Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers
Abstract
Seven healthy subjects underwent two [(11)C]raclopride positron emission tomography (PET) scans, one following a 16-h fast and the other after consumption of a favorite meal (following a 16-h fast) in counterbalanced fashion. Before and after each scan subjects gave ratings of hunger/fullness and desire to eat. In addition, meal pleasantness ratings were collected immediately after consumption of the favorite meal. PET data were analyzed using brain parametric maps to generate regions of statistically significant change, as well as regions of interest manually drawn on each individual's coregistered anatomical image. [(11)C]Raclopride binding potential was compared across the two states (hungry and full). A significant reduction in binding potential was observed in the full compared to the hungry state in the dorsal putamen and caudate nucleus, indicative of dopamine release. There were no changes elsewhere in the striatum. A correlation was observed between the reduction in [(11)C]raclopride binding and meal pleasantness ratings, but not with desire to eat (hunger) or satiety after eating. These results suggest that feeding is associated with dopamine release in the dorsal, but not the ventral striatum, and that the amount of dopamine released correlates with the degree of experienced pleasure.
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Upon exposure to rewarding stimuli, the mesolimbic system releases dopamine into specific target nuclei.
“Upon exposure to rewarding stimuli, the mesolimbic system releases dopamine into specific target nuclei [23,24].”
From Social Media Algorithms and Teen Addiction: Neurophysiological Impact and Ethical Considerations (2025) · cites this paper as [23]
In healthy normal-weight humans, ingestion of palatable food releases DA in the striatum in proportion to ratings of meal pleasantness.
“in healthy, normal-weight human subjects, ingestion of palatable food releases DA in the striatum in proportion to the ratings of meal pleasantness (44)”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [44]
In humans, ingestion of palatable food releases DA in striatum in proportion to meal pleasantness ratings and activates reward circuitry.
“In humans, the ingestion of palatable food releases DA in the striatum in proportion to the ratings of meal pleasantness (42) and activates reward circuitry (43).”
From The Addictive Dimensionality of Obesity (2013) · cites this paper as [42]
In healthy normal weight human subjects, ingestion of palatable food releases DA in the dorsal striatum in proportion to ratings of meal pleasantness.
“Similarly, in healthy normal weight human subjects, the ingestion of palatable food has been shown to release DA in the dorsal striatum in proportion to the ratings of meal pleasantness (Small et al 2003) (Fig. 3).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Small et al 2003
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- Authors
- Small, D. M., Jones-Gotman, M., & Dagher, A.
- Affiliations
- Northwestern University (US)
- Montreal Neurological Institute and Hospital (CA)
- Corresponding author
- Dagher, Alain
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 19
- Issue
- 4
- Pages
- 1709-1715
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1979565994
- Cited by
- 632
- References
- 45
- Citations by year
- 2026: 7 · 2025: 23 · 2024: 20 · 2023: 29 · 2022: 21 · 2021: 38 · 2020: 25 · 2019: 36 · 2018: 39 · 2017: 36 · 2016: 39 · 2015: 47 · 2014: 50 · 2013: 41 · 2012: 42
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McGill University
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- dopamine release, dorsal striatum, feeding, hunger and satiety, desire to eat, caudate nucleus, food reward, ventral striatum
- MeSH terms
- Adult, Brain Mapping, Carbon Radioisotopes, Caudate Nucleus, Corpus Striatum, Dopamine, Eating, Female, Humans, Hunger, Image Processing, Computer-Assisted, Male, Putamen, Satiety Response, Taste, Tomography, Emission-Computed, Raclopride
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