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Cited by 298

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

Opposing FGF and retinoid pathways: a signalling switch that controls differentiation and patterning onset in the extending vertebrate body axis

del Corral, Ruth Diez, Storey, Kate G.·2004·BioEssays
DOI 10.1002/bies.20080
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Abstract

Construction of the trunk/caudal region of the vertebrate embryo involves a set of distinct molecules and processes whose relationships are just coming into focus. In addition to the subdivision of the embryo into head and trunk domains, this “caudalisation” process requires the establishment and maintenance of a stem zone. This sequentially generates caudal tissues over a long period which then undergo differentiation and patterning in the extending body axis. Here we review recent studies that show that changes in the signalling properties of the paraxial mesoderm act as a switch that controls onset of differentiation and pattern in the spinal cord. These findings identify distinct roles for different caudalising factors; in particular, Fibroblast Growth Factor (FGF) inhibits differentiation in the caudal stem zone, while Retinoic acid (RA) provided rostrally by somitic mesoderm is required for neuronal differentiation and establishment of ventral neural pattern. Furthermore, the mutual opposition of FGF and RA pathways controls not only neural differentiation but also mesoderm segmentation and might also underlie the progressive assignment of rostrocaudal identity by regulating Hox gene availability and activation. BioEssays 26:857–869, 2004. © 2004 Wiley Periodicals, Inc.

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Metadata

Authors
del Corral, R. D., & Storey, K. G.
Venue
BioEssays
Publisher
Wiley
Published
2004-07-19
Volume
26
Issue
8
Pages
857-869
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
DOI
10.1002/bies.20080
OpenAlex
W1989965266
Cited by
298
References
99
FWCI
1.05
Type
journal article
Language
en
Open access
closed

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