The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Ligand‐Dependent Activity Engineering of Glutathione Peroxidase‐Mimicking MIL‐47(V) Metal–Organic Framework Nanozyme for Therapy
Abstract
Glutathione peroxidase (GPx) plays an important role in maintaining the reactive oxygen metabolic balance, yet limited GPx‐mimicking nanozymes are currently available for in vivo therapy. Herein, a ligand engineering strategy is developed to modulate the GPx‐mimicking activity of a metal–organic framework (MOF) nanozyme. With different substituted ligands, the GPx‐mimicking activities of MIL‐47(V)‐X (MIL stands for Materials of Institute Lavoisier; X=F, Br, NH 2, CH 3, OH, and H) MOFs are rationally regulated. With the best one as an example, both in vitro and in vivo experiments reveal the excellent antioxidation ability of MIL‐47(V)‐NH 2, which alleviates the inflammatory response effectively for both ear injury and colitis, and is more active than MIL‐47(V). This study proves that high‐performance GPx‐mimicking nanozymes can be rationally designed by a ligand engineering strategy, and that structure–activity relationships can direct the in vivo therapy. This study enriches nanozyme research and expands the range of biomimetic MOFs.
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Cites
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
Gao, L., Zhuang, J., Nie, L., Zhang, J., Zhang, Y., Gu, N., Wang, T., Feng, J., Yang, D., Perrett, S., et al. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.260 · Cited by 7,483
Self-citationROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
Alternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197
Lubos, E., Loscalzo, J., & Handy, D. E. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3586 · Cited by 1,280
Cited by
Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes
Chao, D., Dong, Q., Yu, Z., Qi, D., Li, M., Xu, L., Liu, L., Fang, Y., & Dong, S. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c09663 · Cited by 317
Zhang, Y., Li, G., Zhang, X., & Lin, L. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00667g · Cited by 29
Metadata
- Authors
- Wu, J., Yu, Y., Cheng, Y., Cheng, C., Zhang, Y., Jiang, B., Zhao, X., Miao, L., & Wei, H.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-11-24
- Volume
- 60
- Issue
- 3
- Pages
- 1227-1234
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3092124213
- Cited by
- 224
- References
- 4
- FWCI
- 10.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Wu, J., Yu, Y., Cheng, Y., Cheng, C., Zhang, Y., Jiang, B., Zhao, X., Miao, L., & Wei, H. (2021). Ligand‐Dependent Activity Engineering of Glutathione Peroxidase‐Mimicking MIL‐47(V) Metal–Organic Framework Nanozyme for Therapy. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202010714
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