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Cited by 1,535

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Bone's mechanostat: A 2003 update

Frost, Harold M.·2003·The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology
DOI 10.1002/ar.a.10119
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Abstract

The still‐evolving mechanostat hypothesis for bones inserts tissue‐level realities into the former knowledge gap between bone's organ‐level and cell‐level realities. It concerns load‐bearing bones in postnatal free‐living bony vertebrates, physiologic bone loading, and how bones adapt their strength to the mechanical loads on them. Voluntary mechanical usage determines most of the postnatal strength of healthy bones in ways that minimize nontraumatic fractures and create a bone‐strength safety factor. The mechanostat hypothesis predicts 32 things that occur, including the gross anatomical bone abnormalities in osteogenesis imperfecta; it distinguishes postnatal situations from baseline conditions at birth; it distinguishes bones that carry typical voluntary loads from bones that have other chief functions; and it distinguishes traumatic from nontraumatic fractures. It provides functional definitions of mechanical bone competence, bone quality, osteopenias, and osteoporoses. It includes permissive hormonal and other effects on bones, a marrow mediator mechanism, some limitations of clinical densitometry, a cause of bone “mass” plateaus during treatment, an “adaptational lag” in some children, and some vibration effects on bones. The mechanostat hypothesis may have analogs in nonosseous skeletal organs as well. Anat Rec Part A 275A:1081–1101, 2003. © 2003 Wiley‐Liss, Inc.

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Metadata

Authors
Frost, H. M.
Venue
The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology
Publisher
Wiley
Published
2003-11-03
Volume
275A
Issue
2
Pages
1081-1101
ISSN
  • 1552-4884 (ISSN-L)
  • 1552-4892
DOI
10.1002/ar.a.10119
OpenAlex
W2024916097
Cited by
1,535
References
8
FWCI
13.66
Type
journal article
Language
en
Open access
closed

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