The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Enhanced Photodynamic Therapy by Reduced Levels of Intracellular Glutathione Obtained By Employing a Nano‐MOF with CuII as the Active Center
Abstract
In photodynamic therapy (PDT), the level of reactive oxygen species (ROS) produced in the cell directly determines the therapeutic effect. Improvement in ROS concentration can be realized by reducing the glutathione (GSH) level or increasing the amount of photosensitizer. However, excessive amounts photosensitizer may cause side effects. Therefore, the development of photosensitizers that reduce GSH levels through synergistically improving ROS concentration in order to strengthen the efficacy of PDT for tumor is important. We report a nano‐metal–organic framework (Cu II‐metalated nano‐MOF {CuL‐[AlOH]2}n (MOF‐2, H 6 L=mesotetrakis(4‐carboxylphenyl)porphyrin)) based on Cu II as the active center for PDT. This MOF‐2 is readily taken up by breast cancer cells, and high levels of ROS are generated under light irradiation. Meanwhile, intracellular GSH is considerably decreased owing to absorption on MOF‐2; this synergistically increases ROS concentration and accelerates apoptosis, thereby enhancing the effect of PDT. Notably, based on the direct adsorption of GSH, MOF‐2 showed a comparable effect with the commercial antitumor drug camptothecin in a mouse breast cancer model. This work provides strong evidence for MOF‐2 as a promising new PDT candidate and anticancer drug.
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Cited by
Niu, B., Liao, K., Zhou, Y., Wen, T., Quan, G., Pan, X., & Wu, C. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121110 · Cited by 1,168
Wang, C., Cao, F., Ruan, Y., Jia, X., Zhen, W., & Jiang, X. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201903981 · Cited by 411
A Mn(III)-Sealed Metal–Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics
Wan, S.-S., Cheng, Q., Zeng, X., & Zhang, X.-Z. (2019) · ACS Nano · doi:10.1021/acsnano.9b00300 · Cited by 322
Multifunctional metal–organic framework heterostructures for enhanced cancer therapy
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Endogenous Hydrogen Sulfide-Triggered MOF-Based Nanoenzyme for Synergic Cancer Therapy
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Metadata
- Authors
- Zhang, W., Lu, J., Gao, X., Li, P., Zhang, W., Ma, Y., Wang, H., & Tang, B.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2018-03-23
- Volume
- 57
- Issue
- 18
- Pages
- 4891-4896
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2791342926
- Cited by
- 328
- References
- 37
- FWCI
- 30.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, W., Lu, J., Gao, X., Li, P., Zhang, W., Ma, Y., Wang, H., & Tang, B. (2018). Enhanced Photodynamic Therapy by Reduced Levels of Intracellular Glutathione Obtained By Employing a Nano‐MOF with CuII as the Active Center. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201710800
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