Cited by 94Maternal and Neonatal HealthcareNeonatal and Maternal InfectionsPregnancy and Medication Impact

Prevalence of self-reported infection during pregnancy among control mothers in the National Birth Defects Prevention Study

Collier, Sarah A., Rasmussen, Sonja A., Feldkamp, Marcia L., Honein, Margaret A.·2009·Birth Defects Research Part A: Clinical and Molecular Teratology

Abstract

BACKGROUND: Although specific maternal infections during pregnancy have been associated with birth defects and other adverse pregnancy outcomes, the prevalence of infections during pregnancy has not been well described. METHODS: We estimated the prevalence of self‐reported infection among 4967 women with live‐born infants without major birth defects. We assessed the prevalence of reported infections and fever by type of infection, specific illness, and maternal characteristics including race and age. RESULTS: Overall, 63.6% of women reported at least one infection during pregnancy. Reports of infections were more common during pregnancy than in the 3 months before pregnancy. Nearly half (49.6%) of women reported a respiratory infection, 20.5% reported a fever, 17.1% reported a urinary tract infection, 4.2% reported a yeast infection, and 3.4% reported a sexually transmitted disease. A subanalysis of self‐reported infection and preterm delivery was performed among primiparous mothers with singleton pregnancies, but no statistically significant differences in infection prevalence were found. Women younger than 35 years reported nonrespiratory infections more frequently than women aged 35 years or older (prevalence ratio [PR] 1.41; 95% confidence interval [CI]: 1.21–1.64). Prevalence of nonrespiratory infections was also higher among those who smoked than among those who did not (PR 1.33; 95% CI: 1.20–1.47). CONCLUSIONS: Reported infections during pregnancy are common, implying that a small increase in risk for birth defects or other adverse pregnancy outcomes could have a significant public health effect and underscoring the importance of understanding the effects of prenatal infections. Birth Defects Research (PartA) 2009. © 2008 Wiley‐Liss, Inc.

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Crossref · 10.1002/bdra.20540

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Authors
Collier, S. A., Rasmussen, S. A., Feldkamp, M. L., & Honein, M. A.
Affiliations
  • Centers for Disease Control and Prevention (US)
  • University of Utah (US)
Corresponding author
Collier, Sarah A.
Venue
Birth Defects Research Part A: Clinical and Molecular Teratology
Publisher
Wiley
Published
2008-12-11
Volume
85
Issue
3
Pages
193-201
ISSN
  • 1542-0752 (ISSN-L)
  • 1542-0760
OpenAlex
W2071732363
Cited by
94
References
66
Citations by year
2025: 5 · 2024: 8 · 2023: 13 · 2022: 12 · 2021: 9 · 2020: 7 · 2019: 6 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 4 · 2013: 2 · 2012: 2
FWCI
5.14
Type
journal article
Language
en
Open access
closed
Locations
  • Birth Defects Research Part A Clinical and Molecular Teratology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Energy
  • Centers for Disease Control and Prevention
  • Oak Ridge Institute for Science and Education
Topics
  • Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords
infection prevalence, respiratory infections, fever, urinary tract infection, yeast infections, sexually transmitted infections, preterm birth, maternal smoking, maternal age, birth defects prevention, National Birth Defects Prevention Study
MeSH terms
Congenital Abnormalities, Adult, Data Collection, Female, Humans, Pregnancy, Pregnancy Complications, Infectious, Respiratory Tract Infections, Sexually Transmitted Diseases, Urinary Tract Infections, Prevalence, Premature Birth

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