RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling

Osteoclast differentiation and activation

Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · cited 1× · see citing works

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439 · see citing works

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130 · see citing works

Hip fractures in the elderly: A world-wide projection

Cooper, C. C., Campion, G., & Melton, L. J. (1992) · Osteoporosis International · doi:10.1007/bf01623184 · Cited by 3,225 · see citing works

Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.

Bucay, N., Sarosi, I., Dunstan, C. R., Morony, S., Tarpley, J., Capparelli, C., Scully, S., Tan, H. L., Xu, W., Lacey, D. L., et al. (1998) · Genes & Development · doi:10.1101/gad.12.9.1260 · Cited by 2,483 · see citing works

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044 · see citing works

Bone Morphogenetic Proteins

Chen, D., Zhao, M., & Mundy, G. R. (2004) · Growth Factors · doi:10.1080/08977190412331279890 · Cited by 1,921 · see citing works

Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

Takayanagi, H. (2007) · Nature Reviews Immunology · doi:10.1038/nri2062 · Cited by 1,878 · see citing works

Functions of RANKL/RANK/OPG in bone modeling and remodeling

Boyce, B. F., & Xing, L. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.018 · Cited by 1,844 · see citing works

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778 · see citing works

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.

Hsu, H., Lacey, D. L., Dunstan, C. R., Solovyev, I., Colombero, A., Timms, E., Tan, H.-L., Elliott, G., Kelley, M. J., Sarosi, I., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3540 · Cited by 1,636 · see citing works

Reaching a Genetic and Molecular Understanding of Skeletal Development

Karsenty, G., & Wagner, E. F. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00157-0 · Cited by 1,594 · see citing works

Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation.

Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.017 · Cited by 1,558 · see citing works

Bone's mechanostat: A 2003 update

Frost, H. M. (2003) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.10119 · Cited by 1,540 · see citing works

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingPreprint

Lomaga, M. A., Yeh, W., Sarosi, I., Duncan, G. S., Furlonger, C. L., Ho, A. P., Morony, S., Capparelli, C., Van, G. Y., Kaufman, S., et al. (1999) · Genes & Development · doi:10.1101/gad.13.8.1015 · Cited by 1,253 · see citing works

RANKL–RANK signaling in osteoclastogenesis and bone disease

Wada, T., Nakashima, T., Nishina, H., & Penninger, J. M. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.11.007 · Cited by 1,207 · see citing works

Effects of mechanical forces on maintenance and adaptation of form in trabecular bone

Huiskes, R., Ruimerman, R. R., van Lenthe, H., & Janssen, J. J. (2000) · Nature · doi:10.1038/35015116 · Cited by 1,180 · see citing works

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis, and regulation of bone mass and calcium metabolism.

Li, J., Sarosi, I., Yan, X.-Q., Morony, S., Capparelli, C., Tan, H.-L., McCabe, S., Elliott, R., Scully, S., Van, G., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1566 · Cited by 1,119 · see citing works

Exercise for preventing and treating osteoporosis in postmenopausal women

Howe, T. E., Shea, B., Dawson, L., Downie, F., Murray, A., Ross, C., Harbour, R., Caldwell, L. M., & Creed, G. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000333.pub2 · Cited by 1,090 · see citing works

Clinical Implications of the Osteoprotegerin/RANKL/RANK System for Bone and Vascular Diseases

Hofbauer, L. C. (2004) · JAMA · doi:10.1001/jama.292.4.490 · Cited by 979 · see citing works

Biology of RANK, RANKL, and osteoprotegerin

Boyce, B. F., & Xing, L. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2165 · Cited by 962 · see citing works

Estrogen and the skeleton

Khosla, S., Oursler, M. J., & Monroe, D. G. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.03.008 · Cited by 943 · see citing works

Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease

Kearns, A. E., Khosla, S., & Kostenuik, P. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0014 · Cited by 824 · see citing works

The osteoclast differentiation factor osteoprotegerin ligand is essential for mammary gland development.

Fata, J. E., Kong, Y.-Y., Li, J., Sasaki, T., Irie-Sasaki, J., Moorehead, R. A., Elliott, R., Scully, S., Voura, E. B., Lacey, D. L., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00103-3 · Cited by 756 · see citing works

The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling

Theoleyre, S., Wittrant, Y., Tat, S. K., Fortun, Y., Redini, F., & Heymann, D. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.06.004 · Cited by 663 · see citing works

Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

Naito, A., Azuma, S., Tanaka, S., Miyazaki, T., Takaki, S., Takatsu, K., Nakao, K., Nakamura, K., Katsuki, M., Yamamoto, T. S., et al. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00265.x · Cited by 626 · see citing works

The cell biology of bone metabolism

Datta, H. K., Ng, W. F., Walker, J. A., Tuck, S. P., & Varanasi, S. S. (2008) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.048868 · Cited by 614 · see citing works

Role of receptor activator of nuclear factor-κB ligand and osteoprotegerin in bone cell biology

Hofbauer, L. C., & Heufelder, A. E. (2001) · Journal of Molecular Medicine · doi:10.1007/s001090100226 · Cited by 586 · see citing works

Osteopetrosis: genetics, treatment and new insights into osteoclast function

Sobacchi, C., Schulz, A., Coxon, F. P., Villa, A., & Helfrich, M. H. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.137 · Cited by 580 · see citing works

Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women

Boivin, G., Chavassieux, P., Santora, A. C., Yates, J., & Meunier, P. J. (2000) · Bone · doi:10.1016/s8756-3282(00)00376-8 · Cited by 573 · see citing works

Mechanosensation and transduction in osteocytes

Klein-Nulend, J., Bakker, A. D., Bacabac, R. G., Vatsa, A., & Weinbaum, S. (2013) · Bone · doi:10.1016/j.bone.2012.10.013 · Cited by 528 · see citing works

B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo

Li, Y., Toraldo, G., Li, A., Yang, X., Zhang, H., Qian, W.-P., & Weitzmann, M. N. (2007) · Blood · doi:10.1182/blood-2006-07-037994 · Cited by 520 · see citing works

Osteoporosis and Inflammation

Mundy, G. R. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00353.x · Cited by 480 · see citing works

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

Neufer, P. D., Bamman, M. M., Muoio, D. M., Bouchard, C., Cooper, D. M., Goodpaster, B. H., Booth, F. W., Kohrt, W. M., Gerszten, R. E., Mattson, M. P., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.011 · Cited by 474 · see citing works

Regulation of Vascular Calcification by Osteoclast Regulatory Factors RANKL and Osteoprotegerin

Collin‐Osdoby, P. (2004) · Circulation Research · doi:10.1161/01.res.0000149165.99974.12 · Cited by 469 · see citing works

Osteoprotegerin Deficiency and Juvenile Paget's Disease

Whyte, M. P., Obrecht, S. E., Finnegan, P. M., Jones, J. L., Podgornik, M. N., McAlister, W. H., & Mumm, S. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013096 · Cited by 446 · see citing works

Glucocorticoid-Induced Osteoporosis

Buckley, L., & Humphrey, M. B. (2018) · New England Journal of Medicine · doi:10.1056/nejmcp1800214 · Cited by 438 · see citing works

Mechanical regulation of signaling pathways in bone

Thompson, W. R., Rubin, C. T., & Rubin, J. E. (2012) · Gene · doi:10.1016/j.gene.2012.04.076 · Cited by 410 · see citing works

Osteoporosis and Inflammation

Mundy, G. R. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.dec.s147-s151 · Cited by 408 · see citing works

MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL

Lynch, C. C., Hikosaka, A., Acuff, H. B., Martin, M. D., Kawai, N., Singh, R. K., Vargo-Gogola, T. C., Begtrup, J. L., Peterson, T. E., Fingleton, B., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.013 · Cited by 392 · see citing works

Denosumab: mechanism of action and clinical outcomes

Hanley, D. A., Adachi, J. D., Bell, A., & Brown, V. (2012) · International Journal of Clinical Practice · doi:10.1111/ijcp.12022 · Cited by 380 · see citing works

The RANKL/RANK/OPG pathway

Boyce, B. F., & Xing, L. (2007) · Current Osteoporosis Reports · doi:10.1007/s11914-007-0024-y · Cited by 339 · see citing works

Exercise for preventing and treating osteoporosis in postmenopausal women

Bonaiuti, D., Shea, B., Iovine, R., Négrini, S., Welch, V. A., Kemper, H. C. G., Wells, G. A., Tugwell, P., & Cranney, A. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000333 · Cited by 301 · see citing works

Effects of inflammatory and anti‐inflammatory cytokines on the bone

Schett, G. (2011) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2011.02545.x · Cited by 292 · see citing works

Effects of Resistance Exercise on Bone Health

Hong, A. R., & Kim, S. W. (2018) · Endocrinology and Metabolism · doi:10.3803/enm.2018.33.4.435 · Cited by 291 · see citing works

Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength.

KOSTENUIK, P. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.06.005 · Cited by 281 · see citing works

Osteoprotegerin Inhibits Vascular Calcification Without Affecting Atherosclerosis in <i> ldlr ^(−/−) </i> Mice

Morony, S., Tintut, Y., Zhang, Z., Cattley, R. C., Van, G., Dwyer, D., Stolina, M., Kostenuik, P. J., & Demer, L. L. (2008) · Circulation · doi:10.1161/circulationaha.107.707380 · Cited by 258 · see citing works

Exercise and bone health across the lifespan

Santos, L., Elliott-Sale, K. J., & Sale, C. (2017) · Biogerontology · doi:10.1007/s10522-017-9732-6 · Cited by 256 · see citing works

Calcium intake in bone health: a focus on calcium-rich mineral waters

Vannucci, L., Fossi, C., Quattrini, S., Guasti, L., Pampaloni, B., Gronchi, G., Giusti, F., Romagnoli, C., Cianferotti, L., Marcucci, G., et al. (2018) · Nutrients · doi:10.3390/nu10121930 · Cited by 245 · see citing works

Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-κB ligand.

Hikita, A., Yana, I., Wakeyama, H., Nakamura, M., Kadono, Y., Oshima, Y., Nakamura, K., Seiki, M., & Tanaka, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606656200 · Cited by 236 · see citing works

RhoA and Cytoskeletal Disruption Mediate Reduced Osteoblastogenesis and Enhanced Adipogenesis of Human Mesenchymal Stem Cells in Modeled Microgravity

Meyers, V. E., Zayzafoon, M., Douglas, J. T., & McDonald, J. M. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050611 · Cited by 233 · see citing works

Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation

Chen, G., Sircar, K., Aprikian, A. G., Potti, A., Goltzman, D., & Rabbani, S. A. (2006) · Cancer · doi:10.1002/cncr.21978 · Cited by 228 · see citing works

A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype

Cundy, T. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.18.2119 · Cited by 228 · see citing works

A Runx2/miR-3960/miR-2861 Regulatory Feedback Loop during Mouse Osteoblast Differentiation

Hu, R., Liu, W., Li, H., Yang, L., Chen, C., Xia, Z., Guo, L., Xie, H., Zhou, H., Wu, X., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.176099 · Cited by 226 · see citing works

Determination of Three Isoforms of the Receptor Activator of Nuclear Factor-κΒ Ligand and Their Differential Expression in Bone and Thymus*

Ikeda, T., Kasai, M., Utsuyama, M., & Hirokawa, K. (2001) · Endocrinology · doi:10.1210/endo.142.4.8070 · Cited by 215 · see citing works

Bicycle exercise enhances plasma IL-6 but does not change IL-1 alpha, IL-1 beta, IL-6, or TNF-alpha pre-mRNA in BMNC

Ullum, H., Haahr, P., Diamant, M., Palmo, J., Halkjær-Kristensen, J., & Pedersen, B. K. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.1.93 · Cited by 197 · see citing works

Exercise When Young Provides Lifelong Benefits to Bone Structure and Strength

Warden, S. J., Fuchs, R. K., Castillo, A. B., Nelson, I. R., & Turner, C. H. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061107 · Cited by 190 · see citing works

Proliferation of human-derived osteoblast-like cells depends on the cycle number and frequency of uniaxial strain

Kaspar, D., Seidl, W., Neidlinger‐Wilke, C., et al. (2002) · Journal of Biomechanics · doi:10.1016/s0021-9290(02)00058-1 · Cited by 179 · see citing works

Natural history of bone metabolism and bone mineral density in children with inflammatory bowel disease

Sylvester, F. A., Wyzga, N., Hyams, J. S., Davis, P. M., Lerer, T., Vance, K., HAWKER, G. A., & Griffiths, A. M. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20006 · Cited by 169 · see citing works

Strontium ranelate: New insights into its dual mode of action

Marie, P. J. (2007) · Bone · doi:10.1016/j.bone.2007.02.003 · Cited by 168 · see citing works

Bone and mineral disorders in chronic kidney disease: implications for cardiovascular health and ageing in the general population

Covic, A. C., Vervloet, M. G., Massy, Z. A., Ureña, P., Goldsmith, D. J. A., Brandenburg, V. M., Mazzaferro, S., Evenepoel, P., Bover, J., Apetrii, M., et al. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30310-8 · Cited by 164 · see citing works

Influence of exercise mode and osteogenic index on bone biomarker responses during short-term physical training

Lester, M., Urso, M. L., Evans, R. K., Pierce, J. R., Spiering, B. A., Maresh, C. M., Hatfield, D. L., Kraemer, W. J., & Nindl, B. C. (2009) · Bone · doi:10.1016/j.bone.2009.06.001 · Cited by 162 · see citing works

Sclerostin's role in bone's adaptive response to mechanical loading

Galea, G. L., Lanyon, L. E., & Price, J. S. (2016) · Bone · doi:10.1016/j.bone.2016.10.008 · Cited by 153 · see citing works

Effects of different magnitudes of mechanical strain on Osteoblasts in vitro

Tang, L., Lin, Z., & Li, Y. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.123 · Cited by 147 · see citing works

The roles of exercise in bone remodeling and in prevention and treatment of osteoporosis

Yuan, Y. J., Chen, X., Zhang, L., Wu, J., Guo, J., Zou, D., Chen, B., Sun, Z., Shen, C., & Zou, J. (2015) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2015.11.005 · Cited by 146 · see citing works

The role of RANK ligand/osteoprotegerin in rheumatoid arthritis

Geusens, P. (2012) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x12438080 · Cited by 144 · see citing works

Regulation of Wnt/β-catenin signaling within and from osteocytes

Burgers, T., & Williams, B. O. (2013) · Bone · doi:10.1016/j.bone.2013.02.022 · Cited by 144 · see citing works

Effects of resistance and aerobic exercise on physical function, bone mineral density, OPG and RANKL in older women

Marques, E. A., Wanderley, F. A. C., Machado, L. J., Sousa, F., Viana, J. L., Moreira‐Gonçalves, D., Moreira, P. A. M., Mota, J. A. P. S., & Carvalho, J. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.02.005 · Cited by 143 · see citing works

Aerobic exercise in the elderly: a key to successful aging.

Fleg, J. L. (2012) · PubMed · Cited by 143 · see citing works

Mechanical strain inhibits expression of osteoclast differentiation factor by murine stromal cells

Rubin, J. E., Murphy, T., Nanes, M. S., & Fan, X. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.6.c1126 · Cited by 138 · see citing works

Flavonoid Intake and Bone Health

Weaver, C. M., Alekel, D. L., Ward, W. E., et al. (2012) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2012.698220 · Cited by 137 · see citing works

The role of exercise intensity in the bone metabolic response to an acute bout of weight-bearing exercise

Scott, J. P. R., Sale, C., Greeves, J. P., Casey, A. E., Dutton, J. J., & Fraser, W. D. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00764.2010 · Cited by 136 · see citing works

The Effectiveness of Combined Exercise Interventions for Preventing Postmenopausal Bone Loss: A Systematic Review and Meta-analysis

Zhao, R., Zhang, M., & Zhang, Q. (2017) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2017.6969 · Cited by 133 · see citing works

RANKL Inhibition with Osteoprotegerin Increases Bone Strength by Improving Cortical and Trabecular bone Architecture in Ovariectomized Rats

Ominsky, M. S., Li, X., Asuncion, F., Barrero, M., Warmington, K. S., Dwyer, D., Stolina, M., Geng, Z., Grisanti, M. S., Tan, H., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080109 · Cited by 131 · see citing works

Receptor activator of NF‐κB recruits multiple TRAF family adaptors and activates c‐Jun N‐terminal kinase

Kim, H.-H., Lee, D. E., Shin, J. N., Lee, Y. S., Jeon, Y. M., Chung, C.-H., Ni, J., Kwon, B. S., & Lee, Z. H. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01731-1 · Cited by 125 · see citing works

Pamidronate treatment of bone fibrous dysplasia in nine children with McCune‐Albright syndrome

Lala, R., Matarazzo, P., Bertelloni, S., et al. (2000) · Acta Paediatrica · doi:10.1111/j.1651-2227.2000.tb01214.x · Cited by 116 · see citing works

Nutritional aspects of bone health

Rizzoli, R. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.08.003 · Cited by 115 · see citing works

Receptor Activator of NF-κB Ligand Regulates the Proliferation of Mammary Epithelial Cells via Id2

Kim, N., Kim, H.-J., Koo, B., Kwon, M.-C., Kim, Y.-W., Cho, Y., Yokota, Y., Penninger, J. M., & Kong, Y. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.3.1002-1013.2006 · Cited by 110 · see citing works

Detection of osteoprotegerin (OPG) and its ligand (RANKL) mRNA and protein in femur and tibia of the rat

Silvestrini, G., Ballanti, P., Patacchioli, F. R., Leopizzi, M., Gualtieri, N., Monnazzi, P., Tremante, E., Sardella, D., & BONUCCI, E. (2005) · The Histochemical Journal · doi:10.1007/s10735-004-3839-1 · Cited by 105 · see citing works

RANKL is downregulated in bone cells by physical activity (treadmill and vibration stimulation training) in rat with glucocorticoid-induced osteoporosis.

Pichler, K., Loreto, C., Leonardi, R. M., Reuber, T., Weinberg, A., & Musumeci, G. (2013) · PubMed · doi:10.14670/hh-28.1185 · Cited by 94 · see citing works

Does Exercise Influence Pediatric Bone? A Systematic Review

SPECKER, B. L., Thiex, N. W., & Sudhagoni, R. G. (2015) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-015-4467-7 · Cited by 93 · see citing works

Protective Effects of Estradiol on Ethanol-Induced Bone Loss Involve Inhibition of Reactive Oxygen Species Generation in Osteoblasts and Downstream Activation of the Extracellular Signal-Regulated Kinase/Signal Transducer and Activator of Transcription 3/Receptor Activator of Nuclear Factor-κB Ligand Signaling Cascade

Chen, J., Shankar, K., Nagarajan, S., Badger, T. M., & Ronis, M. J. J. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.130351 · Cited by 91 · see citing works

Peripubertal female athletes in high-impact sports show improved bone mass acquisition and bone geometry

Maı̈moun, L., Coste, O., Philibert, P., Briot, K., Mura, T., Galtier, F., Mariano‐Goulart, D., Paris, F., & Sultan, C. (2013) · Metabolism · doi:10.1016/j.metabol.2012.11.010 · Cited by 87 · see citing works

Barriers to Effective Postmenopausal Osteoporosis Treatment: A Qualitative Study of Patients’ and Practitioners’ Views

Alami, S., Hervouet, L., Poiraudeau, S., Briot, K., & Roux, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158365 · Cited by 87 · see citing works

The Role of Diet in Osteoporosis Prevention and Management

Levis, S., & Lagari, V. S. (2012) · Current Osteoporosis Reports · doi:10.1007/s11914-012-0119-y · Cited by 82 · see citing works

Response of Bone Turnover Markers and Cytokines to High-Intensity Low-Impact Exercise

Mezil, Y., ALLISON, D., Kish, K., Ditor, D. S., Ward, W. E., Tsiani, E., & Klentrou, P. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000555 · Cited by 80 · see citing works

Response of bone mineral density, inflammatory cytokines, and biochemical bone markers to a 32-week combined loading exercise programme in older men and women.

Marques, E., Mota, J., Viana, J., Tuna, D., Figueiredo, P., Guimarães, J., & Carvalho, J. (2013) · Archives of gerontology and geriatrics (Print) · doi:10.1016/j.archger.2013.03.014 · Cited by 78 · see citing works

A selective EP4 receptor antagonist abrogates the stimulation of osteoblast recruitment from bone marrow stromal cells by prostaglandin E2 in vivo and in vitro

Shamir, D., Keila, S., & Weinreb, M. (2003) · Bone · doi:10.1016/j.bone.2003.09.008 · Cited by 68 · see citing works

Effects of plyometric exercise session on markers of bone turnover in boys and young men

Kish, K., Mezil, Y., Ward, W. E., Klentrou, P., & Falk, B. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3191-z · Cited by 65 · see citing works

Mechanical stress directly suppresses osteoclast differentiation in RAW264.7 cells

Suzuki, N., Yoshimura, Y., Deyama, Y., Suzuki, K., & Kitagawa, Y. (2008) · International Journal of Molecular Medicine · doi:10.3892/ijmm.21.3.291 · Cited by 64 · see citing works

Pharmacological management of osteogenesis

Nardone, V., D’Asta, F., & Brandi, M. L. (2014) · Clinics · doi:10.6061/clinics/2014(06)12 · Cited by 62 · see citing works

RANK pathway in giant cell tumor of bone: pathogenesis and therapeutic aspects

Wu, P., Tang, J., & Li, K. (2015) · Tumor Biology · doi:10.1007/s13277-015-3094-y · Cited by 59 · see citing works

Physical training increases osteoprotegerin in postmenopausal women

Bergström, I. B., Parini, P., Gustafsson, S. A., Andersson, G., & Brinck, J. W. (2011) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-011-0304-6 · Cited by 58 · see citing works

Mechanical stimulation effects on functional end effectors in osteoblastic MG-63 cells

Saunders, M. M., Taylor, A. F., Du, C., et al. (2005) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2005.04.011 · Cited by 55 · see citing works

Dose‐response effects of exercise on bone mineral density and content in post‐menopausal women

Encabo, P. G., McNeil, J., Boyne, D. J., Courneya, K. S., & Friedenreich, C. M. (2019) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.13443 · Cited by 54 · see citing works

Regulation of bone remodeling and emerging breakthrough drugs for osteoporosis and osteolytic bone metastases

Boyce, B. F., Xing, L., Shakespeare, W. C., Wang, Y., Dalgarno, D. C., Iuliucci, J. D., & Sawyer, T. K. (2003) · Kidney International · doi:10.1046/j.1523-1755.63.s85.2.x · Cited by 53 · see citing works

Diet and Exercise: a Match Made in Bone

Willems, H. M. E., van den Heuvel, E. G. H. M., Schoemaker, R., Klein‐Nulend, J., & Bakker, A. D. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0406-8 · Cited by 53 · see citing works

Exercise in youth: high bone mass, large bone size, and low fracture risk in old age

Tveit, M., Rosengren, B. E., Nilsson, J. Å., & Karlsson, M. K. (2015) · Scandinavian Journal of Medicine &amp; Science in Sports · doi:10.1111/sms.12305 · Cited by 49 · see citing works

Increased Plasma Osteoprotegerin Concentrations Are Associated with Indices of Bone Strength of the Hip

Samelson, E. J., Broe, K. E., Demissie, S., Beck, T., Karasik, D., Kathiresan, S., & Kiel, D. P. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2492 · Cited by 47 · see citing works

The mechanisms underlying the beneficial effects of exercise on bone remodeling: Roles of bone-derived cytokines and microRNAs

Qi, Z., Liu, W., & Lu, J. (2016) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2016.05.010 · Cited by 47 · see citing works

The effects of exercise on bone. Basic concepts and implications for the prevention of fractures.

Russo, C. R. (2009) · PubMed Central · Cited by 46 · see citing works

Chocolate and chocolate constituents influence bone health and osteoporosis risk

Seem, S. A., Yuan, Y., & Tou, J. C. L. (2019) · Nutrition · doi:10.1016/j.nut.2019.02.011 · Cited by 45 · see citing works

Movement-Based Behaviors and Leukocyte Telomere Length among US Adults

Loprinzi, P. D., Loenneke, J. P., & Blackburn, E. H. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000695 · Cited by 41 · see citing works

Proinflammatory cytokines and receptor activator of nuclear factor κB-ligand/osteoprotegerin associated with bone deterioration in patients with Crohnʼs disease

Turk, N., Čuković‐Čavka, S., Koršić, M., Turk, Z., & Vucelic, B. N. (2009) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3283200032 · Cited by 41 · see citing works

Impact of acute exercise on bone turnover and growth hormone/insulin-like growth factor axis in boys.

Pomerants, T., Tillmann, V., Karelson, K., et al. (2008) · PubMed · Cited by 37 · see citing works

Dose-Dependent Effects of Triiodothyronine on the Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells

Boeloni, J. N., Ocarino, N. M., de Melo, A. B. S., Silva, J. F., Castanheira, P., Goes, A. M., & Serákides, R. (2009) · Hormone Research in Paediatrics · doi:10.1159/000232161 · Cited by 35 · see citing works

In peripubertal girls, artistic gymnastics improves areal bone mineral density and femoral bone geometry without affecting serum OPG/RANKL levels

Maı̈moun, L., Coste, O., Mariano‐Goulart, D., et al. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1541-1 · Cited by 35 · see citing works

Endurance running acutely raises plasma osteoprotegerin and lowers plasma receptor activator of nuclear factor κ B ligand

Ziegler, S., Niessner, A., Richter, B., et al. (2005) · Metabolism · doi:10.1016/j.metabol.2005.02.009 · Cited by 34 · see citing works

Effectiveness of Exercise for Managing Osteoporosis in Women Postmenopause

Palombaro, K. M., Black, J. D., Buchbinder, R., & Jette, D. U. (2013) · Physical Therapy · doi:10.2522/ptj.20110476 · Cited by 34 · see citing works

Pamidronate treatment of bone fibrous dysplasia in nine children with McCune-Albright syndrome

Lala, R., Matarazzo, P., Bertelloni, S., et al. (2000) · Acta Paediatrica · doi:10.1080/080352500750028816 · Cited by 33 · see citing works

Anabolic effects of PTH and the ‘anabolic window’

Pazianas, M. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.01.004 · Cited by 31 · see citing works

Wnt Signaling–Related Osteokines and Transforming Growth Factors Before and After a Single Bout of Plyometric Exercise in Child and Adolescent Females

Dekker, J., Nelson, K., Kurgan, N., et al. (2017) · Pediatric Exercise Science · doi:10.1123/pes.2017-0042 · Cited by 31 · see citing works

Endurance exercise and growth hormone improve bone formation in young and growth-retarded chronic kidney disease rats

Troib, A., Guterman, M., Rabkin, R., Landau, D., & Segev, Y. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv373 · Cited by 29 · see citing works

Effects of low-repetition jump exercise on osteogenic response in rats

Nagasawa, S., Honda, A., Sogo, N., et al. (2008) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-007-0812-6 · Cited by 26 · see citing works

The association of bone metabolism with bone mineral density, serum sex hormone concentrations, and regular exercise in middle-aged men

Remes‐Pakarinen, T., Väisänen, S., Mahonen, A., Huuskonen, J., Kröger, H., Jurvelin, J. S., Penttila, I. M., & Rauramaa, R. (2004) · Bone · doi:10.1016/j.bone.2004.04.020 · Cited by 25 · see citing works

Systematic review: associations of calcium intake, vitamin D intake, and physical activity with skeletal outcomes in people with Type 1 diabetes mellitus

Gil-Díaz, M. C., Raynor, J., O'Brien, K. O., Schwartz, G. J., & Weber, D. R. (2019) · Acta Diabetologica · doi:10.1007/s00592-019-01334-5 · Cited by 22 · see citing works

Genetics of aging bone

Adams, D. J., Rowe, D. W., & Ackert‐Bicknell, C. L. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9650-y · Cited by 20 · see citing works

Insulinogenic sucrose + amino acid mixture ingestion immediately after resistance exercise has an anabolic effect on bone compared with non-insulinogenic fructose + amino acid mixture in growing rats

Notomi, T., Karasaki, I., Okazaki, Y., Okimoto, N., Kato, Y., Ohura, K., Noda, M., Nakamura, T., & Suzuki, M. (2014) · Bone · doi:10.1016/j.bone.2014.05.002 · Cited by 18 · see citing works

A comparative study of mechanical strain, icariin and combination stimulations on improving osteoinductive potential via NF-kappaB activation in osteoblast-like cells

Wang, Q., Zhang, X.-C., Zhang, X.-C., et al. (2015) · BioMedical Engineering OnLine · doi:10.1186/s12938-015-0039-z · Cited by 16 · see citing works

Wnt Signaling–Related Osteokines at Rest and Following Plyometric Exercise in Prepubertal and Early Pubertal Boys and Girls

Klentrou, P., Angrish, K., Awadia, N., Kurgan, N., Kouvelioti, R., & Falk, B. (2018) · Pediatric Exercise Science · doi:10.1123/pes.2017-0259 · Cited by 13 · see citing works

Effects of 12-week combined exercise on RANKL/RANK/OPG signaling and bone-resorption cytokines in healthy college females

Kim, J., Kim, H., & Kim, C. (2019) · Physical Activity and Nutrition · doi:10.20463/jenb.2019.0003 · Cited by 13 · see citing works

Prevalent and Emerging Therapies for Osteoporosis

Brar, K. (2010) · Medical Journal Armed Forces India · doi:10.1016/s0377-1237(10)80050-4 · Cited by 9 · see citing works

Do walking programs affect C-reactive protein, osteoprotegerin and soluble receptor activator of nuclear factor-kappaβ ligand?

Esen, H., Büyükyazı, G., Ulman, C., et al. (2009) · Turkish Journal of Biochemistry · Cited by 5 · see citing works

The Effects of Exercise Intensity Difference on Bone Metabolic Markers and Cytokines of the RANKL/RANK/OPG System in Korean Osteopenia Elderly Women

Kim, C.-S., Kim, H., Kim, J.-Y., Kim, J., Park, D., Lim, S.-T., & Min, S. (2017) · Exercise Science · doi:10.15857/ksep.2017.26.1.87 · Cited by 4 · see citing works

The Effects of Acute Exercise on RANKL/RANK/OPG Pathway and Bone Metabolic Markers in Healthy College Female

Kim, J., Kim, H., Park, D., Shin, Y., Min, S.-K., & Kim, C.-S. (2018) · Exercise Science · doi:10.15857/ksep.2018.27.3.225 · Cited by 3 · see citing works

An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis

Weng, W., Li, H., & Zhu, S. (2022) · Genes · doi:10.3390/genes13050806 · Cited by 65 · see citing works

Local and Systemic Peptide Therapies for Soft Tissue Regeneration: A Narrative Review

Cushman, C. J., Ibrahim, A. F., Smith, A. D., Hernandez, E. J., MacKay, B., & Zumwalt, M. (2024) · The Yale Journal of Biology and Medicine · doi:10.59249/tknm3388 · Cited by 12 · see citing works

[Expressions of RANK, RANKL, and osteoprotegerin in male rats at different ages].

Zhou, X., Liu, Y., Jian, X.-C., et al. (2011) · PubMed · Cited by 1 · see citing works

[Indication of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) in gingival crevicular fluid to remodeling of alveolar bone during retention].

Zhao, N., Lin, J., Chen, Z., et al. (2012) · PubMed · Cited by 1 · see citing works

Different expressing levels of osteoprotegerin and receptor activator of nuclear factor-κB ligand from osteoblasts of young, adult and aged mice

Jian-zhon, H. (2005) · Zhonghua fengshibingxue zazhi

Aging effect of osteoprotegerin and receptor activator of nuclear factor-κB ligand expression in human periodontal ligament cells under continuous static pressure.

Wu, J., Cui, Z., Yu, H., et al. (2022) · PubMed · doi:10.7518/hxkq.2022.06.005 · Cited by 3 · see citing works

EFFECTS OF 1α,25(OH)_2D_3 ON THE EXPRESSION OF RECEPTOR ACTIVATOR OF NF-КB LIGAND AND OSTEOPROTEGERIN IN RAT OSTEOBLASTS IN VITRO

Zong-ping, L. (2010) · Acta Nutrimenta Sinica