Polylactic acid: Synthesis and biomedical applications
Abstract
Social and economic development has driven considerable scientific and engineering efforts on the discovery, development and utilization of polymers. Polylactic acid (PLA) is one of the most promising biopolymers as it can be produced from nontoxic renewable feedstock. PLA has emerged as an important polymeric material for biomedical applications on account of its properties such as biocompatibility, biodegradability, mechanical strength and process ability. Lactic acid (LA) can be obtained by fermentation of sugars derived from renewable resources such as corn and sugarcane. PLA is thus an eco-friendly nontoxic polymer with features that permit use in the human body. Although PLA has a wide spectrum of applications, there are certain limitations such as slow degradation rate, hydrophobicity and low impact toughness associated with its use. Blending PLA with other polymers offers convenient options to improve associated properties or to generate novel PLA polymers/blends for target applications. A variety of PLA blends have been explored for various biomedical applications such as drug delivery, implants, sutures and tissue engineering. PLA and their copolymers are becoming widely used in tissue engineering for function restoration of impaired tissues due to their excellent biocompatibility and mechanical properties. The relationship between PLA material properties, manufacturing processes and development of products with desirable characteristics is described in this article…
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In tissue engineering, PLA satisfies the requirements to produce scaffold-based implants, since it is a bioabsorbable polymer that is hydrolytically degradable and does not form hazardous compounds while being broken down.
“In the context of TE, PLA satisfies the requirements to produce scaffold-based implants, since it is a bioabsorbable polymer that is hydrolytically degradable and does not form hazardous compounds while being broken down (Figure 5) [84].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [84]
As the implant bio-resorbs, patients do not need a second surgery to remove it, which lowers healthcare expenses and enables a progressive restoration of tissue function.
“As the implant bio-resorbs, patients do not need a second surgery to remove it, which lowers healthcare expenses and enables a progressive restoration of tissue function [84].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [84]
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The Chemical Recycling of PLA: A Review
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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review
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- Authors
- Singhvi, M. S., Zinjarde, S. S., & Gokhale, D. V.
- Affiliations
- Savitribai Phule Pune University (IN)
- National Chemical Laboratory (IN)
- Corresponding author
- Gokhale, D.V.
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-06-17
- Volume
- 127
- Issue
- 6
- Pages
- 1612-1626
- ISSN
- 1364-5072 (ISSN-L)
- 1365-2672
- OpenAlex
- W2941289539
- Cited by
- 883
- References
- 14
- Citations by year
- 2026: 83 · 2025: 163 · 2024: 148 · 2023: 189 · 2022: 150 · 2021: 101 · 2020: 44 · 2019: 5
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- polylactic acid, lactic acid fermentation, biodegradable polymers, biopolymers, PLA blends, drug delivery, implants, sutures, tissue engineering, biocompatibility, biodegradability, hydrophobicity, impact toughness, renewable raw materials
- MeSH terms
- Biocompatible Materials, Biopolymers, Fermentation, Humans, Polyesters, Drug Delivery Systems, Lactic Acid, Prostheses and Implants, Tissue Engineering, Saccharum
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