The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Dopamine, Oxidative Stress and Protein–Quinone Modifications in Parkinson's and Other Neurodegenerative Diseases
Abstract
Dopamine (DA) is the most important catecholamine in the brain, as it is the most abundant and the precursor of other neurotransmitters. Degeneration of nigrostriatal neurons of substantia nigra pars compacta in Parkinson's disease represents the best‐studied link between DA neurotransmission and neuropathology. Catecholamines are reactive molecules that are handled through complex control and transport systems. Under normal conditions, small amounts of cytosolic DA are converted to neuromelanin in a stepwise process involving melanization of peptides and proteins. However, excessive cytosolic or extraneuronal DA can give rise to nonselective protein modifications. These reactions involve DA oxidation to quinone species and depend on the presence of redox‐active transition metal ions such as iron and copper. Other oxidized DA metabolites likely participate in post‐translational protein modification. Thus, protein–quinone modification is a heterogeneous process involving multiple DA‐derived residues that produce structural and conformational changes of proteins and can lead to aggregation and inactivation of the modified proteins.
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Cites
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Self-citationThe locus coeruleus and noradrenergic modulation of cognition
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Self-citationMelanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
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Cited by
The Role of Oxidative Stress in Parkinson’s Disease
Chang, K.-H., & Chen, C.-M. (2020) · Antioxidants · doi:10.3390/antiox9070597 · Cited by 341
The Glutathione System in Parkinson’s Disease and Its Progression
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Metadata
- Authors
- Monzani, E., Nicolis, S., Dell'Acqua, S., Capucciati, A., Bacchella, C., Zucca, F. A., Mosharov, E. V., Sulzer, D., Zecca, L., & Casella, L.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-03-21
- Volume
- 58
- Issue
- 20
- Pages
- 6512-6527
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2905515525
- Cited by
- 271
- References
- 26
- FWCI
- 13.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Monzani, E., Nicolis, S., Dell'Acqua, S., Capucciati, A., Bacchella, C., Zucca, F. A., Mosharov, E. V., Sulzer, D., Zecca, L., & Casella, L. (2019). Dopamine, Oxidative Stress and Protein–Quinone Modifications in Parkinson's and Other Neurodegenerative Diseases. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201811122
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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