The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The evolution of menstruation: A new model for genetic assimilation: Explaining molecular origins of maternal responses to fetal invasiveness
Open accessAbstract
Why do humans menstruate while most mammals do not? Here, we present our answer to this long‐debated question, arguing that (i) menstruation occurs as a mechanistic consequence of hormone‐induced differentiation of the endometrium (referred to as spontaneous decidualization, or SD); (ii) SD evolved because of maternal–fetal conflict; and (iii) SD evolved by genetic assimilation of the decidualization reaction, which is induced by the fetus in non‐menstruating species. The idea that menstruation occurs as a consequence of SD has been proposed in the past, but here we present a novel hypothesis on how SD evolved. We argue that decidualization became genetically stabilized in menstruating lineages, allowing females to prepare for pregnancy without any signal from the fetus. We present three models for the evolution of SD by genetic assimilation, based on recent advances in our understanding of the mechanisms of endometrial differentiation and implantation. Testing these models will ultimately shed light on the evolutionary significance of menstruation, as well as on the etiology of human reproductive disorders like endometriosis and recurrent pregnancy loss.
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Cites
Developmental Plasticity and Evolution
West-Eberhard, M. J. (2003) · doi:10.1093/oso/9780195122343.001.0001 · Cited by 6,115
Genetic conflicts in human pregnancy
Haig, D. (1993) · The Quarterly Review of Biology · doi:10.1086/418300 · Cited by 1,253 · cited 10×
“Placental lactogen, one of the most abundant placental hormones, has been cited as a likely candidate [21].”
BackgroundInfluentialComparative Placentation: Structures, Functions and Evolution
Wooding, P., & Burton, G. (2008) · doi:10.1007/978-3-540-78797-6 · Cited by 228
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Self-citationMapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro
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Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle
Wang, W., Vilella, F., Alama, P., Moreno, I., Mignardi, M., Isakova, A., Pan, W., Simon, C., & Quake, S. R. (2020) · Nature Medicine · doi:10.1038/s41591-020-1040-z · Cited by 614
Menstruation: science and society
Critchley, H. O. D., Babayev, E., Bulun, S. E., Clark, S., Garcia-Grau, I., Gregersen, P. K., Kilcoyne, A., Kim, J.-Y. J., Lavender, M., Marsh, E. E., et al. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.06.004 · Cited by 448
Self-citationEndometrial Decidualization: The Primary Driver of Pregnancy Health
Ng, S.-W., Norwitz, G. A., Pavlicev, M., Tilburgs, T., Simón, C., & Norwitz, E. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114092 · Cited by 355
Uterine Selection of Human Embryos at Implantation
Brosens, J. J., Salker, M. S., Teklenburg, G., Nautiyal, J., Salter, S., Lucas, E. S., Steel, J. H., Christian, M., Chan, Y.-W., Boomsma, C. M., et al. (2014) · Scientific Reports · doi:10.1038/srep03894 · Cited by 329
The Human Endometrium as a Sensor of Embryo Quality1
Macklon, N. S., & Brosens, J. J. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.122846 · Cited by 317
(2020) · doi:10.1038/s42003-020-0763-1 · Cited by 309
Dyson, M. T., Roqueiro, D., Monsivais, D., Ercan, C. M., Pavone, M. E., Brooks, D. C., Kakinuma, T., Ono, M., Jafari, N., Dai, Y., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004158 · Cited by 211
The regulation of adipose tissue health by estrogens
Steiner, B. M., & Berry, D. C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.889923 · Cited by 171
Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium
Yamaguchi, M., Nakaoka, H., Suda, K., Yoshihara, K., Ishiguro, T., Yachida, N., Saito, K., Ueda, H., Sugino, K., Mori, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28568-2 · Cited by 54
The evolutionary biology of endometriosis
Dinsdale, N., Nepomnaschy, P., & Crespi, B. (2021) · Evolution, Medicine, and Public Health · doi:10.1093/emph/eoab008 · Cited by 53
Ellery, S. J., Walker, D. W., & Dickinson, H. (2016) · Amino Acids · doi:10.1007/s00726-016-2199-y · Cited by 39
Dyson, M. T., Kakinuma, T., Pavone, M. E., Monsivais, D., Navarro, A., Malpani, S. S., Ono, M., & Bulun, S. E. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.06.046 · Cited by 37
Metadata
- Authors
- Emera, D., Romero, R., & Wagner, G.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2011-11-07
- Volume
- 34
- Issue
- 1
- Pages
- 26-35
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W1580854767
- Cited by
- 176
- References
- 3
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- green
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