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Cited by 279

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Factors contributing to the outcome of oxidative damage to nucleic acids

Evans, Mark D., Cooke, Marcus S.·2004·BioEssays

Abstract

Oxidative damage to DNA appears to be a factor in cancer, yet explanations for why highly elevated levels of such lesions do not always result in cancer remain elusive. Much of the genome is non‐coding and lesions in these regions might be expected to have little biological effect, an inference supported by observations that there is preferential repair of coding sequences. RNA has an important coding function in protein synthesis, and yet the consequences of RNA oxidation are largely unknown. Some non‐coding nucleic acid is functional, e.g. promoters, and damage to these sequences may well have biological consequences. Similarly, oxidative damage to DNA may promote microsatellite instability, inhibit methylation and accelerate telomere shortening. DNA repair appears pivotal to the maintenance of genome integrity, and genetic alterations in repair capacity, due to single nucleotide polymorphisms or mutation, may account for inter‐individual differences in cancer susceptibility. This review will survey these aspects of oxidative damage to nucleic acids and their implication for disease. BioEssays 26:533–542, 2004. © 2004 Wiley Periodicals, Inc.

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Metadata

Authors
Evans, M. D., & Cooke, M. S.
Venue
BioEssays
Publisher
Wiley
Published
2004-04-21
Volume
26
Issue
5
Pages
533-542
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
OpenAlex
W2013133552
Cited by
279
References
65
FWCI
0.75
Type
journal article
Language
en
Open access
closed

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