Why does the brain (not) have glycogen?

DiNuzzo, Mauro; Maraviglia, Bruno; Giove, Federico

doi:10.1002/bies.201000151

Cited by 53Neuroscience and Neuropharmacology ResearchGlycogen Storage Diseases and MyoclonusMetabolism, Diabetes, and Cancer

Why does the brain (not) have glycogen?

DiNuzzo, Mauro, Maraviglia, Bruno, Giove, Federico·2011·BioEssays

DOI 10.1002/bies.201000151

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Abstract

In the present paper we formulate the hypothesis that brain glycogen is a critical determinant in the modulation of carbohydrate supply at the cellular level. Specifically, we propose that mobilization of astrocytic glycogen after an increase in AMP levels during enhanced neuronal activity controls the concentration of glucose phosphates in astrocytes. This would result in modulation of glucose phosphorylation by hexokinase and upstream cell glucose uptake. This mechanism would favor glucose channeling to activated neurons, supplementing the already rich neuron-astrocyte metabolic and functional partnership with important implications for the energy compounds used to sustain neuronal activity. The hypothesis is based on recent modeling evidence suggesting that rapid glycogen breakdown can profoundly alter the short-term kinetics of glucose delivery to neurons and astrocytes. It is also based on review of the literature relevant to glycogen metabolism during physiological brain activity, with an emphasis on the metabolic pathways identifying both the origin and the fate of this glucose reserve.

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The local input-output balance between neuronal synaptic/spiking (or subthreshold/suprathreshold) activity is a primary determinant in the upregulation of aerobic glycolysis.
“Based on experimental evidence and metabolic modeling, we have previously proposed that the local input–output balance between neuronal synaptic/spiking (or subthreshold/suprathreshold) activity is a primary determinant in the upregulation of aerobic glycolysis (DiNuzzo and Giove, 2012; DiNuzzo et al., 2011; DiNuzzo and Nedergaard, 2017).”
From Perception is associated with the brain’s metabolic response to sensory stimulation (2022) · cites this paper as DiNuzzo et al., 2011

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“8 metabolic modeling, we have previously proposed that the local input-output balance between 153 neuronal synaptic/spiking (or subthreshold/suprathreshold) activity is a primary determinant in 154 the up-regulation of aerobic glycolysis (DiNuzzo and Giove 2012; DiNuzzo et al. 2011; DiNuzzo 155 and Nedergaard 2017).”
Background
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Authors: DiNuzzo, M., Maraviglia, B., & Giove, F.
Affiliations: Sapienza University of Rome (IT)
Fondazione Santa Lucia (IT)
Centro Ricerche Enrico Fermi (IT)
Corresponding author: DiNuzzo, Mauro
ORCID: DiNuzzo, Mauro
Maraviglia, Bruno
Giove, Federico
Venue: BioEssays
Publisher: Wiley
Published: 2011-02-21
Volume: 33
Issue: 5
Pages: 319-326
ISSN: 0265-9247 (ISSN-L)
1521-1878
DOI: 10.1002/bies.201000151
OpenAlex: W1974166540
Cited by: 53
References: 79
Citations by year: 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 7 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 6 · 2012: 9
FWCI: 0.73
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: BioEssays (publishedVersion)
PubMed (publishedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: brain glycogen, astrocytes, glycogen mobilization, AMP, glucose phosphorylation, hexokinase, glucose uptake, neuronal energy metabolism, glycogen metabolism
MeSH terms: Animals, Astrocytes, Brain, Gluconeogenesis, Glycogen, Humans, Models, Biological, Neurons, Phosphorylation

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