The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Comparison of human stem cells derived from various mesenchymal tissues: Superiority of synovium as a cell source
Abstract
Objective: To compare the properties of human mesenchymal stem cells (MSCs) isolated from bone marrow, synovium, periosteum, skeletal muscle, and adipose tissue. Methods: Human mesenchymal tissues were obtained from 8 donors during knee surgery for ligament injury. After collagenase digestion or gradient‐density separation, nucleated cells were plated at an appropriate density for expansion at the maximum rate without colony‐to‐colony contact. Yield, expandability, differentiation potential, and epitope profile were compared among MSCs from the 5 different tissue sources. Results: Colony number per 10 3 nucleated cells was lower, and cell number per colony was higher, in bone marrow than in other mesenchymal tissues. When the cells were replated at low density every 14 days, bone marrow–, synovium‐, and periosteum‐derived cells retained their proliferation ability even at passage 10. In chondrogenesis studies in which the cells were pelleted and cultured in vitro, pellets from bone marrow–, synovium‐, and periosteum‐derived cells were shown to be larger and stained more extensively for cartilage matrix. Synovium‐derived cells, in particular, had the greatest ability for chondrogenesis. In adipogenesis experiments, the frequency of oil red O–positive colonies was highest in synovium‐ and adipose tissue–derived cells. In studies of osteogenesis, the rate of alizarin red–positive colonies was highest in bone marrow–, synovium‐, and periosteum‐derived cells. For epitope profiling, 15 surface antigens were measured. Most appeared to have similar epitope profiles irrespective of cell source. Conclusion: Our findings indicate that there are significant differences in MSC properties according to tissue source, beyond donor and experimental variation. Superiority of synovium as a potential source of MSCs for clinical applications was demonstrated.
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Cites
Comparison of Multi-Lineage Cells from Human Adipose Tissue and Bone Marrow
De Ugarte, D. A., Morizono, K., Elbarbary, A., Alfonso, Z., Zuk, P. A., Zhu, M., Dragoo, J. L., Ashjian, P., Thomas, B., Benhaim, P., et al. (2003) · Cells Tissues Organs · doi:10.1159/000071150 · Cited by 1,173
Sekiya, I., Vuoristo, J. T., Larson, B. L., & Prockop, D. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052716199 · Cited by 648
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In Search of the In Vivo Identity of Mesenchymal Stem Cells
da Silva Meirelles, L., Caplan, A. I., & Nardi, N. B. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1122 · Cited by 1,077
Chung, C., & Burdick, J. A. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.027 · Cited by 760
Tissue Engineering and Cell-Based Therapies for Fractures and Bone Defects
Perez, J. R., Kouroupis, D., Li, D. J., Best, T. M., Kaplan, L., & Correa, D. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00105 · Cited by 390
Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis
Koh, Y.-G., & Choi, Y.-J. (2012) · The Knee · doi:10.1016/j.knee.2012.04.001 · Cited by 392
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The Origins of Mesenchymal Stromal Cell Heterogeneity
Pevsner-Fischer, M., Levin, S., & Zipori, D. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-011-9229-7 · Cited by 251
3D bioprinting of BM-MSCs-loaded ECM biomimetic hydrogels for in vitro neocartilage formation
Costantini, M., Idaszek, J., Szöke, K., Jaroszewicz, J., Dentini, M., Barbetta, A., Brinchmann, J. E., & Święszkowski, W. (2016) · Biofabrication · doi:10.1088/1758-5090/8/3/035002 · Cited by 250
Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis
Elabd, C., Basillais, A., Beaupied, H., Breuil, V., Wagner, N., Scheideler, M., Zaragosi, L.-E., Massiéra, F., Lemichez, E., Trajanoski, Z., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0127 · Cited by 202
Potential implications of mesenchymal stem cells in cancer therapy
Dai, L.-J., Moniri, M. R., Zeng, Z.-R., Zhou, J. X., Rayat, J., & Warnock, G. L. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.02.012 · Cited by 99
Hao, Z., Wang, S., Zhang, X., & Lu, J. (2016) · Cell Proliferation · doi:10.1111/cpr.12242 · Cited by 88
Effects of Severe Hypoxia on Bone Marrow Mesenchymal Stem Cells Differentiation Potential
Cicione, C., Muiños-López, E., Hermida-Gómez, T., Fuentes-Boquete, I., Díaz-Prado, S., & Blanco, F. J. (2013) · Stem Cells International · doi:10.1155/2013/232896 · Cited by 84
Derakhshankhah, H., Sajadimajd, S., Jafari, S., Izadi, Z., Sarvari, S., Sharifi, M., Falahati, M., Moakedi, F., Muganda, W. C. A., Müller, M., et al. (2020) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2020.102149 · Cited by 48
Metadata
- Authors
- Sakaguchi, Y., Sekiya, I., Yagishita, K., & Muneta, T.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2005-07-28
- Volume
- 52
- Issue
- 8
- Pages
- 2521-2529
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W1995122819
- Cited by
- 1,521
- References
- 2
- FWCI
- 21.98
- Type
- journal article
- Language
- en
- Open access
- closed
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