Maternal prenatal infection and anxiety predict neurodevelopmental outcomes in middle childhood
Open accessAbstract
= 7,042). Child neurodevelopment at approximately 8 years of age was assessed by in-person testing, reports of social and communication problems associated with autism, and psychiatric evaluation. Covariates included psychosocial, demographic, and perinatal/obstetric risks. Prenatal infection was associated with increased likelihood of co-occurring prenatal risk, including anxiety. Regression analyses indicated that both prenatal infection and prenatal anxiety predicted child social and communication problems; the predictions were largely independent of each other. Comparable effects were also found for the prediction of symptoms of attention problems and anxiety symptoms. These results provide the first evidence for the independent effects of prenatal infection and anxiety on a broad set of neurodevelopmental and behavioral and emotional symptoms in children, suggesting the involvement of multiple mechanisms in the prenatal programming of child neurodevelopment. The results further underscore the importance of promoting prenatal physical and mental health for child health outcomes. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is extensive evidence in humans showing that prenatal infectious exposure is associated with cognitive and other neurodevelopmental impairments.
“Furthermore, there is extensive evidence in humans showing that prenatal infectious exposure is associated with cognitive and other neurodevelopmental impairments (463, 464).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [464]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Detection of Postnatal Depression: Development of the 10-item Edinburgh Postnatal Depression Scale
Cox, J. L., Holden, J. M., & Sagovsky, R. (1987) · British Journal of Psychiatry · doi:10.1192/bjp.150.6.782 · Cited by 13,982 · see citing works
Boyd, A., Golding, J., Macleod, J., Lawlor, D. A., Fraser, A., Henderson, J., Molloy, L., Ness, A., Ring, S., & Davey Smith, G. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dys064 · Cited by 2,996 · see citing works
Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort
Fraser, A., Macdonald-Wallis, C., Tilling, K., Boyd, A., Golding, J., Davey Smith, G., Henderson, J., Macleod, J., Molloy, L., Ness, A., et al. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dys066 · Cited by 2,494 · see citing works
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426 · see citing works
Schizophrenia risk from complex variation of complement component 4
Sekar, A., Bialas, A. R., de Rivera, H., Davis, A., Hammond, T. R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V., et al. (2016) · Nature · doi:10.1038/nature16549 · Cited by 2,394 · see citing works
Goodman, R., Ford, T., Richards, H., Gatward, R., & Meltzer, H. (2000) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2000.tb02345.x · Cited by 1,755 · see citing works
A systematic review and meta-regression of the prevalence and incidence of perinatal depression
Woody, C. A., Ferrari, A. J., Siskind, D. J., Whiteford, H. A., & Harris, M. G. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.05.003 · Cited by 1,577 · see citing works
Preventive strategies for mental health
Arango, C., Díaz-Caneja, C. M., McGorry, P. D., Rapoport, J., Sommer, I. E., Vorstman, J. A., McDaid, D., Marín, O., Serrano-Drozdowskyj, E., Freedman, R., et al. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30057-9 · Cited by 1,271 · see citing works
The British Child and Adolescent Mental Health Survey 1999: The Prevalence of DSM-IV Disorders
FORD, T., GOODMAN, R., & MELTZER, H. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200310000-00011 · Cited by 1,227 · cited 1× · see citing works
“Symptoms of ADHD, anxiety, depression, and disruptive behavior were derived from the Development and Well-Being Assessment (DAWBA; Goodman et al., 2000), a validated psychiatric assessment tool widely used in epidemiological studies (Ford et al., 2003).”
Maternal immune activation: Implications for neuropsychiatric disorders
Estes, M. L., & McAllister, A. K. (2016) · Science · doi:10.1126/science.aag3194 · Cited by 1,206 · cited 2× · see citing works
“A prevailing model was that pregnancy was an immunosuppressive state and that a successful pregnancy was dependent on a shift to a Th2/anti-in fl ammatory response, although research has considered a wide array of pro-and anti-in fl ammatory cytokines such as interleukin(IL)-6, IL-17 or TNF-alpha (Estes & McAllister, 20…”
Van den Bergh, B. R. H., van den Heuvel, M. I., Lahti, M., Braeken, M., de Rooij, S. R., Entringer, S., Hoyer, D., Roseboom, T., Räikkönen, K., King, S., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.003 · Cited by 1,181 · see citing works
Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years
O'Connor, T. G., Heron, J., Golding, J., Beveridge, M., & Glover, V. (2002) · British Journal of Psychiatry · doi:10.1192/bjp.180.6.502 · Cited by 1,070 · see citing works
Self-citationSerologic Evidence of Prenatal Influenza in the Etiology of Schizophrenia
Brown, A. S., Begg, M. D., Gravenstein, S., Schaefer, C. A., Wyatt, R. J., Bresnahan, M. A., Babulas, V. P., & Susser, E. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.774 · Cited by 1,048 · see citing works
Self-citationEarly Life Programming and Neurodevelopmental Disorders
Bale, T. L., Baram, T. Z., Brown, A. S., Goldstein, J. M., Insel, T. R., McCarthy, M. M., Nemeroff, C. B., Reyes, T. M., Simerly, R. B., Susser, E. S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.028 · Cited by 961 · see citing works
Self-citationMaternal Infection and Cerebral Palsy in Infants of Normal Birth Weight
Grether, J. K. (1997) · JAMA · doi:10.1001/jama.1997.03550030047032 · Cited by 821 · see citing works
Malkova, N. V., Yu, C. Z., Hsiao, E. Y., Moore, M. J., & Patterson, P. H. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.01.011 · Cited by 662 · see citing works
Anxiety Disorders During Pregnancy and the Postpartum Period: A Systematic Review
Ross, L. E., & McLean, L. M. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0818 · Cited by 611 · see citing works
Fetal programming of hypothalamo‐pituitary‐adrenal function: prenatal stress and glucocorticoids
Kapoor, A., Dunn, E., Kostaki, A., Andrews, M. H., & Matthews, S. G. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.105254 · Cited by 598 · see citing works
Prenatal stress and the programming of the HPA axis
Glover, V., O’Connor, T. G., & O’Donnell, K. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.008 · Cited by 567 · see citing works
Self-citationKim, C. J., Romero, R. J., Chaemsaithong, P., & Kim, J.-S. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.08.041 · Cited by 520 · see citing works
Prenatal Stress and Neurodevelopment of the Child: Focus on the HPA Axis and Role of the Placenta
O’Donnell, K. J., O’Connor, T. G., & Glover, V. A. S. (2009) · Developmental Neuroscience · doi:10.1159/000216539 · Cited by 509 · see citing works
Self-citationMaternal Exposure to Toxoplasmosis and Risk of Schizophrenia in Adult Offspring
Brown, A. S., Schaefer, C. A., Quesenberry, C. P., Liu, L., Babulas, V. P., & Susser, E. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.4.767 · Cited by 490 · see citing works
Self-citationPrenatal Famine and Adult Health
Lumey, L. H., Stein, A. D., & Susser, E. (2011) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031210-101230 · Cited by 460 · see citing works
Maternal prenatal anxiety and downregulation of placental 11β-HSD2
O’Donnell, K. J., Bugge Jensen, A., Freeman, L., Khalife, N., O’Connor, T. G., & Glover, V. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.09.014 · Cited by 449 · see citing works
Self-citationThe Dutch hunger winter and the developmental origins of health and disease
Schulz, L. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012911107 · Cited by 438 · see citing works
The persisting effect of maternal mood in pregnancy on childhood psychopathology
O'Donnell, K. J., Glover, V., Barker, E. D., & O'Connor, T. G. (2014) · Development and Psychopathology · doi:10.1017/s0954579414000029 · Cited by 425 · see citing works
Self-citationLaplante, D. P., Brunet, A., Schmitz, N., Ciampi, A., & King, S. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31817eec80 · Cited by 424 · see citing works
Developmental timing and critical windows for the treatment of psychiatric disorders
Marín, O. (2016) · Nature Medicine · doi:10.1038/nm.4225 · Cited by 374 · see citing works
Maternal immune activation and autism spectrum disorder: From rodents to nonhuman and human primates
Careaga, M., Murai, T., & Bauman, M. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.10.020 · Cited by 348 · see citing works
Elevated maternal C-reactive protein and autism in a national birth cohort
Brown, A. S., Sourander, A., Hinkka-Yli-Salomäki, S., McKeague, I. W., Sundvall, J., & Surcel, H.-M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.197 · Cited by 343 · see citing works
Self-citationSkuse, D. H., Mandy, W. P. L., & Scourfield, J. (2005) · British Journal of Psychiatry · doi:10.1192/bjp.187.6.568 · Cited by 322 · see citing works
Influence of infection during pregnancy on fetal development
Adams Waldorf, K. M., & McAdams, R. M. (2013) · Reproduction · doi:10.1530/rep-13-0232 · Cited by 319 · see citing works
Maternal pre‐pregnancy obesity and child neurodevelopmental outcomes: a meta‐analysis
Sanchez, C. E., Barry, C., Sabhlok, A., Russell, K., Majors, A., Kollins, S. H., & Fuemmeler, B. F. (2018) · Obesity Reviews · doi:10.1111/obr.12643 · Cited by 304 · see citing works
Maternal Infection During Pregnancy and Autism Spectrum Disorders
Zerbo, O., Qian, Y., Yoshida, C., Grether, J. K., Van de Water, J., & Croen, L. A. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-2016-3 · Cited by 298 · see citing works
Maternal pregnancy-specific anxiety is associated with child executive function at 6–9 years age
Buss, C., Davis, E. P., Hobel, C. J., & Sandman, C. A. (2011) · Stress · doi:10.3109/10253890.2011.623250 · Cited by 289 · see citing works
Zerbo, O., Iosif, A.-M., Walker, C., Ozonoff, S., Hansen, R. L., & Hertz-Picciotto, I. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1540-x · Cited by 277 · see citing works
Schizophrenia Following Pre-natal Exposure to Influenza Epidemics Between 1939 and 1960
Sham, P. C., O’Callaghan, E., Takei, N., Murray, G. K., Hare, E. H., & Murray, R. M. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.160.4.461 · Cited by 250 · see citing works
Marques, A. H., O'Connor, T. G., Roth, C., Susser, E., & Bjørke-Monsen, A.-L. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00120 · Cited by 226 · see citing works
Self-citationInteractions of innate and adaptive immunity in brain development and function
Filiano, A. J., Gadani, S. P., & Kipnis, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.07.050 · Cited by 217 · see citing works
Christian, L. M., Franco, A., Glaser, R., & Iams, J. D. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.02.012 · Cited by 216 · see citing works
Short, S. J., Lubach, G. R., Karasin, A. I., Olsen, C. W., Styner, M., Knickmeyer, R. C., Gilmore, J. H., & Coe, C. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.026 · Cited by 202 · see citing works
Pre‐ and postnatal influences on preschool mental health: a large‐scale cohort study
Robinson, M., Oddy, W. H., Li, J., Kendall, G. E., de Klerk, N. H., Silburn, S., Zubrick, S. R., Newnham, J. P., Stanley, F. J., & Mattes, E. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01955.x · Cited by 190 · see citing works
Prenatal maternal stress predicts autism traits in 6½ year-old children: Project Ice Storm
Walder, D. J., Laplante, D. P., Sousa-Pires, A., Veru, F., Brunet, A., & King, S. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.04.034 · Cited by 183 · see citing works
Oddy, W. H., Allen, K. L., Trapp, G., Ambrosini, G. L., Black, L. J., Huang, R., Rzehak, P., Runions, K., Pan, F., Beilin, L. J., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.01.002 · Cited by 183 · see citing works
Schneider, M. L., Coe, C. L., & Lubach, G. R. (1992) · Developmental Psychobiology · doi:10.1002/dev.420250604 · Cited by 145 · see citing works
Bland, S. T., Beckley, J. T., Young, S., Tsang, V., Watkins, L. R., Maier, S. F., & Bilbo, S. D. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.012 · Cited by 136 · see citing works
Psychiatric Symptoms and Proinflammatory Cytokines in Pregnancy
Blackmore, E. R., Moynihan, J. A., Rubinow, D. R., Pressman, E. K., Gilchrist, M., & O’Connor, T. G. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31822fc277 · Cited by 132 · see citing works
Self-citationFetal origins of coronary heart disease.
Barker, D. J. (1993) · Heart · doi:10.1136/hrt.69.3.195 · Cited by 125 · see citing works
iPSYCH-SSI-Broad Autism Group, St Pourcain, B., Robinson, E. B., Anttila, V, Sullivan, B. B., Maller, J., Golding, J., Skuse, D., Ring, S., Evans, D. M., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2016.198 · Cited by 125 · see citing works
Zammit, S., Odd, D., Horwood, J. P., Thompson, A. D., Thomas, K. H., Menezes, P. R., Gunnell, D., Hollis, C. P., Dieter Wolke, C., Lewis, G., et al. (2009) · Psychological Medicine · doi:10.1017/s0033291708005126 · Cited by 123 · see citing works
Birtchnell, J., Evans, C., & Kennard, J. (1988) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1988.tb02787.x · Cited by 118 · see citing works
Zerbo, O., Yoshida, C. K., Grether, J. K., de Water, J. V., Ashwood, P., DeLorenze, G. N., Hansen, R. L., Kharrazi, M., & Croen, L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-113 · Cited by 116 · see citing works
Prenatal maternal stress from a natural disaster predicts dermatoglyphic asymmetry in humans
King, S., Mancini-Marı̈e, A., Brunet, A., Walker, E. F., Meaney, M. J., & Laplante, D. P. (2009) · Development and Psychopathology · doi:10.1017/s0954579409000364 · Cited by 112 · see citing works
A Nationwide Study on the Risk of Autism After Prenatal Stress Exposure to Maternal Bereavement
Li, J., Vestergaard, M., Obel, C., Christensen, J., Precht, D. H., Lu, M., & Olsen, J. (2009) · PEDIATRICS · doi:10.1542/peds.2008-1734 · Cited by 111 · see citing works
Croen, L., Qian, Y., Ashwood, P., Zerbo, O., Schendel, D., Pinto‐Martin, J. A., Fallin, M. D., Levy, S. E., Schieve, L. A., Yeargin‐Allsopp, M., et al. (2019) · Autism Research · doi:10.1002/aur.2175 · Cited by 106 · see citing works
Allswede, D. M., Yolken, R. H., Buka, S. L., & Cannon, T. D. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30006-7 · Cited by 97 · see citing works
Stefan Thurner, A., Klimek, P., Szell, M., Duftschmid, G., Endel, G., Kautzky‐Willer, A., & Kasper, D. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215626110 · Cited by 95 · see citing works
Collier, S. A., Rasmussen, S. A., Feldkamp, M. L., & Honein, M. A. (2009) · Birth Defects Research Part A: Clinical and Molecular Teratology · doi:10.1002/bdra.20540 · Cited by 94 · see citing works
Prenatal immune programming of the sex-dependent risk for major depression
Gilman, S. E., Cherkerzian, S., Buka, S. L., Hahn, J., Hornig, M., & Goldstein, J. M. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.91 · Cited by 81 · see citing works
Chorioamnionitis in the Pathogenesis of Brain Injury in Preterm Infants
Chau, V., McFadden, D. E., Poskitt, K. J., & Miller, S. P. (2013) · Clinics in Perinatology · doi:10.1016/j.clp.2013.10.009 · Cited by 80 · see citing works
Lee, Y. A., Cherkerzian, S., Seidman, L. J., Papandonatos, G. D., Savitz, D. A., Tsuang, M. T., Goldstein, J. M., & Buka, S. L. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.18101206 · Cited by 73 · see citing works
Patel, S., Dale, R. C., Rose, D. R., Heath, B. E., Nordahl, C. W., Rogers, S. J., Guastella, A. J., & Ashwood, P. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00976-2 · Cited by 70 · see citing works
O’Connor, T. G., Moynihan, J. A., & Caserta, M. T. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12187 · Cited by 64 · see citing works
Self-citationA Mouse Model of Term Chorioamnionitis Unraveling Causes of Adverse Neurological Outcomes
Burd, I. D., Brown, A. G., Gonzalez, J., Chai, J., & Elovitz, M. A. (2011) · Reproductive Sciences · doi:10.1177/1933719111398498 · Cited by 63 · see citing works
Self-citationMaternal fever during pregnancy and offspring attention deficit hyperactivity disorder
Gustavson, K., Ask, H., Ystrøm, E., Stoltenberg, C., Lipkin, W. I., Surén, P., Håberg, S. E., Magnus, P. M., Knudsen, G. P., Eilertsen, E. M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45920-7 · Cited by 61 · see citing works
Gestational cytokine concentrations and neurocognitive development at 7 years
Ghassabian, A., Albert, P. S., Hornig, M., Yeung, E. H., Cherkerzian, S., Goldstein, R. B., Buka, S. L., Goldstein, J. M., & Gilman, S. E. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0112-z · Cited by 56 · see citing works
Schizophrenia following prenatal exposure to influenza epidemics between 1939 and 1960
Curtis, D. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.161.5.712 · Cited by 51 · see citing works
Emack, J., & Matthews, S. G. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.08.008 · Cited by 43 · see citing works
Dodd, J. M., Deussen, A. R., Mohamad, İ., Rifas‐Shiman, S., Yelland, L., Louise, J., McPhee, A., Grivell, R. M., Owens, J. A., Gillman, M. W., et al. (2015) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.13796 · Cited by 39 · see citing works
Evidence for Developmental Programming of Cerebral Laterality in Humans
Jones, A., Osmond, C., Godfrey, K. M., & Phillips, D. I. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017071 · Cited by 38 · see citing works
White, T. J. H. (2019) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2019.02.010 · Cited by 33 · see citing works
Association of Maternal Influenza Vaccination During Pregnancy With Early Childhood Health Outcomes
Mehrabadi, A., Dodds, L. A., MacDonald, N. E., Top, K. A., Benchimol, E. I., Kwong, J. C., Ortiz, J. R., Sprague, A. E., Walsh, L. K., Wilson, K. R., et al. (2021) · JAMA · doi:10.1001/jama.2021.6778 · Cited by 26 · see citing works
Rasmussen, J. M., Graham, A. M., Gyllenhammer, L. E., Entringer, S., Chow, D. S., O’Connor, T. G., Fair, D. A., Wadhwa, P. D., & Buß, C. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.03.007 · Cited by 22 · see citing works
Self-citationEffects of prenatal bacterial infection on cognitive performance in early childhood
Lee, Y. H., Papandonatos, G. D., Savitz, D. A., Heindel, W. C., & Buka, S. L. (2020) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12603 · Cited by 21 · see citing works
Cochran, A. L., Pingeton, B. C., Goodman, S. H., Laurent, H. K., Rathouz, P. J., Newport, D. J., & Stowe, Z. N. (2020) · Journal of Abnormal Psychology · doi:10.1037/abn0000612 · Cited by 17 · see citing works
Placental Studies for Child Development
O’Connor, T. G., Miller, R. K., & Salafia, C. M. (2019) · Child Development Perspectives · doi:10.1111/cdep.12338 · Cited by 15 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
- Gluckman P., & Hanson M. (2005). The fetal matrix: Evolution, development, and disease. Cambridge University Press.
- McCullagh P., & Nelder J. A. (1998). Generalized linear models (2nd ed.). Chapman & Hall/CRC.
- Weschler D., Golombok J., & Rust J. (1992). WISC-III U.K. Weschler Intelligence Scale for Children U.K. manual (3rd ed.). The Psychological Corporation.
Cited by
Sorted by citations
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
Sznajder, K. K., Teti, D. M., & Kjerulff, K. H. (2022) · PLoS ONE · doi:10.1371/journal.pone.0272593 · Cited by 26 · see citing works
Complex Neuroimmune Involvement in Neurodevelopment: A Mini-Review
Monet, M. C., & Quan, N. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s410562 · Cited by 24 · see citing works
Maternal Immune Activation Hypotheses for Human Neurodevelopment: Some Outstanding Questions
O’Connor, T. G., & Ciesla, A. A. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.10.006 · Cited by 23 · see citing works
Self-citationPrenatal diurnal cortisol: Normative patterns and associations with affective symptoms and stress
Murphy, H. R., Gu, Y., Wu, Q., Brunner, J., Panisch, L. S., Best, M., Arnold, M. S., Duberstein, Z. T., Putzig, J., Carnahan, J. A., et al. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105856 · Cited by 24 · see citing works
Self-citationLähdepuro, A., Räikkönen, K., Pham, H., Thompson-Felix, T. M., Eid, R. S., O’Connor, T. G., Glover, V. A. S., Lahti, J. M. T., Heinonen, K., Wolford, E., et al. (2023) · Psychological Medicine · doi:10.1017/s0033291723003550 · Cited by 21 · see citing works
Self-citationRăchită, A. I. C., Strete, E. G., Sălcudean, A., Ghiga, D. V., Huţanu, A., Muntean, L. M., Suciu, L. M., & Mărginean, C. (2023) · Medicina · doi:10.3390/medicina59020339 · Cited by 20 · see citing works
Wei, Q., Xiao, Y., Yang, T., Chen, J., Chen, L., Wang, K., Zhang, J., Li, L., Jia, F., Wu, L., et al. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115789 · Cited by 16 · see citing works
Path analysis of influencing factors for anxiety and depression among first-trimester pregnant women
Li, W., Lin, L., Teng, S., Yang, Y., Li, L., Fang, P., Peng, D., Gao, X. Y., & Huang, G. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1440560 · Cited by 15 · see citing works
Lin, M., Pan, Y., Wu, C., Liu, C., Chen, P., Thompson, W. K., Fan, C. C., & Wang, S. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02787-z · Cited by 10 · see citing works
The placental tryptophan pathway across gestation: implications for pregnancy outcomes
Karahoda, R., Walker, D., Abad, C., Anandam, K. Y., Murthi, P., & Štaud, F. (2026) · Human Reproduction Update · doi:10.1093/humupd/dmag001 · Cited by 9 · see citing works
Mori, M., Nishigori, T., Ogata, Y., Suzuki, T., Satô, A., Murata, T., Kyozuka, H., Yamaguchi, A., Metoki, H., Shinohara, Y., et al. (2023) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174422000691 · Cited by 9 · see citing works
Gestational glyphosate exposure and early childhood neurodevelopment in a Puerto Rico birth cohort
Jenkins, H. M., Meeker, J. D., Zimmerman, E., Cathey, A. L., Fernandez, J. A., Montañez, G. H., Park, S., Pabón, Z. Y. R., Vélez-Vega, C. M., Cordero, J. F., et al. (2024) · Environmental Research · doi:10.1016/j.envres.2024.118114 · Cited by 10 · see citing works
Global Challenges After a Global Challenge: Lessons Learned from the COVID-19 Pandemic
Yazdanpanah, N., Sedikides, C., Ochs, H. D., Camargo, C. A., Darmstadt, G. L., Cerdà, A., Cauda, V., Peters, G. J., Sellke, F. W., Wong, N. D., et al. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-61939-7_1 · Cited by 5 · see citing works
Self-citationPrenatal maternal immune activation predicts observed fearfulness in infancy.
Serrano, J., Womack, S. R., Yount, C., Chowdhury, S. F., Arnold, M. S., Brunner, J., Duberstein, Z. T., Barrett, E. S., Scheible, K. M., Miller, R. K., et al. (2024) · Developmental Psychology · doi:10.1037/dev0001718 · Cited by 4 · see citing works
Self-citationKoutra, K., Mouatsou, C., Margetaki, K., Roumeliotaki, T., Mavroeides, G., Psoma, S., Kampouri, M., Karachaliou, M., Kogevinas, M., & Chatzi, L. (2025) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-025-02746-1 · Cited by 4 · see citing works
Kępińska, A. P., Robakis, T. K., Smout, S., Bercovitch, R., Cohen, L., Mahjani, I. C. G., Skalkidou, A., Bergink, V., & Mahjani, B. (2026) · Psychological Medicine · doi:10.1017/s0033291725103139 · Cited by 10 · see citing works
Reissland, N., Matthewson, J., & Einbeck, J. (2023) · Infant Behavior and Development · doi:10.1016/j.infbeh.2023.101823 · Cited by 3 · see citing works
The effects of lockdown during the COVID-19 pandemic on fetal movement profiles
Reissland, N., Ustun-Elayan, B., & Einbeck, J. (2024) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-024-06259-8 · Cited by 2 · see citing works
Establishment of Neurodevelopment in the First 1000 Days of Life
Mazaheri‐Tehrani, S., Bemanalizadeh, M., Poursafa, P., & Kelishadi, R. (2024) · Springer eBooks · doi:10.1007/978-981-97-7433-3_1 · Cited by 1 · see citing works
Moreno, M. G., Luján-Rodríguez, V. M., Baliyan, S., Poza, C., Capellán, R., Heras-Martinez, N. D. L., Morcillo, M. Á., Oteo, M., Ambrosio, E., Ucha, M., et al. (2025) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2025.100452 · Cited by 3 · see citing works
Baer, R. J., Oltman, S. P., Adeyemi, D., Amsalu, R., Blackman, K. C. A., Blebu, B. E., Coleman‐Phox, K., Felder, J. N., Gano, D. L., Lyndon, A., et al. (2025) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-025-08603-y · Cited by 1 · see citing works
What Are We Like, Is It a Matter of Genetic Inheritance or Not?Preprint
Mariano, S. (2023) · Qeios · doi:10.32388/2gz80s
Prenatal Risk and Later Intellectual and Developmental Disabilities
Bick, J. R., Rutter, T. M., Holland, C. M., Mueller, I., Mahmoodi, V., Manessis, A. G., Merrill, L. C., Camacho, M. C., Inala, S., Ortiz‐Jimenez, A., et al. (2024) · Contemporary clinical neuroscience · doi:10.1007/978-3-031-66932-3_8
What Are We Like: Is It a Matter of Genetic Inheritance or Not? A Systematic ReviewPreprint
Mariano, S. (2024) · Qeios · doi:10.32388/2gz80s.2
Furlan, R. H., Pike, M. R., Lipner, E., Breen, E. C., Cohn, B. A., Cirillo, P. M., Krigbaum, N. Y., Kring, A. M., Olino, T. M., Alloy, L. B., et al. (2024) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2024.100096
Duberstein, Z. T., Murphy, H. R., Wu, Q., Meng, Y., Wang, C., Smith, R., Salafia, C. M., Chowdhury, S. F., Barrett, E. S., Scheible, K. M., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120673
Self-citationClephane, K., Lorenz, T. K., Calkins, F. C., Phillips, E. M., & Brock, R. L. (2026) · Evolutionary Psychological Science · doi:10.1007/s40806-025-00459-x
Yue, J., Zhang, J., Yu, X., Li, Z., Wang, Y., Zhao, S., Bai, Y., Li, X., Li, H., Yang, Y., et al. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1809262
Khandakar, R., Harris, F., Carr, V. J., Green, M. J., & Watkeys, O. J. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106861
Rinne, G. R., Ross, K. M., & Schetter, C. D. (2026) · Developmental Psychobiology · doi:10.1002/dev.70186
- Authors
- O'Connor, T. G., Ciesla, A. A., Sefair, A. V., Thornburg, L. L., Brown, A. S., Glover, V., & O'Donnell, K. J.
- Affiliations
- New York State Psychiatric Institute (US)
- ORCID
- Venue
- Journal of Psychopathology and Clinical Science
- Published
- 2022-05
- Volume
- 131
- Issue
- 4
- Pages
- 422-434
- ISSN
- 2769-7541 (ISSN-L)
- 2769-755X
- PMC
- PMC9069845
- OpenAlex
- W4221121940
- Cited by
- 31
- References
- 75
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 11 · 2023: 7 · 2022: 2 · 2021: 1
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Psychopathology and Clinical Science (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (MH073842; UG3 OD023349)
- Wynne Center for Family Research
- Canada First Research Excellence Healthy Brains for Healthy Lives Initiative
- Brain & Behavior Research Foundation
- Fonds de recherche du Québec – Santé
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- prenatal infection, prenatal anxiety, maternal mental health, child neurodevelopment, autism spectrum disorder, attention deficits, anxiety symptoms, prenatal programming, middle childhood, perinatal risk
- MeSH terms
- Anxiety, Anxiety Disorders, Child, Child Behavior Disorders, Female, Humans, Longitudinal Studies, Pregnancy, Prospective Studies, Vitamins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
