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Cited by 271

The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.

Eye development: a view from the retina pigmented epithelium

Ramón Martínez‐Morales, Juan, Rodrigo, Isabel, Bovolenta, Paola·2004·BioEssays
DOI 10.1002/bies.20064
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Abstract

The retina pigment epithelium (RPE) is a highly specialised epithelium that serves as a multifunctional and indispensable component of the vertebrate eye. Although a great deal of attention has been paid to its transdifferentiation capabilities and its ancillary functions in neural retina development, little is known about the molecular mechanisms that specify the RPE itself. Recent advances in our understanding of the genetic network that controls the progressive specification of the eye anlage in vertebrates have provided some of the initial cues to the mechanisms responsible for RPE patterning. Here, we have outlined many recent findings that suggest that a limited number of transcription factors, including Otx2, Mitf and Pax6 and a few signalling cascades, are the elements required for the onset of RPE specification in vertebrates. Furthermore, using this information and the data available on the specification of the pigmented cells of primitive chordates, we have ventured some hypotheses on the origin of RPE cells during evolution. BioEssays 26:766–777, 2004. © 2004 Wiley Periodicals, Inc.

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Metadata

Authors
Ramón Martínez‐Morales, J., Rodrigo, I., & Bovolenta, P.
Venue
BioEssays
Publisher
Wiley
Published
2004-06-21
Volume
26
Issue
7
Pages
766-777
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
DOI
10.1002/bies.20064
OpenAlex
W1976343564
Cited by
271
References
98
FWCI
0.77
Type
journal article
Language
en
Open access
closed

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