Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake
Open accessAbstract
INTRODUCTION: Dopamine (DA) is a neurotransmitter that regulates the rewarding and motivational processes underlying food intake and eating behaviors. This study hypothesized associations of DNA methylation signatures at genes modulating DA signaling with obesity features, metabolic profiles, and dietary intake. METHODS: An adult population within the Methyl Epigenome Network Association project was included (n = 473). DNA methylation levels in white blood cells were measured by microarray (450K). Differentially methylated genes were mapped within the dopaminergic synapse pathway using the KEGG reference database (map04728). Subsequently, network enrichment analyses were run in the pathDIP portal. Associations of methylation patterns with anthropometric markers of general (BMI) and abdominal obesity (waist circumference), the blood metabolic profile, and daily dietary intakes were screened. RESULTS: After applying a correction for multiple comparisons, 12 CpG sites were strongly associated (p < 0.0001) with BMI: cg03489495 (ITPR3), cg22851378 (PPP2R2D), cg04021127 (PPP2R2D), cg22441882 (SLC18A1), cg03045635 (DRD5), cg23341970 (ITPR2), cg13051970 (DDC), cg08943004 (SLC6A3), cg20557710 (CACNA1C), cg24085522 (GNAL), cg16846691 (ITPR2), and cg09691393 (SLC6A3). Moreover, average methylation levels of these genes differed according to the presence or absence of abdominal obesity. Pathway analyses revealed a statistically significant contribution of the aforementioned genes to dopaminergic synapse transmission (p = 4.78E-08). Furthermore, SLC18A1 and SLC6A3 gene methylation signatures correlated with total energy (p < 0.001) and carbohydrate (p < 0.001) intakes. CONCLUSIONS: The results of this investigation reveal that methylation status on DA signaling genes may underlie epigenetic mechanisms contributing to carbohydrate and calorie consumption and fat deposition.
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Methylation status on DA signaling genes (SLC18A1 and SLC6A3) might underlie epigenetic mechanisms contributing to carbohydrate and calorie consumption, as well as fat deposition.
“It has been shown that the methylation status on DA signaling genes (SLC18A1 and SLC6A3) might underlie epigenetic mechanisms contributing to carbohydrate and calorie consumption, as well as fat deposition [157].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [157]
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- Authors
- Ramos‐Lopez, O., Riezu‐Boj, J. I., Milagro, F. I., Martinez, J. A., & MENA Project
- Affiliations
- Department of Nutrition, Food Science and Physiology Center for Nutrition Research University of Navarra Pamplona Spain
- Instituto de Salud Carlos III (ES)
- Venue
- Brain and Behavior
- Publisher
- Wiley
- Published
- 2018-07-11
- Volume
- 8
- Issue
- 8
- Pages
- e01017-e01017
- ISSN
- 2157-9032 (ISSN-L)
- 2162-3279
- PMC
- PMC6085894
- OpenAlex
- W2842849020
- Cited by
- 33
- References
- 78
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 10 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 5 · 2017: 1
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain and Behavior (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, cc-by)
- Funders
- Ministerio de Economía y Competitividad (AGL2013‐45554‐R)
- Consejo Nacional de Ciencia y Tecnología (444175, PNPC 000091)
- Universidad de Navarra (LE/97)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- dopamine signaling, DNA methylation, obesity, abdominal obesity, body mass index, carbohydrate intake, energy intake, dopamine transporter, DRD5, ITPR2, CACNA1C
- MeSH terms
- Adult, Anthropometry, Energy Intake, Dopamine, Eating, Feeding Behavior, Female, Humans, Male, Obesity, Signal Transduction, DNA Methylation, Epigenesis, Genetic, Dopamine Plasma Membrane Transport Proteins, Vesicular Monoamine Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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