Association between depression and anxiety in high-functioning children with autism spectrum disorders and maternal mood symptoms
Open accessAbstract
Research suggests that children with autism spectrum disorders (ASDs) and their relatives have high rates of depression and anxiety. However, relatively few studies have looked at both factors concurrently. This study examined the potential relationship between maternal mood symptoms and depression and anxiety in their children with ASD. Participants were 31 10‐ to 17‐year‐old children with an ASD diagnosis that was supported by gold‐standard measures and their biological mothers. Mothers completed the Autism Comorbidity Interview to determine whether the child with ASD met criteria for any depressive or anxiety diagnoses and a questionnaire of their own current mood symptoms. As expected, many children with ASD met criteria for lifetime diagnoses of depressive (32%) and anxiety disorders (39%). Mothers' report of their own current mood symptoms revealed averages within the normal range, though there was significant variability. Approximately 75% of children with ASD could be correctly classified as having a depressive or anxiety disorder history or not based on maternal symptoms of interpersonal sensitivity, hostility, phobic anxiety, depression, and anxiety. The results provide preliminary evidence that maternal mood symptoms may be related to depression and anxiety in their children with ASD. Although the design did not allow for testing of heritability per se, the familial transmission patterns were generally consistent with research in typical populations. While larger follow‐up studies are needed, this research has implications for prevention and intervention efforts.
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High rates of mood and anxiety disorders in first-degree family members of children with autism spectrum disorder and conceptualization of such problems as part of the broader autism phenotype raise the possibility of an underlying genetic predisposition to emotion regulation problems in autism spectrum disorder.
“Finally, high rates of mood and anxiety disorders in the first degree family members of children with ASD,32,33 and conceptualization of such problems as part of the broader autism phenotype,34 raise the possibility of an underlying genetic predisposition to ER problems in ASD as well.”
From Emotion Regulation (2014) · cites this paper as [33]
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Self-citation
- Authors
- Mazefsky, C. A., Conner, C. M., & Oswald, D. P.
- Affiliations
- University of Pittsburgh (US)
- Virginia Commonwealth University (US)
- Corresponding author
- Mazefsky, Carla A.
- Venue
- Autism Research
- Publisher
- Wiley
- Published
- 2010-06
- Volume
- 3
- Issue
- 3
- Pages
- 120-127
- ISSN
- 1939-3792 (ISSN-L)
- 1939-3806
- PMC
- PMC3374580
- OpenAlex
- W2095146431
- Cited by
- 70
- References
- 34
- Citations by year
- 2023: 3 · 2022: 1 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 6 · 2014: 12 · 2013: 6 · 2012: 10
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Autism Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD060601)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
- Keywords
- autism spectrum disorder, depression, anxiety disorders, high-functioning children, family transmission, comorbidities, maternal depression, maternal anxiety, phobic anxiety, interpersonal sensitivity, hostility
- MeSH terms
- Adolescent, Anxiety Disorders, Child, Cross-Sectional Studies, Depressive Disorder, Female, Humans, Infant, Intelligence, Male, Mothers, Personality Inventory, Psychometrics, Risk Factors, Child of Impaired Parents, Mood Disorders, Genetic Predisposition to Disease
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