The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Bone's mechanostat: A 2003 update
Abstract
The still‐evolving mechanostat hypothesis for bones inserts tissue‐level realities into the former knowledge gap between bone's organ‐level and cell‐level realities. It concerns load‐bearing bones in postnatal free‐living bony vertebrates, physiologic bone loading, and how bones adapt their strength to the mechanical loads on them. Voluntary mechanical usage determines most of the postnatal strength of healthy bones in ways that minimize nontraumatic fractures and create a bone‐strength safety factor. The mechanostat hypothesis predicts 32 things that occur, including the gross anatomical bone abnormalities in osteogenesis imperfecta; it distinguishes postnatal situations from baseline conditions at birth; it distinguishes bones that carry typical voluntary loads from bones that have other chief functions; and it distinguishes traumatic from nontraumatic fractures. It provides functional definitions of mechanical bone competence, bone quality, osteopenias, and osteoporoses. It includes permissive hormonal and other effects on bones, a marrow mediator mechanism, some limitations of clinical densitometry, a cause of bone “mass” plateaus during treatment, an “adaptational lag” in some children, and some vibration effects on bones. The mechanostat hypothesis may have analogs in nonosseous skeletal organs as well. Anat Rec Part A 275A:1081–1101, 2003. © 2003 Wiley‐Liss, Inc.
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Cites
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Weaver, C. M., Gordon, C. M., Janz, K. F., Kalkwarf, H. J., Lappe, J. M., Lewis, R., O’Karma, M., Wallace, T. C., & Zemel, B. S. (2016) · Osteoporosis International · doi:10.1007/s00198-015-3440-3 · Cited by 1,378
Estrogens and androgens in skeletal physiology and pathophysiology
Almeida, M., Laurent, M. R., Dubois, V., Claessens, F., O'Brien, C. A., Bouillon, R., Vanderschueren, D., & Manolagas, S. C. (2017) · Physiological Reviews · doi:10.1152/physrev.00033.2015 · Cited by 860
From space to Earth: Advances in human physiology from 20 years of bed rest studies (1986–2006)
Pavy-Le Traon, A., Heer, M., Narici, M. V., Rittweger, J., & Vernikos, J. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0474-z · Cited by 658
Exercise and Bone Mass in Adults
Guadalupe-Grau, A., Fuentes, T., Guerra, B., & Calbet, J. A. L. (2009) · Sports Medicine · doi:10.2165/00007256-200939060-00002 · Cited by 397
RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling
Tobeiha, M., Moghadasian, M. H., Amin, N., & Jafarnejad, S. (2020) · BioMed Research International · doi:10.1155/2020/6910312 · Cited by 309
Metadata
- Authors
- Frost, H. M.
- Venue
- The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology
- Publisher
- Wiley
- Published
- 2003-11-03
- Volume
- 275A
- Issue
- 2
- Pages
- 1081-1101
- ISSN
- 1552-4884 (ISSN-L)
- 1552-4892
- OpenAlex
- W2024916097
- Cited by
- 1,535
- References
- 8
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- closed
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