Cited by 376Extracellular vesicles in diseaseNanoplatforms for cancer theranosticsPhagocytosis and Immune Regulation

Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

Nie, Weidong, Wu, Guanghao, Zhang, Jinfeng, Huang, Li‐Li, Ding, Jingjing, Jiang, Anqi, Zhang, Yahui, Liu, Yanhong +3 more·2020·Angewandte Chemie International Edition

Abstract

Exosomes hold great potential in therapeutic development. However, native exosomes usually induce insufficient effects in vivo and simply act as drug delivery vehicles. Herein, we synthesize responsive exosome nano-bioconjugates for cancer therapy. Azide-modified exosomes derived from M1 macrophages are conjugated with dibenzocyclooctyne-modified antibodies of CD47 and SIRPα (aCD47 and aSIRPα) through pH-sensitive linkers. After systemic administration, the nano-bioconjugates can actively target tumors through the specific recognition between aCD47 and CD47 on the tumor cell surface. In the acidic tumor microenvironment, the benzoic-imine bonds of the nano-bioconjugates are cleaved to release aSIRPα and aCD47 that can, respectively, block SIRPα on macrophages and CD47, leading to abolished "don't eat me" signaling and improved phagocytosis of macrophages. Meanwhile, the native M1 exosomes effectively reprogram the macrophages from pro-tumoral M2 to anti-tumoral M1.

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Crossref · 10.1002/anie.201912524

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Authors
Nie, W., Wu, G., Zhang, J., Huang, L., Ding, J., Jiang, A., Zhang, Y., Liu, Y., Li, J., Pu, K., & Xie, H.
Affiliations
  • Beijing Institute of Technology (CN)
  • Chinese Academy of Sciences (CN)
  • School of Chemical and Biomedical Engineering Nanyang Technological University 70 Nanyang Drive Singapore 637457 Singapore
  • Nanyang Technological University (SG)
  • School of Life Science Beijing Institute of Technology Beijing 100081 P. R. China
Corresponding author
Pu, Kanyi
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2019-12-18
Volume
59
Issue
5
Pages
2018-2022
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2991079475
Cited by
376
References
56
Citations by year
2026: 39 · 2025: 52 · 2024: 69 · 2023: 71 · 2022: 65 · 2021: 52 · 2020: 28
FWCI
11.99
Type
journal article
Language
en
Open access
closed
Locations
  • Angewandte Chemie International Edition (publishedVersion)
  • PubMed (publishedVersion)
  • DR-NTU (Nanyang Technological University) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords
exosomes, cancer therapy, CD47, SIRPα, M1 macrophages, macrophage reprogramming, tumor microenvironment, tumor targeting, phagocytosis, macrophage polarization
MeSH terms
Humans, Immunotherapy, Neoplasms, Nanotechnology, Exosomes

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