The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Is H3K4me3 instructive for transcription activation?
Abstract
Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin modification at the transcription start site of active genes in eukaryotes from yeast to man and its levels reflect the amount of transcription. Because of this association, H3K4me3 is often described as an ‘activating’ histone modification and assumed to have an instructive role in the transcription of genes, but the field is lacking a conserved mechanism to support this view. The overwhelming finding from genome‐wide studies is that actually very little transcription changes upon removal of most H3K4me3 under steady‐state or dynamically changing conditions, including at mammalian CpG island promoters. Instead, rather than a major role in instructing transcription, time‐resolved experiments provide more evidence supporting the deposition of H3K4me3 into chromatin as a result of transcription, influencing processes such as memory of previous states, transcriptional consistency between cells in a population and transcription termination.
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Cites
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H3K4me3 breadth is linked to cell identity and transcriptional consistency
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H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation
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H3K4me3 regulates RNA polymerase II promoter-proximal pause-release
Wang, H., Fan, Z., Shliaha, P. V., Miele, M., Hendrickson, R. C., Jiang, X., & Helin, K. (2023) · Nature · doi:10.1038/s41586-023-05780-8 · Cited by 422
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Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319
Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis
Gheorghe, C. E., Martin, J. A., Manriquez, F. V., Dinan, T. G., Cryan, J. F., & Clarke, G. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.08.004 · Cited by 212
Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation
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Metadata
- Authors
- Howe, F. S., Fischl, H., Murray, S. C., & Mellor, J.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2016-11-07
- Volume
- 39
- Issue
- 1
- Pages
- 1-12
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2551929191
- Cited by
- 513
- References
- 13
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
