Anatomical analysis of an aye‐aye brain ( Daubentonia madagascariensis , primates: Prosimii) combining histology, structural magnetic resonance imaging, and diffusion‐tensor imaging
Open accessAbstract
This report presents initial results of a multimodal analysis of tissue volume and microstructure in the brain of an aye‐aye ( Daubentonia madagascariensis ). The left hemisphere of an aye‐aye brain was scanned using T2‐weighted structural magnetic resonance imaging (MRI) and diffusion‐tensor imaging (DTI) prior to histological processing and staining for Nissl substance and myelinated fibers. The objectives of the experiment were to estimate the volume of gross brain regions for comparison with published data on other prosimians and to validate DTI data on fiber anisotropy with histological measurements of fiber spread. Measurements of brain structure volumes in the specimen are consistent with those reported in the literature: the aye‐aye has a very large brain for its body size, a reduced volume of visual structures (V1 and LGN), and an increased volume of the olfactory lobe. This trade‐off between visual and olfactory reliance is likely a reflection of the nocturnal extractive foraging behavior practiced by Daubentonia . Additionally, frontal cortex volume is large in the aye‐aye, a feature that may also be related to its complex foraging behavior and sensorimotor demands. Analysis of DTI data in the anterior cingulum bundle demonstrates a strong correlation between fiber spread as measured from histological sections and fiber spread as measured from DTI. These results represent the first quantitative comparison of DTI data and fiber‐stained histology in the brain. © 2005 Wiley‐Liss, Inc.
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Classical DTI postmortem histological validation studies have shown that fiber orientation is correctly represented in large unidirectional fiber bundles, but fails in complex regions with fiber crossings and low anisotropy.
“Classical DTI postmortem histological validation studies have shown that fiber orientation is correctly represented in large unidirectional fiber bundles, but fails in complex regions with fiber crossings and low anisotropy (44–46).”
From Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates (2022) · cites this paper as [45]
The Diffusion-Tensor Imaging section (page unavailable) reports good correspondence between DTI and histological measurements in the cingulum bundle, supporting the claim for coherent fibers. It also finds broader fiber-orientation distributions where anisotropy is low, but does not show that DTI fails there or test regions with crossing fibers. (LLM, conf=0.88)
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- Authors
- Kaufman, J. A., Ahrens, E. T., Laidlaw, D. H., Zhang, S., & Allman, J. M.
- Affiliations
- California Institute of Technology (US)
- Carnegie Mellon University (US)
- Brown University (US)
- Corresponding author
- Allman, John M.
- Venue
- The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology
- Publisher
- Wiley
- Published
- 2005-10-07
- Volume
- 287A
- Issue
- 1
- Pages
- 1026-1037
- ISSN
- 1552-4884 (ISSN-L)
- 1552-4892
- OpenAlex
- W2103751374
- Cited by
- 54
- References
- 31
- Citations by year
- 2025: 3 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 8
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Science Foundation (0086065)
- David and Lucile Packard Foundation
- Gordon and Betty Moore Foundation
- National Institutes of Health
- National Institute of Environmental Health Sciences (P50-ES049617)
- National Institute of Biomedical Imaging and Bioengineering (P41EB001977, R01EB003453)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Health Sciences › Medicine › Urology › Comparative Animal Anatomy Studies
- Keywords
- aye-aye, Daubentonia madagascariensis, brain volume, visual cortex, olfactory lobe, frontal cortex, fiber anisotropy, brain microstructure
- MeSH terms
- Animals, Brain, Strepsirhini, Visual Pathways, Anisotropy, Diffusion Magnetic Resonance Imaging, Body Size
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