The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Nonribosomal Peptide Synthesis—Principles and Prospects
Abstract
Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that assemble numerous peptides with large structural and functional diversity. These peptides include more than 20 marketed drugs, such as antibacterials (penicillin, vancomycin), antitumor compounds (bleomycin), and immunosuppressants (cyclosporine). Over the past few decades biochemical and structural biology studies have gained mechanistic insights into the highly complex assembly line of nonribosomal peptides. This Review provides state‐of‐the‐art knowledge on the underlying mechanisms of NRPSs and the variety of their products along with detailed analysis of the challenges for future reprogrammed biosynthesis. Such a reprogramming of NRPSs would immediately spur chances to generate analogues of existing drugs or new compound libraries of otherwise nearly inaccessible compound structures.
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Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
RING Domain E3 Ubiquitin Ligases
Deshaies, R. J., & Joazeiro, C. A. P. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.101807.093809 · Cited by 2,679
Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells
Nougayrède, J.-P., Homburg, S., Taieb, F., Boury, M., Brzuszkiewicz, E., Gottschalk, G., Buchrieser, C., Hacker, J., Dobrindt, U., & Oswald, E. (2006) · Science · doi:10.1126/science.1127059 · Cited by 1,188
Contemporary strategies for peptide macrocyclization
White, C. J., & Yudin, A. K. (2011) · Nature Chemistry · doi:10.1038/nchem.1062 · Cited by 1,088
Human commensals producing a novel antibiotic impair pathogen colonization
Zipperer, A., Konnerth, M. C., Laux, C., Berscheid, A., Janek, D., Weidenmaier, C., Burian, M., Schilling, N. A., Slavetinsky, C., Marschal, M., et al. (2016) · Nature · doi:10.1038/nature18634 · Cited by 938
Enterobactin: an archetype for microbial iron transport.
Raymond, K. N., Dertz, E. A., & Kim, S. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630018100 · Cited by 933
Quadri, L. E. N., Weinreb, P. H., Lei, M., Nakano, M. M., Zuber, P., & Walsh, C. T. (1998) · Biochemistry · doi:10.1021/bi9719861 · Cited by 693
Murein (peptidoglycan) structure, architecture and biosynthesis in Escherichia coli
Vollmer, W., & Bertsche, U. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.06.007 · Cited by 451
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Translation-Targeting RiPPs and Where to Find Them
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Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament
Sutherland, E., Harding, C. J., du Monceau de Bergendal, T., Florence, G. J., Ackermann, K., Bode, B. E., Synowsky, S., Sundaramoorthy, R., & Czekster, C. M. (2025) · Nature Communications · doi:10.1038/s41467-025-56127-y · Cited by 2
Dey, R., Valle, D. O., Chakraborty, A., Mayer, K. A., Uppala, J. K., Chakraborty, A., Mirza, S., Skwor, T., Forst, S., & Dey, M. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1560663 · Cited by 1
NMR as a readout to monitor and restore the integrity of complex chemoenzymatic reactions
Marincin, K. A., Hwang, Y., Kengmana, E. S., Meyers, D. J., & Frueh, D. P. (2022) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2022.107265
Metadata
- Authors
- Süssmuth, R. D., & Mainz, A.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2017-03-21
- Volume
- 56
- Issue
- 14
- Pages
- 3770-3821
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2602946330
- Cited by
- 958
- References
- 8
- FWCI
- 39.08
- Type
- journal article
- Language
- en
- Open access
- closed
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