Improvement of Learning and Memory in Senescence-Accelerated Mice by S-Allylcysteine in Mature Garlic Extract
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S-allylcysteine (SAC), a major thioallyl compound contained in mature garlic extract (MGE), is known to be a neuroactive compound. This study was designed to investigate the effects of SAC on primary cultured hippocampal neurons and cognitively impaired senescence-accelerated mice prone 10 (SAMP10). Treatment of these neurons with MGE or SAC significantly increased the total neurite length and number of dendrites. SAMP10 mice fed MGE or SAC showed a significant improvement in memory dysfunction in pharmacological behavioral analyses. The decrease of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, N-methyl-d-aspartate (NMDA) receptor, and phosphorylated α-calcium/calmodulin-dependent protein kinase II (CaMKII) in the hippocampal tissue of SAMP10 mice fed MGE or SAC was significantly suppressed, especially in the MGE-fed group. These findings suggest that SAC positively contributes to learning and memory formation, having a beneficial effect on brain function. In addition, multiple components (aside from SAC) contained in MGE could be useful for improving cognitive function by acting as neurotrophic factors.
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In primary hippocampal neurons derived from SAMP10 mice, treatment with S-allylcysteine increases dendrite length and number.
“The improvement in memory functions was then confirmed in vitro by a study conducted on primary hippocampal neurons derived from SAMP10 mice, whose dendrites are increased in length and number upon treatment with S-allylcysteine, the most abundant organosulphur compounds present in AGE [208].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [208]
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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
- Authors
- Hashimoto, M., Nakai, T., Masutani, T., Unno, K., & Akao, Y.
- Affiliations
- Ichimaru Pharcos (Japan) (JP)
- Shizuoka University (JP)
- Gifu University (JP)
- Corresponding author
- Akao, Yukihiro
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-06-19
- Volume
- 12
- Issue
- 6
- Pages
- 1834
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC7353456
- OpenAlex
- W3036020773
- Cited by
- 15
- References
- 69
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (20H01037)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- S-allylcysteine, learning and memory, hippocampal neurons, neurite length, AMPA receptors, NMDA receptor, CaMKII phosphorylation, neurotrophic factors, cognitive impairment
- MeSH terms
- Aging, Animals, Cells, Cultured, Cysteine, Disease Models, Animal, Garlic, Hippocampus, Male, Memory, Mice, Inbred C57BL, Plant Extracts, Maze Learning, Mice, Cognitive Dysfunction
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