Antioxidative activity and ameliorative effects of memory impairment of sulfur-containing compounds in Allium species
Abstract
The antioxidative activity and ameliorative effects on memory impairment by sulfur-containing compounds which occur in Allium vegetables such as onion and garlic were investigated. The antioxidative activities of S-alk(en)yl-L-cysteines and their sulfoxides, volatile alk(en)yl disulfides and trisulfides, and vinyldithiins were examined by using human low-density lipoprotein. It was elucidated that the alk(en)yl substituents and the number of sulfur atoms in the compounds were important for the antioxidative activities. To demonstrate the ameliorative effects on memory impairment, onion extract and synthesized di-n-propyl trisulfide were administered to senescence-accelerated mouse P8. The behavioral experiments showed that onion extract and di-n-propyl trisulfide had highly ameliorative effect of memory impairment. Furthermore, it was found that the hippocampus lipid hydroperoxide in senescence-accelerated mouse P8 was decreased by the administration of di-n-propyl trisulfide. These results suggest that di-n-propyl trisulfide contained in onion ameliorates memory impairment in SAMP8 mouse by its antioxidant effect.
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SAMP8 mice fed for 2 months with a diet containing 2% aged garlic extract (AGE) show improved lifespan and learning scores compared to untreated counterparts.
“Concerning aging, SAMP8 mice fed for 2 months with a diet containing 2% of aged garlic extract (AGE), which has been reported to have a higher antioxidant activity compared to fresh garlic extract [204], show improved lifespan and learning scores compared to the untreated counterpart [205,206,207].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [207]
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- Authors
- Nishimura, H., Higuchi, O., Tateshita, K., Tomobe, K., Okuma, Y., & Nomura, Y.
- Affiliations
- Tokai University (JP)
- Hokkaido University (JP)
- Corresponding author
- Nishimura, Hiroyuki
- ORCID
- Nomura, Yasuyuki
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 2006
- Volume
- 26
- Issue
- 2
- Pages
- 135-146
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W2065483578
- Cited by
- 47
- References
- 56
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 4 · 2013: 2 · 2012: 2
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BioFactors (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hokkaido University
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Keywords
- sulfur compounds, Allium vegetables, onion, garlic, memory impairment, antioxidant activity, LDL oxidation, SAMP8 mice, neuroprotection
- MeSH terms
- Aging, Allium, Animals, Antioxidants, Cysteine, Disulfides, Hippocampus, Humans, Lipid Peroxides, Lipoproteins, LDL, Male, Memory, Phosphatidylcholines, Plant Extracts, Sulfides, Maze Learning, Onions, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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