The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Degradable Molybdenum Oxide Nanosheets with Rapid Clearance and Efficient Tumor Homing Capabilities as a Therapeutic Nanoplatform
Abstract
Molybdenum oxide (MoOx) nanosheets with high near‐infrared (NIR) absorbance and pH‐dependent oxidative degradation properties were synthesized, functionalized with polyethylene glycol (PEG), and then used as a degradable photothermal agent and drug carrier. The nanosheets, which are relatively stable under acidic pH, could be degraded at physiological pH. Therefore, MoOx‐PEG distributed in organs upon intravenous injection would be rapidly degraded and excreted without apparent in vivo toxicity. MoOx‐PEG shows efficient accumulation in tumors, the acidic pH of which then leads to longer tumor retention of those nanosheets. Along with the capability of acting as a photothermal agent for effective tumor ablation, MoOx‐PEG can load therapeutic molecules with high efficiencies. This concept of inorganic theranostic nanoagent should be relatively stable in tumors to allow imaging and treatment, while being readily degradable in normal organs to enable rapid excretion and avoid long‐term retention/toxicity.
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Self-citationUltrasmall Reduced Graphene Oxide with High Near-Infrared Absorbance for Photothermal Therapy
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Self-citationDrug Delivery with PEGylated MoS2 Nano‐sheets for Combined Photothermal and Chemotherapy of Cancer
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Self-citationUltrasmall Black Phosphorus Quantum Dots: Synthesis and Use as Photothermal Agents
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Cited by
Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy
Song, G., Cheng, L., Chao, Y., Yang, K., & Liu, Z. (2017) · Advanced Materials · doi:10.1002/adma.201700996 · Cited by 771
Self-citationInorganic nanomaterials with rapid clearance for biomedical applications
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Metadata
- Authors
- Song, G., Hao, J., Liang, C., Liu, T., Gao, M., Cheng, L., Hu, J., & Liu, Z.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2015-12-28
- Volume
- 55
- Issue
- 6
- Pages
- 2122-2126
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2219892614
- Cited by
- 299
- References
- 26
- FWCI
- 16.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Song, G., Hao, J., Liang, C., Liu, T., Gao, M., Cheng, L., Hu, J., & Liu, Z. (2016). Degradable Molybdenum Oxide Nanosheets with Rapid Clearance and Efficient Tumor Homing Capabilities as a Therapeutic Nanoplatform. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201510597
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