H. M., Johnson, W. G., Manganaro, F., Schipper, H., Curran, T. J., Stoessl, A. J., et al. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540360038013 · Cited by 38
Interactions between free radicals and a graphene fragment: Physical versus chemical bonding, charge transfer, and deformation
Wang, F. T., Chen, L., Tian, C., Yan, M., Wang, Z., Zhang, R. Q., Jin, M., Zhang, P., & Ding, D. (2011) · Journal of Computational Chemistry · doi:10.1002/jcc.21910 · Cited by 37
Hydrogen Peroxide and Amyotrophic Lateral Sclerosis: From Biochemistry to Pathophysiology
Sanghai, N., & Tranmer, G. K. (2021) · Antioxidants · doi:10.3390/antiox11010052 · Cited by 37
Oxidative stress and age-related neuronal deficits
Joseph, J. A., Denisova, N., Villalobos‐Molina, R., Erat, S., & Strain, J. G. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815202 · Cited by 37
Intracellular glutathione levels determine cerebellar granule neuron sensitivity to excitotoxic injury by kainic acid
Ceccon, M., Giusti, P., Facci, L., Borin, G., Imbesi, M., Floreani, M., & Skaper, S. D. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02074-6 · Cited by 36
Polymorphisms of the Parkin Gene in Sporadic Parkinson’s Disease among Chinese in Taiwan
Hu, C., Sung, S., Liu, H., Lee, C.-C., Tsai, C., & Chang, J. (2000) · European Neurology · doi:10.1159/000008203 · Cited by 36
Intranuclear inclusions in oculopharyngeal muscular dystrophy among Bukhara Jews
Blumen, S. C., Sadeh, M., Korczyn, A. D., Rouche, A., Nisipeanu, P., Asherov, A., & Tomé, F. M. S. (1996) · Neurology · doi:10.1212/wnl.46.5.1324 · Cited by 36
Cerebrospinal fluid of Parkinson's disease patients inhibits the growth and function of dopaminergic neurons in culture
Hao, R., Norgren, R. B., Lau, Y., & Pfeiffer, R. F. (1995) · Neurology · doi:10.1212/wnl.45.1.138 · Cited by 35
Enhancement of cytotoxicity and clastogenicity of l-DOPA and dopamine by manganese and copper
Snyder, R. D., & Friedman, M. B. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(98)00117-1 · Cited by 34
Cellular Models to Study Dopaminergic Injury Responses
Collier, T. J., Steece‐Collier, K., McGuire, S. O., & Sortwell, C. E. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07472.x · Cited by 34
Antioxidant and pro-oxidant capacity of catecholamines and related compounds. Effects of hydrogen peroxide on glutathione and sphingomyelinase activity in pheochromocytoma PC12 cells: potential relevance to age-related diseases
Sofic, E., Denisova, N., Youdim, K. A., Vatrenjak-Velagic, V., Filippo, C. D., Mehmedagić, A., Causevic, A., Cao, G., Joseph, J. A., & Prior, R. L. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170055 · Cited by 34
Pathological evidence for oxidative stress in Parkinson's disease and related degenerative disorders
Jenner, P. G., & Olanow, C. W. (1996) · Elsevier eBooks · doi:10.1016/b978-012525445-8/50004-7 · Cited by 34
Self-citation
Effects of early life interventions and palatable diet on anxiety and on oxidative stress in young rats
Marcolin, M. L., Benitz, A. N. D., Arcego, D. M., Noschang, C. G., Krolow, R., & Dalmaz, C. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.03.025 · Cited by 33
Exacerbation of iminodipropionitrile-induced behavioral toxicity, oxidative stress, and vestibular hair cell degeneration by gentamicin in rats
Deeb, S. A., Moutaery, K. A., Khan, H. A., & Tariq, M. (2000) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(99)00075-6 · Cited by 33
Association of endothelial nitric oxide synthase and mitochondrial dysfunction in the hippocampus of scrapie‐infected mice
Park, J., Kim, B., Park, S., Jin, J., Jeon, Y., Wen, G. Y., Shin, H., Carp, R. I., & Kim, Y. (2010) · Hippocampus · doi:10.1002/hipo.20753 · Cited by 33
Stimulation of total phenolics, L-DOPA and antioxidant activity through proline-linked pentose phosphate pathway in response to proline and its analogue in germinating fava beans (Vicia faba)
Shetty, P., Atallah, M. T., & Shetty, K. (2003) · Process Biochemistry · doi:10.1016/s0032-9592(02)00257-1 · Cited by 33
1-Methyl-1,2,3,4-tetrahydroisoquinoline Antagonizes a Rise in Brain Dopamine Metabolism, Glutamate Release in Frontal Cortex and Locomotor Hyperactivity Produced by MK-801 but not the Disruptions of Prepulse Inhibition, and Impairment of Working Memory in Rat
Pietraszek, M., Michaluk, J., Romańska, I., Wąsik, A., Gołembiowska, K., & Antkiewicz‐Michaluk, L. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9097-y · Cited by 33
Hypoxia-induced mitochondrial and nuclear DNA damage in the rat brain
Englander, E. W., Greeley, G. H., Wang, G., Perez-Polo, J. R., & Lee, H.-M. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19991015)58:2 · Cited by 51
The Effects of Hydroxyl Radical Attack on Dopa, Dopamine, 6‐Hydroxydopa, and 6‐Hydroxydopamine
Nappi, A. J., Vass, E., Prota, G., & Memoli, S. (1995) · Pigment Cell Research · doi:10.1111/j.1600-0749.1995.tb00676.x · Cited by 33
Therapeutic Potential of AMPA Receptor Ligands in Neurological Disorders
Lees, G. J. (1996) · CNS Drugs · doi:10.2165/00023210-199605010-00005 · Cited by 33

Authors: Olanow, C. W.
Affiliations: University of South Florida (US)
Corresponding author: Olanow, C. W.
ORCID: Olanow, C. W.
Venue: Annals of Neurology
Publisher: Wiley
Published: 1992
Volume: 32
Issue: S1
Pages: S2-S9
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.410320703
OpenAlex: W2156259977
Cited by: 382
References: 68
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 13
FWCI: 3.32
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 8644 d)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: Parkinson's disease, oxidative stress, iron accumulation, substantia nigra, dopaminergic neurons, neuromelanin, dopamine oxidation, neuroprotection, antioxidants, neurodegeneration
MeSH terms: Animals, Free Radicals, Humans, Iron, Parkinson Disease, Substantia Nigra, Lipid Peroxidation

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An introduction to the free radical hypothesis in Parkinson's disease

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