SAMP8 Mice as a Model of Age-Related Cognition Decline with Underlying Mechanisms in Alzheimer’s Disease

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Regulation of Oxidative Stress by the Anti-aging Hormone Klotho*♦

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Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

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β-Amyloid precursor polypeptide in SAMP8 mice affects learning and memory

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Autophagy and the Cell Cycle: A Complex Landscape

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The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer's disease

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From Aging to Alzheimer's Disease: Unveiling “The Switch” with the Senescence-Accelerated Mouse Model (SAMP8)

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Abnormal gut microbiota composition contributes to cognitive dysfunction in SAMP8 mice

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Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer’s Disease

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Activation of SIRT1 Attenuates Klotho Deficiency–Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity

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Klotho, stem cells, and aging

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Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model

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Animal Models of Alzheimer's Disease: Therapeutic Implications

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The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model

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Coping Strategies among Caregivers of People with Alzheimer Disease: A Systematic Review

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Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease

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A review of endoplasmic reticulum (ER) stress and nanoparticle (NP) exposure

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Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

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(−)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer׳s disease model mice by upregulating neprilysin expression

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A Review of the Brain-Gut-Microbiome Axis and the Potential Role of Microbiota in Alzheimer’s Disease

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An NMDA Receptor Signaling Complex with Protein Phosphatase 2A

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ROS-Induced Activation of DNA Damage Responses Drives Senescence-Like State in Postmitotic Cochlear Cells: Implication for Hearing Preservation

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Part-Time α-Secretases: The Functional Biology of ADAM 9, 10 and 17

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Long-term intake of fish oil increases oxidative stress and decreases lifespan in senescence-accelerated mice

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MicroRNA-200a-3p Mediates Neuroprotection in Alzheimer-Related Deficits and Attenuates Amyloid-Beta Overproduction and Tau Hyperphosphorylation via Coregulating BACE1 and PRKACB

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Changes in oxidative stress parameters and neurodegeneration markers in the brain of the senescence-accelerated mice SAMP-8

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Neurochemistry, Neuropathology, and Heredity in SAMP8: A Mouse Model of Senescence

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Aging and the UPR(ER)

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Effect of Antioxidant-Enriched Diets on Glutathione Redox Status in Tissue Homogenates and Mitochondria of the Senescence-Accelerated Mouse

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Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer’s Disease

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MiR-214-3p attenuates cognition defects via the inhibition of autophagy in SAMP8 mouse model of sporadic Alzheimer's disease

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Age-related autophagy alterations in the brain of senescence accelerated mouse prone 8 (SAMP8) mice

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Dementia in China (2015–2050) estimated using the 1% population sampling survey in 2015

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Melatonin reduces membrane rigidity and oxidative damage in the brain of SAMP8 mice

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Lentivirus-mediated klotho up-regulation improves aging-related memory deficits and oxidative stress in senescence-accelerated mouse prone-8 mice

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Protective effect of resveratrol against inflammation, oxidative stress and apoptosis in pancreas of aged SAMP8 mice

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CDK5: Key Regulator of Apoptosis and Cell Survival

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Klotho, stem cells, and aging

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Propranolol restores cognitive deficits and improves amyloid and Tau pathologies in a senescence-accelerated mouse model

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Dendrobium polysaccharides attenuate cognitive impairment in senescence-accelerated mouse prone 8 mice via modulation of microglial activation

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Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model

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Frontal Cortex Epigenetic Dysregulation During the Progression of Alzheimer’s Disease

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Effects of Baicalein on Cortical Proinflammatory Cytokines and the Intestinal Microbiome in Senescence Accelerated Mouse Prone 8

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The antioxidant curcumin postpones ovarian aging in young and middle-aged mice

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The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging

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Lithium Treatment Decreases Activities of Tau Kinases in a Murine Model of Senescence

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The Effects of LW-AFC on Intestinal Microbiome in Senescence-Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer’s Disease

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The Japanese diet from 1975 delays senescence and prolongs life span in SAMP8 mice

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Learning behaviour and cerebral protein kinase C, antioxidant status, lipid composition in senescence-accelerated mouse: influence of a phosphatidylcholine–vitamin B12diet

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Pseudoginsenoside-F11 alleviates cognitive deficits and Alzheimer’s disease-type pathologies in SAMP8 mice

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Hippocampal neuron loss is correlated with cognitive deficits in SAMP8 mice

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Antioxidative activity and ameliorative effects of memory impairment of sulfur-containing compounds in<i>Allium</i>species

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Early onset of behavioral alterations in senescence-accelerated mouse prone 8 (SAMP8)

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Neuroprotective role of intermittent fasting in senescence-accelerated mice P8 (SAMP8)

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Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: A proteomics study

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N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model

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Klotho at the Edge of Alzheimer’s Disease and Senile Depression

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Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse

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Increase in Presenilin 1 (PS1) levels in senescence-accelerated mice(SAMP8) may indirectly impair memory by affecting amyloid precursor protein(APP) processing

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Icariin Delays Brain Aging in Senescence-Accelerated Mouse Prone 8 (SAMP8) Model via Inhibiting Autophagy

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Lesions and Dysfunctions of the Nucleus Basalis as Alzheimers Disease Models: General and Critical Overview and Analysis of the Long-Term Changes in Several Excitotoxic Models

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Protective Role of Electroacupuncture Against Cognitive Impairment in Neurological Diseases

Xin, Y., Zhou, S., Chu, T., Zhou, Y., & Xu, A. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22999240209102116 · Cited by 17 · see citing works

Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory tolerance

Zhang, N., Zhang, R., Jiang, L., Gao, Z., Xia, W., Ma, X., Qin, Y., Zhang, D., Li, J., Tian, P., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2314337121 · Cited by 17 · see citing works

Investigating gut alterations in Alzheimer’s disease: In-depth analysis with micro- and nano-3D X-ray phase contrast tomography

Palermo, F., Marrocco, N., Dacomo, L., Grisafi, E., Moresi, V., Sanna, A., Massimi, L., Musella, M., Maugeri, L., Bukreeva, I., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr8511 · Cited by 17 · see citing works

Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta

Akbor, M. M., Kurosawa, N., Nakayama, H., Nakatani, A., Tomobe, K., Chiba, Y., Ueno, M., Tanaka, M., Nomura, Y., & Isobe, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248027 · Cited by 17 · see citing works

Stem cells from human exfoliated deciduous teeth relieves Alzheimer’s disease symptoms in SAMP8 mice by up-regulating the PPARγ pathway

Zhang, X., Lei, T., Wang, D., Cai, S., Hang, Z., Yang, Y., Bi, W., Xiao, Z., & Du, H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113169 · Cited by 16 · see citing works

Transcriptomic and metabolomic changes might predict frailty in SAMP8 mice

Dacomo, L., Vitola, P. L., Brunelli, L., Messa, L., Micotti, E., Artioli, L., Sinopoli, E., Cecutti, G., Leva, S., Gagliardi, S., et al. (2024) · Aging Cell · doi:10.1111/acel.14263 · Cited by 15 · see citing works

Neuroprotective Effects of Resveratrol by Modifying Cholesterol Metabolism and Aβ Processing in SAMP8 Mice

Sánchez-Melgar, A., Izquierdo-Ramírez, P. J., Griñán‐Ferré, C., Pallàs, M., Martı́n, M., & Albasanz, J. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147580 · Cited by 16 · see citing works

Cannabinol (CBN) alleviates age-related cognitive decline by improving synaptic and mitochondrial health

Dar, N. J., Currais, A. J. M., Taguchi, T., Andrews, N., & Maher, P. A. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103692 · Cited by 14 · see citing works

Myricetin improves cognitive function in SAMP8 mice and upregulates brain-derived neurotrophic factor and nerve growth factor

Shimada, Y., Sato, Y., Kumazoe, M., Kitamura, R., Fujimura, Y., & Tachibana, H. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.05.039 · Cited by 13 · see citing works

A candidate gene of Alzheimer diseases was mutated in senescence-accelerated mouse prone (SAMP) 8 mice

Akbor, M. M., Kim, J., Nomura, M., Sugioka, J., Kurosawa, N., & Isobe, M. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.07.095 · Cited by 13 · see citing works

Mammalian Models in Alzheimer’s Research: An Update

Sharma, H., Chang, K., Hulme, J., & An, S. S. A. (2023) · Cells · doi:10.3390/cells12202459 · Cited by 11 · see citing works

Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption

Unno, K., Taguchi, K., Takagi, Y., Hase, T., Meguro, S., & Nakamura, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076278 · Cited by 12 · see citing works

Peripheral Administration of the Kv1.3-Blocking Peptide HsTX1[R14A] Improves Cognitive Performance in Senescence Accelerated SAMP8 Mice

Pan, Y., Kagawa, Y., Sun, J., Lucas, D. D., Takechi, R., Mamo, J. C. L., Wai, D. C. C., Norton, R. S., Jin, L., & Nicolazzo, J. A. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01387-z · Cited by 12 · see citing works

Astragalin alleviates cognitive deficits and neuronal damage in SAMP8 mice through upregulating estrogen receptor expression

Liu, H., Zhong, L., Dai, Q., Zhang, Y., & Yang, J. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01045-x · Cited by 11 · see citing works

Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

Bellver‐Sanchís, A., Ávila-López, P. A., Tic, I., Valle‐García, D., Ribalta‐Vilella, M., Labrador, L., Banerjee, D. R., Guerrero, A., Casadesús, G., Poulard, C., et al. (2024) · Neural Regeneration Research · doi:10.4103/1673-5374.393102 · Cited by 11 · see citing works

PRG ameliorates cognitive impairment in Alzheimer's disease mice by regulating β-amyloid and targeting the ERK pathway

Zhang, Z., Wu, H., Wang, S., Li, Y., Yang, P., Xu, L., Liu, Y., & Liu, M. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155671 · Cited by 11 · see citing works

Radix Hedysari Polysaccharides modulate the gut-brain axis and improve cognitive impairment in SAMP8 mice

Yang, S., Wang, L., Liang, X., Pei, T., Zeng, Y., Xie, B., Wang, Y., Yang, M., Wei, D., & Cheng, W. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141715 · Cited by 11 · see citing works

Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis

Lei, L., Cheng, Y., Yin, A., Han, J.-M., Wu, G., Yang, F., Wang, Q., Wang, J., Liu, R., Li, H., et al. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00487-4 · Cited by 13 · see citing works

Proteomic analysis of anti-aging effects of Dendrobium nobile Lindl. alkaloids in aging-accelerated SAMP8 mice

Liu, B., Lv, L.-L., Liu, P., Xu, Y., Guo, M., Liu, J., & Jing-shan, S. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112198 · Cited by 11 · see citing works

Mechanisms underlying LncRNA SNHG1 regulation of Alzheimer’s disease involve DNA methylation

Chen, H., Zhang, C.-J., Zhao, Z.-Y., Gao, Y., Zhao, J.-T., Li, X., Zhang, M., & Wang, H. (2024) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2024.2334248 · Cited by 10 · see citing works

Efficacy and Safety of Natural Apigenin Treatment for Alzheimer's Disease: Focus on In vivo Research Advancements

Zhang, N., Nao, J., & Dong, X. (2024) · Current Neuropharmacology · doi:10.2174/1570159x23666241211095018 · Cited by 11 · see citing works

The Effects of Matcha and Decaffeinated Matcha on Learning, Memory and Proteomics of Hippocampus in Senescence-Accelerated (SAMP8) Mice

Igarashi, K., Takagi, M., & Fukushima, Y. (2022) · Nutrients · doi:10.3390/nu14061197 · Cited by 12 · see citing works

Cholinergic neurodegeneration and cholesterol metabolism dysregulation by constitutive p75NTR signaling in the p75exonIII-KO mice

Baro, R. C., Benito-Martínez, A., Escribano-Saiz, J. J., Franco, M. L., Ceccarelli, L., Calatayud-Baselga, I., Mira, H., & Vilar, M. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1237458 · Cited by 10 · see citing works

Cannabidiol improves the cognitive function of SAMP8 AD model mice involving the microbiota-gut-brain axis

Ma, B.-Q., Jia, J., Wang, H., Li, S., Yang, Z.-J., Wang, X., & Yan, X.-S. (2024) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2024.2338914 · Cited by 10 · see citing works

Yishen Huazhuo decoction regulates microglial polarization to reduce Alzheimer's disease-related neuroinflammation through TREM2

Wang, K., Zan, S., Xu, J., Sun, W., Li, C., Zhang, W., Ni, D., Cheng, R., Li, L., Yu, Z., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35800 · Cited by 9 · see citing works

Targeting farnesoid X receptor as aging intervention therapy

Zhang, L.-J., Yu, J., Gao, X., Yan, Y., Wang, X.-Y., Shi, H., Fang, M., Liu, Y., Kim, Y.-B., Zhu, H., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.01.006 · Cited by 8 · see citing works

Qiangji decoction mitigates neuronal damage, synaptic and mitochondrial dysfunction in SAMP8 mice through the regulation of ROCK2/Drp1-mediated mitochondrial dynamics

Lai, B., Wu, D., Xiao, Q., Wang, Z., Niu, Q., Chen, Q., Long, Q., & He, L. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119424 · Cited by 9 · see citing works

Exogenous Nucleotides Improve the Skin Aging of SAMP8 Mice by Modulating Autophagy through MAPKs and AMPK Pathways

Fan, R., Zhang, Y., Liu, R., Wei, C., Wang, X., Wu, X., Yu, X., Li, Z., Mao, R., Hu, J., et al. (2024) · Nutrients · doi:10.3390/nu16121907 · Cited by 8 · see citing works

Changes in Gene Expression Profile with Age in SAMP8: Identifying Transcripts Involved in Cognitive Decline and Sporadic Alzheimer’s Disease

Griñán‐Ferré, C., Servín-Muñoz, I. V., Palomera‐Ávalos, V., Martínez-Fernández, C., Companys‐Alemany, J., Muñoz-Villanova, A., Ortuño‐Sahagún, D., Pallàs, M., & Bellver‐Sanchís, A. (2024) · Genes · doi:10.3390/genes15111411 · Cited by 8 · see citing works

Effects of the therapeutic correction of U1 snRNP complex on Alzheimer’s disease

Leal, C. B. Q. S., Zimmer, C. G. M., Sinatti, V. V. C., Soares, E. S., Poppe, B., de Wiart, A. C., Chua, X. Y., da Silva, R. V., Magdesian, M. H., Rafii, M. S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-81687-2 · Cited by 8 · see citing works

Examining the effects of extremely low-frequency magnetic fields on cognitive functions and functional brain markers in aged mice

Hadžibegović, S., Nicole, O., Andelkovic, V., de Gannes, F. P., Hurtier, A., Lagroye, I., & Bontempi, B. (2025) · Scientific Reports · doi:10.1038/s41598-025-93230-y · Cited by 8 · see citing works

Bazi Bushen capsule modulates Akkermansia muciniphila and spermidine metabolism to attenuate brain aging in SAMP8 mice

Zhang, S., Mao, X., Chang, L., Li, M., Wei, C., Li, H., Shen, X., Niu, K., Zhang, R., Jiang, Y., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119944 · Cited by 8 · see citing works

Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairments

Ling, L., Guo, Q., Cheng, Y., Gui, Y., Li, W., Zhao, Y., Xu, Z., Luo, Y., Wu, G., Wang, J., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.06.033 · Cited by 9 · see citing works

Akkermansia muciniphila Alleviates Sarcopenia in Senescence-Accelerated Mouse-Prone 8 Mice

Park, S., Kim, H. S., Choi, P. G., Jeong, M. S., Huh, Y. H., Ahn, J., & Jung, C. H. (2025) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2507.07001 · Cited by 8 · see citing works

Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice

Zamorano, M., Alexander, J. F., Catania, D., Dharmaraj, S., Kavelaars, A., & Heijnen, C. J. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00328-w · Cited by 9 · see citing works

Phenotypic Frailty Assessment in SAMP8 Mice: Sex Differences and Potential Role of miRNAs as Peripheral Biomarkers

Musazzi, L., Carini, G., Barbieri, S. S., Maggi, S., Veronese, N., Popoli, M., Barbon, A., & Ieraci, A. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad160 · Cited by 8 · see citing works

Serum metabolomics combined with gut microbiota reveals the effects of Polygala tenuifolia polysaccharide on the metabolic and microbial profiles in SAMP8 mouse

Li, Z., Li, Y., Zhang, J., Liu, Q., Zhu, L., Mao, B., Ma, Y., & Liu, Y. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.116442 · Cited by 7 · see citing works

Neurotrophic Natural Products

Fukuyama, Y., Kubo, M., & Harada, K. (2024) · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products · doi:10.1007/978-3-031-42422-9_1 · Cited by 7 · see citing works

Transcriptome analysis of the aged SAMP8 mouse model of Alzheimer’s disease reveals novel molecular targets of formononetin protection

Liu, B., Cui, D., Liu, J., & Shi, J.-S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1440515 · Cited by 7 · see citing works

Regulation of the NF-κB/NLRP3 signalling pathway by Shenghui Yizhi decoction reduces neuroinflammation in mice with Alzheimer’s disease

Wang, P., Sun, Z., Zhang, G., Jin, Y., Sun, W., Zhao, B., Chen, X., & Li, Q.-B. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2411011 · Cited by 7 · see citing works

Age-related increase in the excitability of mouse layer V pyramidal neurons in the primary motor cortex is accompanied by an increased persistent inward current

Viteri, J. A., Bueschke, N., Santin, J. M., & Arnold, W. D. (2024) · GeroScience · doi:10.1007/s11357-024-01405-8 · Cited by 7 · see citing works

Age-Related Differences in Transient Receptor Potential Vanilloid 1 and 2 Expression Patterns in the Trigeminal Ganglion Neurons Contribute to Changes in the Palatal Mucosal Heat Pain Sensitivity

Oto, T., Urata, K., Hayashi, Y., Hitomi, S., Shibuta, I., Iwata, K., Iinuma, T., & Shinoda, M. (2022) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.2022.j004 · Cited by 7 · see citing works

Age-related Changes in Trigeminal Ganglion Macrophages Enhance Orofacial Ectopic Pain After Inferior Alveolar Nerve Injury

Fujiwara, S., Urata, K., Oto, T., Hayashi, Y., Hitomi, S., Iwata, K., Iinuma, T., & Shinoda, M. (2023) · In Vivo · doi:10.21873/invivo.13062 · Cited by 7 · see citing works

Isotope‐Labeled Chemoselective Probes for Labeling, Separation, and Comprehensive Quantitative Analysis of Sub‐Metabolome

Tian, H., Lai, Z., Zhang, W., Zhang, M., Yang, X., Zhou, J., & Li, Z. (2024) · Small Methods · doi:10.1002/smtd.202400529 · Cited by 6 · see citing works

Gut microbiota and serum metabolomics unveil the role of Phellinus ribis polysaccharides in improving Alzheimer's disease symptoms in senescence-accelerated mice

Zhang, Z., Wang, S., Rong, R., Zhang, G., Li, Z., Li, Y., Wang, R., Liu, Y., & Li, K. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01632-8 · Cited by 6 · see citing works

Tooth loss impairs cognitive function in SAMP8 mice by aggravating pyroptosis of microglia via the cGAS/STING pathway

Sun, X., Lu, Y., Hu, J., Meng, S., Wang, X., & Jiang, Q. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1628520 · Cited by 6 · see citing works

Probiotics Ameliorate Aging-Related Cognitive Impairments and Pathological Changes through Alleviating Telomere Attrition and Enhancing Mitochondrial Function in Senescence-Accelerated Mouse Prone 8 Mice

Zhou, S., Shan, S., Li, R., Wang, X., Xiong, J., & Cheng, G. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c09572 · Cited by 6 · see citing works

Differential Epigenetic Changes in the Dorsal Hippocampus of Male and Female SAMP8 Mice: A Preliminary Study

Ravanelli, F., Musazzi, L., Barbieri, S. S., Rovati, G. E., Popoli, M., Barbon, A., & Ieraci, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713084 · Cited by 6 · see citing works

Xixin Decoction’s novel mechanism for alleviating Alzheimer’s disease cognitive dysfunction by modulating amyloid-β transport across the blood–brain barrier to reduce neuroinflammation

Yang, C., Zhao, E., Zhang, H., Duan, L.-Q., Han, X., Ding, H., Cheng, Y., Wang, D., Lei, X., & Diwu, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1508726 · Cited by 6 · see citing works

Tooth loss impairs cognitive function in SAMP8 mice via the NLRP3 /Caspase‐1 pathway

Sun, X., Lu, Y., Pang, Q., Luo, B., & Jiang, Q. (2023) · Oral Diseases · doi:10.1111/odi.14646 · Cited by 6 · see citing works

Component-specific reduction in perineuronal nets in senescence-accelerated mouse strains

Ueno, H., Takahashi, Y., Murakami, S., Wani, K., Miyazaki, T., Matsumoto, Y., Okamoto, M., & Ishihara, T. (2023) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.01.002 · Cited by 5 · see citing works

Short‐term exercise counteracts accelerated ageing impacts on physical performance and liver health in mice

Pinto, A. P., Muñoz, V. R., Tavares, M. E. A., Neto, I. V. D. S., dos Santos, J. R., Rodrigues, G. S., Carolino, R. O. G., Alberici, L. C., Simabuco, F. M., Teixeira, G. R., et al. (2024) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.70001 · Cited by 4 · see citing works

Neuroprotective effects of G9a inhibition and cannabinoid receptor activation in Alzheimer's disease through a pharmacological approach

Bellver‐Sanchís, A., Ribalta‐Vilella, M., Lillo, J., Ortuño‐Sahagún, D., Franco, R., Pallàs, M., Navarro, G., & Griñán‐Ferré, C. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00616 · Cited by 4 · see citing works

Heterochronic parabiosis alters the transcriptomic landscape to combat aging and aging-related diseases in aging-accelerated mice

Wang, H., Lyu, W., Sun, Y., Jia, X., Bi, J., Wei, R., Du, Z., Meng, F., He, J., Wang, S., et al. (2025) · Life Medicine · doi:10.1093/lifemedi/lnaf025 · Cited by 4 · see citing works

From Aging to Alzheimer's Disease: Unveiling “The Switch” with the Senescence-Accelerated Mouse Model (SAMP8)

Pallàs, M., Camins, A., Smith, M. A., Perry, G. L., Lee, H., & Casadesús, G. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15408 · Cited by 199 · see citing works

Unveiling “The Switch” from Aging to Alzheimer's Disease with the Senescence-Accelerated Mouse Model (SAMP8)

Jaewon, C., Pallàs, M., Zhu, X., Kim, H. J., Camins, A., Lee, H., George, P., Smith, M. A., & Casadesús, G. (2011) · Advances in Alzheimer's disease · doi:10.3233/978-1-60750-733-8-39 · Cited by 1 · see citing works

Progress in Accelerated Senescence Animal Models of SAMP8 Mice for Studying Alzheimer Disease

Xiao-sha, W. (2011) · Medical Recapitulate

Senescence accelerated mouse-prone 8: a model of neuroinflammation and aging with features of sporadic Alzheimer’s disease

Ong, J. Y., Sasaki, K., Ferdousi, F., Suresh, M., Isoda, H., & Szele, F. G. (2025) · Stem Cells · doi:10.1093/stmcls/sxae091 · Cited by 18 · see citing works

The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model

Cheng, X., Zhou, W., & Zhang, Y. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.10.002 · Cited by 133 · see citing works