The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Opposing FGF and retinoid pathways: a signalling switch that controls differentiation and patterning onset in the extending vertebrate body axis
Abstract
Construction of the trunk/caudal region of the vertebrate embryo involves a set of distinct molecules and processes whose relationships are just coming into focus. In addition to the subdivision of the embryo into head and trunk domains, this “caudalisation” process requires the establishment and maintenance of a stem zone. This sequentially generates caudal tissues over a long period which then undergo differentiation and patterning in the extending body axis. Here we review recent studies that show that changes in the signalling properties of the paraxial mesoderm act as a switch that controls onset of differentiation and pattern in the spinal cord. These findings identify distinct roles for different caudalising factors; in particular, Fibroblast Growth Factor (FGF) inhibits differentiation in the caudal stem zone, while Retinoic acid (RA) provided rostrally by somitic mesoderm is required for neuronal differentiation and establishment of ventral neural pattern. Furthermore, the mutual opposition of FGF and RA pathways controls not only neural differentiation but also mesoderm segmentation and might also underlie the progressive assignment of rostrocaudal identity by regulating Hox gene availability and activation. BioEssays 26:857–869, 2004. © 2004 Wiley Periodicals, Inc.
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Cites
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Cited by
Retinoic acid in the development, regeneration and maintenance of the nervous system
Maden, M. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2212 · Cited by 896
Retinoic acid signalling during development
Rhinn, M., & Dollé, P. (2012) · Development · doi:10.1242/dev.065938 · Cited by 849
Retinoic acid in development: Towards an integrated view
Niederreither, K., & Dollé, P. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2340 · Cited by 726
Vitamin A in Reproduction and Development
Clagett-Dame, M., & Knutson, D. (2011) · Nutrients · doi:10.3390/nu3040385 · Cited by 439
Hox Genes: Choreographers in Neural Development, Architects of Circuit Organization
Philippidou, P., & Dasen, J. S. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.020 · Cited by 423
Metadata
- Authors
- del Corral, R. D., & Storey, K. G.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2004-07-19
- Volume
- 26
- Issue
- 8
- Pages
- 857-869
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W1989965266
- Cited by
- 298
- References
- 99
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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