Common Musculoskeletal Tumors of Childhood and Adolescence

Arndt, Carola A.S.; Rose, Peter S.; Folpe, Andrew L.; Laack, Nadia N.

doi:10.1016/j.mayocp.2012.01.015

Cited by 298Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and TreatmentsAcute Lymphoblastic Leukemia research

Common Musculoskeletal Tumors of Childhood and Adolescence

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Arndt, Carola A.S., Rose, Peter S., Folpe, Andrew L., Laack, Nadia N.·2012·Mayo Clinic Proceedings

DOI 10.1016/j.mayocp.2012.01.015PMC PMC3538469

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Abstract

Osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma are the most common malignant musculoskeletal tumors in children and adolescents. Today, most patients can be cured. Numerous factors have contributed to improved outcome for these patients over the past several decades. These include multidisciplinary care involving oncologists, radiation oncologists, surgeons, pathologists, and radiologists and enrollment of patients in clinical trials. Better understanding of molecular mechanisms of disease have resulted in studies using molecular targets in addition to standard chemotherapeutic agents, which hopefully will lead to better outcomes in the future. Moreover, new orthopedic techniques and devices as well as new technologies in radiation oncology hold promise for better local control of primary tumors and the potential for fewer late adverse effects. Despite this progress, patients must undergo lifelong follow-up for possible late effects of intense chemotherapy and radiation therapy. We review the diagnosis, prognosis, staging, multidisciplinary therapy, new directions in therapy, and long-term complications of treatment for these tumors. For this review, we searched MEDLINE using the terms rhabdomyosarcoma, osteosarcoma, Ewing sarcoma, biology, and humans and limited the search to articles from 2000 to September 2011. Additional references found in these articles were utilized as appropriate, as well as references from the background information in current therapeutic studies of the Children's Oncology Group. The same database and time frame were searched for articles written by leading authorities in the field.

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The 5-year survival rate for localized osteosarcoma has plateaued at 60-70% since the introduction of systematic chemotherapy.
“The 5-year survival rate has reached a plateau in osteosarcoma patients with localized disease ranging from 60 to 70% since the introduction of systematic chemotherapy [6].”
From Advances on immunotherapy for osteosarcoma (2024) · cites this paper as [6]

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Self-citation
Defining the Extracellular Matrix of Rhabdomyosarcoma
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Authors: Arndt, C. A. S., Rose, P. S., Folpe, A. L., & Laack, N. N.
Affiliations: Mayo Clinic (US)
Corresponding author: Arndt, Carola A.S.
ORCID: Rose, Peter S.
Folpe, Andrew L.
Laack, Nadia N.
Venue: Mayo Clinic Proceedings
Publisher: Elsevier BV
Published: 2012-05
Volume: 87
Issue: 5
Pages: 475-487
ISSN: 0025-6196 (ISSN-L)
DOI: 10.1016/j.mayocp.2012.01.015
PMC: PMC3538469
OpenAlex: W2168779282
Cited by: 298
References: 184
Citations by year: 2026: 14 · 2025: 15 · 2024: 17 · 2023: 21 · 2022: 22 · 2021: 36 · 2020: 32 · 2019: 11 · 2018: 21 · 2017: 16 · 2016: 22 · 2015: 27 · 2014: 19 · 2013: 22 · 2012: 2
FWCI: 3.81
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Mayo Clinic Proceedings (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
Keywords: osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, childhood cancer, multidisciplinary care, targeted therapy, chemotherapy, radiotherapy, late effects of treatment, long-term follow-up, prognosis, staging, orthopedic reconstruction
MeSH terms: Adolescent, Bone Neoplasms, Child, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Male, Musculoskeletal Diseases, Prognosis, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Soft Tissue Neoplasms

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Common Musculoskeletal Tumors of Childhood and Adolescence

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