The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjögren's syndrome
Abstract
Objective: To delineate the mechanism of the abnormalities in B cell biology found in patients with primary Sjögren's syndrome (SS). Methods: The distribution of peripheral B cell subpopulations in 21 patients with primary SS was analyzed by immunofluorescence labeling and flow cytometry. Immunoglobulin rearrangements were analyzed in single B cells isolated from the peripheral blood and parotid glands by fluorescence‐activated cell sorting. Results: A significant reduction in the number of peripheral CD27+ memory B cells was found in SS patients, including a significantly reduced number of CD27+/IgD+/IgM+/CD5+ memory B cells. Remarkably, SS patients with secondary lymphoma uniquely exhibited an increase in CD27‐expressing peripheral B cells, including CD27 high plasmablasts. Molecular analysis for mutated Ig gene rearrangements confirmed that CD27 expression distinguished naive and memory cells in SS. In contrast to the peripheral blood, the majority of parotid B cells from 1 patient examined exhibited both the mutational status and phenotype of memory B cells. Accordingly, the mutational frequencies of V H rearrangements were significantly greater in parotid B cells than in peripheral blood B cells, whereas the V H gene repertoire appeared to be very similar between the compartments. Conclusion: These data indicate that there is an accumulation/retention of memory B cells in the inflamed salivary glands of SS patients. It is possible that preferential accumulation of CD27+ memory B cells in the inflamed parotid gland explains their reduction in the peripheral blood.
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Self-citationB1 cells: similarities and differences with other B cell subsets
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The Risk of Lymphoma Development in Autoimmune Diseases: A Meta-analysis
Zintzaras, E. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.20.2337 · Cited by 771
The Role of Innate and Adaptive Immunity in Parkinson's Disease
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Jacobi, A. M., Reiter, K., Mackay, M., Aranow, C., Hiepe, F., Radbruch, A., Hansen, A., Burmester, G., Diamond, B., Lipsky, P. E., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23498 · Cited by 289
Self-citationPathogenetic mechanisms in the initiation and perpetuation of Sjögren's syndrome
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Metadata
- Authors
- Hansen, A., Odendahl, M., Reiter, K., Jacobi, A. M., Feist, E., Scholze, J., Burmester, G. R., Lipsky, P. E., & Dörner, T.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2002-08
- Volume
- 46
- Issue
- 8
- Pages
- 2160-2171
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2004351167
- Cited by
- 271
- References
- 36
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- closed
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