Exploiting human and mouse transcriptomic data: Identification of circadian genes and pathways influencing health
Open accessAbstract
The power of the application of bioinformatics across multiple publicly available transcriptomic data sets was explored. Using 19 human and mouse circadian transcriptomic data sets, we found that NR1D1 and NR1D2 which encode heme-responsive nuclear receptors are the most rhythmic transcripts across sleep conditions and tissues suggesting that they are at the core of circadian rhythm generation. Analyzes of human transcriptomic data show that a core set of transcripts related to processes including immune function, glucocorticoid signalling, and lipid metabolism is rhythmically expressed independently of the sleep-wake cycle. We also identify key transcripts associated with transcription and translation that are disrupted by sleep manipulations, and through network analysis identify putative mechanisms underlying the adverse health outcomes associated with sleep disruption, such as diabetes and cancer. Comparative bioinformatics applied to existing and future data sets will be a powerful tool for the identification of core circadian- and sleep-dependent molecules.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The SCN influence sleep-wake cycles that themselves influence circadian rhythmicity and partially dictate feed-fast behavior, which is believed to be a key synchronizer of peripheral clocks.
“Furthermore, the SCN influence sleep-wake cycles that themselves influence circadian rhythmicity (17) and partially dictate feed-fast behavior, which is believed to be a key synchronizer of peripheral clocks (see below).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [17]
Analysis of multiple human and mouse transcriptomic data sets highlights a close linkage between circadian rhythms and metabolic gene expression.
“Analysis of multiple human and mouse transcriptomic data sets highlights the close linkage between circadian rhythms and metabolic gene expression (17).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Regulation and Function of NF-κB Transcription Factors in the Immune System
Vallabhapurapu, S., & Karin, M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132641 · Cited by 2,578 · see citing works
A circadian gene expression atlas in mammals: Implications for biology and medicine
Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304 · see citing works
Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198 · see citing works
WebGestalt: an integrated system for exploring gene sets in various biological contexts
Zhang, B., Kirov, S. A., & Snoddy, J. R. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki475 · Cited by 1,801 · see citing works
WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013
Wang, J., Duncan, D. T., Shi, Z., & Zhang, B. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt439 · Cited by 1,502 · see citing works
Transcriptional architecture and chromatin landscape of the core circadian clock in mammals
Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S. (2012) · Science · doi:10.1126/science.1226339 · Cited by 1,464 · see citing works
Activating ESR1 mutations in hormone-resistant metastatic breast cancer
Robinson, D. R., Wu, Y.-M., Vats, P., Su, F., Lonigro, R. J., Cao, X., Kalyana-Sundaram, S., Wang, R., Ning, Y., Hodges, L., et al. (2013) · Nature Genetics · doi:10.1038/ng.2823 · Cited by 1,145 · see citing works
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
Rutter, J., Reick, M., Wu, L. C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060698 · Cited by 1,059 · see citing works
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
Cho, H., Zhao, X., Hatori, M., Yu, R. T., Barish, G. D., Lam, M. T., Chong, L.-W., DiTacchio, L., Atkins, A. R., Glass, C. K., et al. (2012) · Nature · doi:10.1038/nature11048 · Cited by 1,037 · see citing works
The Role of the Transcription Factor CREB in Immune Function
Wen, A. Y., Sakamoto, K. M., & Miller, L. S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001829 · Cited by 865 · see citing works
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
Malik, S., & Roeder, R. G. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2901 · Cited by 730 · see citing works
Harmonics of Circadian Gene Transcription in Mammals
Hughes, M. E., DiTacchio, L., Hayes, K. R., Vollmers, C., Pulivarthy, S. R., Baggs, J. E., Panda, S., & Hogenesch, J. B. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000442 · Cited by 674 · see citing works
Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
Li, J. Z., Bunney, B. G., Meng, F., Hagenauer, M. H., Walsh, D. M., Vawter, M. P., Evans, S. J., Choudary, P. V., Cartagena, P., Barchas, J. D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305814110 · Cited by 589 · see citing works
Möller-Levet, C. S., Archer, S. N., Bucca, G., Laing, E. E., Slak, A., Kabiljo, R., Lo, J. C. Y., Santhi, N., von Schantz, M., Smith, C. P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217154110 · Cited by 576 · see citing works
Self-citationIdentification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ
Raghuram, S., Stayrook, K. R., Huang, P., Rogers, P. M., Nosie, A. K., McClure, D. B., Burris, L. L., Khorasanizadeh, S., Burris, T. P., & Rastinejad, F. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1344 · Cited by 560 · see citing works
Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic functionPreprint
Bugge, A. K., Feng, D., Everett, L. J., Briggs, E. R., Mullican, S. E., Wang, F., Jager, J., & Lazar, M. A. (2012) · Genes & Development · doi:10.1101/gad.186858.112 · Cited by 503 · see citing works
Dijk, D., Duffy, J. F., Riel, E., Shanahan, T. L., & Czeisler, C. A. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0611v.x · Cited by 467 · see citing works
Self-citationMistimed sleep disrupts circadian regulation of the human transcriptome
Archer, S. N., Laing, E. E., Möller-Levet, C. S., van der Veen, D. R., Bucca, G., Lazar, A. S., Santhi, N., Slak, A., Kabiljo, R., von Schantz, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316335111 · Cited by 386 · see citing works
Self-citationCircaDB: a database of mammalian circadian gene expression profiles
Pizarro, A., Hayer, K. E., Lahens, N. F., & Hogenesch, J. B. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1161 · Cited by 367 · see citing works
Homer1a is a core brain molecular correlate of sleep loss
Maret, S., Dorsaz, S., Gurcel, L., Pradervand, S., Petit, B., Pfister, C., Hagenbüchle, O., O’Hara, B. F., Franken, P., & Tafti, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710131104 · Cited by 366 · see citing works
The role of intratumoral and systemic IL-6 in breast cancer
Dethlefsen, C., Højfeldt, G. W., & Højman, P. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2488-z · Cited by 363 · see citing works
The histone methyltransferase MLL1 permits the oscillation of circadian gene expression
Katada, S., & Sassone‐Corsi, P. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1961 · Cited by 291 · see citing works
A human immunodeficiency caused by mutations in the PIK3R1 gene
Deau, M., Heurtier, L., Frange, P., Suárez, F., Bôle‐Feysot, C., Nitschké, P., Cavazzana, M., Pïcard, C., Durandy, A., Fischer, A., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75746 · Cited by 289 · see citing works
Clocks, metabolism, and the epigenome
Feng, D., & Lazar, M. A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.026 · Cited by 271 · cited 1× · see citing works
“TheNR1Ds/REVERBs alsodrivethecircadianrecruitmentofthedeacetylaseHDAC3, thusregulatingtherhythmicmodificationofchromatinand consequentrepressionoftranscriptionatREVERBbinding sites[11,12].”
Circadian Desynchrony Promotes Metabolic Disruption in a Mouse Model of Shiftwork
Barclay, J. L., Husse, J., Bode, B., Naujokat, N., Meyer-Kovac, J., Schmid, S. M., Lehnert, H., & Oster, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037150 · Cited by 259 · see citing works
The TRAP/SMCC/Mediator complex and thyroid hormone receptor function
Ito, M., & Roeder, R. G. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00355-6 · Cited by 256 · see citing works
Isojima, Y., Nakajima, M., Ukai, H., Fujishima, H., Yamada, R. G., Masumoto, K., Kiuchi, R., Ishida, M., Ukai‐Tadenuma, M., Minami, Y., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908733106 · Cited by 246 · see citing works
CREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesis
Oh, K., Han, H.-S., Kim, M.-J., & Koo, S. (2013) · BMB Reports · doi:10.5483/bmbrep.2013.46.12.248 · Cited by 221 · see citing works
Noninvasive method for assessing the human circadian clock using hair follicle cells
Akashi, M., Soma, H., Yamamoto, T., Tsugitomi, A., Yamashita, S., Yamamoto, T., Nishida, E., Yasuda, A., Liao, J. K., & Node, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003878107 · Cited by 192 · see citing works
Essential roles of CKIδ and CKIε in the mammalian circadian clock
Lee, H.-M., Chen, R., Lee, Y., Yoo, S. H., & Lee, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906651106 · Cited by 172 · see citing works
Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat
Rodríguez, D. A., Rojas‐Rivera, D., & Hetz, C. A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.11.012 · Cited by 160 · see citing works
Phenotype of the Taurine Transporter Knockout Mouse
Warskulat, U., Heller‐Stilb, B., Oermann, E., Zilles, K., Haas, H. L., Lang, F. J. W., & Häussinger, D. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)28025-5 · Cited by 155 · see citing works
Zhu, Y. L., Stevens, R. G., Hoffman, A. E., Tjønneland, A. M., Vogel, U. B., Zheng, T., & Hansen, J. (2011) · Chronobiology International · doi:10.3109/07420528.2011.618896 · Cited by 155 · see citing works
Svensson, C., Ceder, J. A., Iglesias‐Gato, D., Chuan, Y.-C., Pang, S., Bjartell, A. S., Merino-Martinez, R., Bott, L., Helczynski, L., Ulmert, D., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt921 · Cited by 154 · see citing works
Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled
Cong, F., Schweizer, L., & VARMUS, H. E. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.2000-2011.2004 · Cited by 142 · see citing works
Genetic Evidence for a Role of CREB in Sustained Cortical Arousal
Graves, L. A., Hellman, K. M., Veasey, S. C., Blendy, J. A., Pack, A. I., & Abel, T. G. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00882.2002 · Cited by 124 · see citing works
The Pharmacogenetics of Type 2 Diabetes: A Systematic Review
Maruthur, N. M., Gribble, M. O., Bennett, W. L., Bolen, S. D., Wilson, L. M., Balakrishnan, P., Sahu, A., Bass, E. B., Kao, W. H. L., & Clark, J. M. (2014) · Diabetes Care · doi:10.2337/dc13-1276 · Cited by 117 · see citing works
CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers
Ramdzan, Z. M., & Nepveu, A. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3805 · Cited by 113 · see citing works
PIK3R1 underexpression is an independent prognostic marker in breast cancer
Čížková, M., Vacher, S., Meseure, D., Trassard, M., Susini, A., Mlcuchova, D., Callens, C., Rouleau, É., Spyratos, F., Lidereau, R., et al. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-545 · Cited by 111 · see citing works
Ramanathan, C., Xu, H., Khan, S. K., Shen, Y., Gitis, P. J., Welsh, D. K., Hogenesch, J. B., & Liu, A. C. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004244 · Cited by 108 · see citing works
Regulation of Casein Kinase Iϵ Activity by Wnt Signaling
Swiatek, W., Tsai, I.-C., Klimowski, L., Pepler, A., Barnette, J. E., Yost, H. J., & Virshup, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m304682200 · Cited by 106 · see citing works
Mahlknecht, U., Will, J., Varin, A., Hoelzer, D. F., & Herbein, G. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3979 · Cited by 89 · see citing works
CREB Influences Timing and Entrainment of the SCN Circadian Clock
Lee, B., Li, A., Hansen, K. F., Cao, R., Yoon, J. H., & Obrietan, K. H. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410381229 · Cited by 84 · see citing works
Zhou, H., Ma, H., Wei, W., Ji, D., Song, X., Sun, J., Zhang, J., & Li, J. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.186 · Cited by 80 · see citing works
Sugiyama, Y., Hatano, N., Sueyoshi, N., Suetake, I., Tajima, S., Kinoshita, E., Kinoshita‐Kikuta, E., Koike, T., & Kameshita, I. (2010) · Biochemical Journal · doi:10.1042/bj20091856 · Cited by 67 · see citing works
Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling
Magnani, L., & Lupien, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.04.026 · Cited by 66 · see citing works
MAL Protein Controls Protein Sorting at the Supramolecular Activation Cluster of Human T Lymphocytes
Antón, O. M., Andrés‐Delgado, L., Reglero-Real, N., Batista, A., & Alonso, M. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003771 · Cited by 62 · see citing works
RAS Transformation Requires CUX1-Dependent Repair of Oxidative DNA Damage
Ramdzan, Z. M., Vadnais, C., Pal, R., Vandal, G., Cadieux, C., Leduy, L., Davoudi, S., Hulea, L., Yao, L., Karnezis, A. N., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001807 · Cited by 62 · see citing works
Li, B. E., & Ernst, P. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2014.09.006 · Cited by 59 · see citing works
McCurdy, C. E., Schenk, S., Holliday, M., Philp, A., Houck, J. A., Patsouris, D., MacLean, P. S., Majka, S. M., Klemm, D. J., & Friedman, J. E. (2012) · Diabetes · doi:10.2337/db11-1433 · Cited by 59 · see citing works
PPARα attenuates the proinflammatory response in activated mesangial cells
Kono, K., Kamijo, Y., Hora, K., Takahashi, K., Higuchi, M., Kiyosawa, K., Shigematsu, H., Gonzalez, F. J., & Aoyama, T. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00484.2007 · Cited by 53 · see citing works
Bouchal, J., Santer, F. R., Höschele, P. P. S., Tomaštíková, E. D., Neuwirt, H., & Čulig, Z. (2010) · The Prostate · doi:10.1002/pros.21257 · Cited by 50 · see citing works
Hasegawa, N., Sumitomo, A., Fujita, A., Aritome, N., Mizuta, S., Matsui, K., Ishino, R., Inoue, K., Urahama, N., Nose, J., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.05245-11 · Cited by 48 · see citing works
Baron, D., Bihouée, A., Teusan, R., Dubois, E., Savagner, F., Steenman, M., Houlgatte, R., & Ramstein, G. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btq710 · Cited by 43 · see citing works
c-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cells
Geismann, C., Grohmann, F., Sebens, S., Wirths, G., Dreher, A., Häsler, R., Rosenstiel, P. C., Hauser, C., Egberts, J.-H., Trauzold, A., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.417 · Cited by 39 · see citing works
Iizuka, K., Wu, W., Horikawa, Y., Saito, M., & Takeda, J. (2013) · Endocrine Journal · doi:10.1507/endocrj.ej13-0079 · Cited by 38 · see citing works
Casein kinase I / phosphorylates topoisomerase II at serine-1106 and modulates DNA cleavage activity
Grozav, A. G., Chikamori, K., Kozuki, T., Grabowski, D., Bukowski, R. M., Willard, B. B., Kinter, M. T., Andersen, A. H., Ganapathi, R. N., & Ganapathi, M. K. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn934 · Cited by 35 · see citing works
Luce, M. J., & Burrows, P. D. (1999) · Gene · doi:10.1016/s0378-1119(99)00093-1 · Cited by 33 · see citing works
Photic Phase-Response Curve in 2 Strains of Mice with Impaired Responsiveness to Estrogens
Blattner, M. S., & Mahoney, M. M. (2013) · Journal of Biological Rhythms · doi:10.1177/0748730413497190 · Cited by 33 · see citing works
Role of NRSF/REST in the Regulation of Cardiac Gene Expression and Function
Kuwahara, K. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-1210 · Cited by 28 · see citing works
Blattner, M. S., & Mahoney, M. M. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00831.x · Cited by 26 · see citing works
Spatial Learning of Mice Lacking a Neuron-Specific Epidermal Growth Factor Family Protein, NELL2
Matsuyama, S., Doe, N., Kurihara, N., Tanizawa, K., Kuroda, S., Iso, H., & Horie, M. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0050211 · Cited by 23 · see citing works
Omnus, D. J., Mehrtens, S. H., Ritter, B., Resch, K., Yamada, M., Frank, R., Nourbakhsh, M., & Reboll, M. R. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.01.050 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Circadian rhythms, metabolism, and chrononutrition in rodents and humans
Johnston, J. D., Ordovás, J. M., Scheer, F. A., & Turek, F. W. (2016) · Advances in Nutrition · doi:10.3945/an.115.010777 · Cited by 258 · see citing works
Self-citationFlanagan, A., Bechtold, D. A., Pot, G. K., & Johnston, J. D. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15246 · Cited by 245 · see citing works
Self-citationKervezee, L., Kosmadopoulos, A., & Boivin, D. B. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14216 · Cited by 216 · see citing works
Archer, S. N., & Oster, H. (2015) · Journal of Sleep Research · doi:10.1111/jsr.12307 · Cited by 171 · see citing works
Self-citationBlood transcriptome based biomarkers for human circadian phase
Laing, E., Möller‐Levet, C. S., Poh, N., Santhi, N., Archer, S. N., & Dijk, D. (2017) · eLife · doi:10.7554/elife.20214 · Cited by 161 · see citing works
Self-citationTranscriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle
Perrin, L., Loizides-Mangold, U., Chanon, S., Gobet, C., Hulo, N., Isenegger, L., Weger, B. D., Migliavacca, E., Charpagne, A., Betts, J. A., et al. (2018) · eLife · doi:10.7554/elife.34114 · Cited by 139 · see citing works
Self-citationKervezee, L., Cuesta, M., Cermakian, N., & Boivin, D. B. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720719115 · Cited by 136 · see citing works
Developing Biomarker Arrays Predicting Sleep and Circadian-Coupled Risks to Health
Mullington, J. M., Abbott, S. M., Carroll, J. E., Davis, C. J., Dijk, D.-J., Dinges, D. F., Gehrman, P. R., Ginsburg, G. S., Gozal, D., Haack, M., et al. (2016) · Sleep · doi:10.5665/sleep.5616 · Cited by 105 · see citing works
Self-citationArcher, S. N., Schmidt, C., Vandewalle, G., & Dijk, D. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.10.008 · Cited by 100 · see citing works
Self-citationChristou, S., Wehrens, S. M. T., Isherwood, C., Möller‐Levet, C. S., Wu, H., Revell, V. L., Bucca, G., Skene, D. J., Laing, E., Archer, S. N., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-39668-3 · Cited by 91 · see citing works
Self-citationZeitgebers and their association with rest-activity patterns
Quante, M., Mariani, S., Weng, J. F., Marinac, C. R., Kaplan, E. R., Rueschman, M., Mitchell, J. A., James, P., Hipp, J. A., Feliciano, E. M. C., et al. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1527347 · Cited by 70 · see citing works
Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity
Cunningham, P. S., Ahern, S. A., Smith, L. C., Santos, C. S. D. S., Wager, T. T., & Bechtold, D. A. (2016) · Scientific Reports · doi:10.1038/srep29983 · Cited by 42 · see citing works
Masi, D., Spoltore, M. E., Rossetti, R., Watanabe, M., Tozzi, R., Caputi, A., Risi, R., Balena, A., Gandini, O., Mariani, S., et al. (2022) · Nutrients · doi:10.3390/nu14071410 · Cited by 42 · see citing works
The functional and predictive roles of miR-210 in cryptorchidism
Duan, Z., Huang, H., & Sun, F. (2016) · Scientific Reports · doi:10.1038/srep32265 · Cited by 33 · see citing works
Möller-Levet, C., Laing, E., Archer, S., & Dijk, D. (2022) · BMC Biology · doi:10.1186/s12915-022-01258-7 · Cited by 20 · see citing works
Self-citationOmics Approaches in Sleep-Wake Regulation
O’Callaghan, E. K., Green, E. W., Franken, P., & Mongrain, V. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_125 · Cited by 16 · see citing works
Miao, B., Niu, S., Wu, R., Liang, Z., & Zhai, Y. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2021.824533 · Cited by 15 · see citing works
Morales-Lara, D., De-la-Peña, C., & Murillo-Rodríguez, E. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0409-6 · Cited by 14 · see citing works
Mining for novel candidate clock genes in the circadian regulatory network
Bhargava, A., Herzel, H., & Ananthasubramaniam, B. (2015) · BMC Systems Biology · doi:10.1186/s12918-015-0227-2 · Cited by 12 · see citing works
Helvacı, N., Oğuz, S. H., Kabaçam, S., Karabulut, E., Akbıyık, F., Alikaşifoğlu, M., & Gürlek, A. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1642909 · Cited by 11 · see citing works
The social evolution of sleep: sex differences, intragenomic conflicts and clinical pathologies
Faria, G. S., Varela, S. A. M., & Gardner, A. (2019) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2018.2188 · Cited by 9 · see citing works
Forced internal desynchrony induces cardiometabolic alterations in adult rats
de Oliveira, I. G. B., Ferreira-Junior, M. D., Lopes, P. R., Campos, D. B. T., Neto, M. L. F., Santos, E. H. R., Mathias, P. C. D. F., Francisco, F. A., Koike, B. D. V., Castro, C. H., et al. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0026 · Cited by 9 · see citing works
Spick, M. P., Isherwood, C., Gethings, L. A., Hughes, C. J., Daly, M. E., Hassanin, H., van der Veen, D. R., Skene, D. J., & Johnston, J. D. (2025) · npj Biological Timing and Sleep · doi:10.1038/s44323-024-00020-2 · Cited by 7 · see citing works
Self-citationZheng, N., Yin, F., Yu, Q., Zhong, J., Yang, J., Xu, Z.-F., Su, J., & Chen, X. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23713 · Cited by 6 · see citing works
Effect of chrono-nutrition–based dietary intervention on metabolic disease
Chen, Y. (2024) · Precision Nutrition · doi:10.1097/pn9.0000000000000076 · Cited by 5 · see citing works
Analysis of the circadian rhythm of biological processes in mouse liver and kidney
Podkolodnyy, N. L., Tverdokhleb, N. N., & Podkolodnaya, O. A. (2017) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vj17.311 · Cited by 2 · see citing works
Genetics and Genomics of Circadian Clocks
Vitaterna, M. H., Turek, F. W., & Jiang, P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00027-1 · Cited by 2 · see citing works
Hou, Z.-G., Xing, M.-C., Zhang, L.-H., Xu, Y., Zhao, X., Gao, X., Zhao, C.-L., & Wu, C. (2025) · Aquaculture International · doi:10.1007/s10499-025-02190-7 · Cited by 1 · see citing works
CCorGsDB: a database for clock correlated genes in the mouse and human central nervous systems
Santos, J. L. A., Pinto, V. T. B. C., Santos, T. E. D. S., Coimbra, D. G., & de Andrade, T. G. (2026) · npj Biological Timing and Sleep · doi:10.1038/s44323-025-00064-y · Cited by 1 · see citing works
Research Progress on Related Genes of Clopidogrel Resistance
李, 倩. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.133549 · Cited by 1 · see citing works
O Papel da crononutrição nas desordens do metabolismo: uma revisão de literatura
Costa, C. G. A. D. C., Soares, P. O., & de Almeida, S. G. (2023) · Research Society and Development · doi:10.33448/rsd-v12i6.42105 · Cited by 6 · see citing works
Yin, D., Zhong, Z., Zeng, F., Xu, Z., Li, J., Ren, W., Yang, G. Y., Wang, H., & Xu, S. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011598 · Cited by 1 · see citing works
Circadian Biology: Interaction with Metabolism and Nutrition
Johnston, J. D. (2016) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789813143319_0005
Self-citationDetection and analysis of dynamic patterns of diurnal expression of mammalian genes
Podkolodnaya, O. V., Tverdokhleb, N. N., & Podkolodnyy, N. L. (2019) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vj18.450
Möller-Levet, C., Laing, E., Archer, S., & Dijk, D. (2021) · bioRxiv · doi:10.1101/2021.08.13.456271
Self-citationSpick, M. P., Isherwood, C., Gethings, L. A., Hassanin, H., van der Veen, D. R., Skene, D. J., & Johnston, J. D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.28.601121
Self-citationMöller‐Levet, C. S., Laing, E., Archer, S. N., & Dijk, D.-J. (2022) · Figshare · doi:10.6084/m9.figshare.19335926
Self-citation
- Authors
- Laing, E. E., Johnston, J. D., Möller‐Levet, C. S., Bucca, G., Smith, C. P., Dijk, D., & Archer, S. N.
- Affiliations
- University of Surrey (GB)
- Corresponding author
- Archer, Simon N.
- ORCID
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2015-03-14
- Volume
- 37
- Issue
- 5
- Pages
- 544-556
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- PMC
- PMC5031210
- OpenAlex
- W2018297674
- Cited by
- 37
- References
- 63
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 2
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- BioEssays (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Brighton Repository (University of Brighton) (publishedVersion, cc-by)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/F022883)
- US Air Force Office of Scientific Research (FA9550-08-1-0080)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian rhythm, circadian genes, NR1D1, NR1D2, rhythmic gene expression, sleep-wake cycle, sleep disruption, glucocorticoid signaling, lipid metabolism, immune function, transcription and translation, diabetes mellitus, cancer, comparative transcriptomics
- MeSH terms
- Animals, Circadian Rhythm, Humans, Nuclear Proteins, Sleep, Mice, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
