The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Real‐time identification of liver cancers by using indocyanine green fluorescent imaging
Abstract
BACKGROUND: We have often encountered difficulties in identifying small liver cancers during surgery. Fluorescent imaging using indocyanine green (ICG) has the potential to detect liver cancers through the visualization of the disordered biliary excretion of ICG in cancer tissues and noncancerous liver tissues compressed by the tumor. METHODS: ICG had been intravenously injected for a routine liver function test in 37 patients with hepatocellular carcinoma (HCC) and 12 patients with metastasis of colorectal carcinoma (CRC) before liver resection. Surgical specimens were investigated using a near‐infrared light camera system. Among the 49 subjects, the 26 patients examined during the latter period of the study (20 with HCC and 6 with metastasis) underwent ICG‐fluorescent imaging of the liver surfaces before resection. RESULTS: ICG‐fluorescent imaging identified all of the microscopically confirmed HCCs (n = 63) and CRC metastases (n = 28) in surgical specimens. Among the 63 HCCs, 8 tumors (13%, including 5 early HCCs) were not evident grossly unless observed by ICG‐fluorescent imaging. Five false‐positive nodules (4 large regenerative nodules and 1 bile duct proliferation) were identified among the fluorescent lesions. Well‐differentiated HCCs appeared as uniformly fluorescing lesions with higher lesion‐to‐liver contrast than that of moderately or poorly differentiated HCCs (162.6 [71.1‐218.2] per pixel vs 67.7 [‐6.3‐211.2] per pixel, P < .001), while CRC metastases were delineated as rim‐fluorescing lesions. Fluorescent microscopy confirmed that fluorescence originated in the cytoplasm and pseudoglands of HCC cells and in the noncancerous liver parenchyma surrounding metastases. ICG‐fluorescent imaging before resection identified 21 of the 41 HCCs (51%) and all of the 16 metastases that were examined. CONCLUSIONS: ICG‐fluorescent imaging enables the highly sensitive identification of small and grossly unidentifiable liver cancers in real time, enhancing the accuracy of liver resection and operative staging. Cancer 2009. © 2009 American Cancer Society.
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Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping
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Terminology of nodular hepatocellular lesions
Wanless, I. R. (1995) · Hepatology · doi:10.1002/hep.1840220341 · Cited by 1,130
INDOCYANINE GREEN: OBSERVATIONS ON ITS PHYSICAL PROPERTIES, PLASMA DECAY, AND HEPATIC EXTRACTION*
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Light-absorbing properties, stability, and spectral stabilization of indocyanine green
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Surgery for small liver cancers
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Self-citationMalignant transformation of adenomatous hyperplasia to hepatocellular carcinoma
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Early Hepatocellular Carcinoma As An Entity With A High Rate of Surgical Cure
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Cited by
Hu, Z., Fang, C., Li, B., Zhang, Z., Cao, C., Cai, M., Su, S., Sun, X., Shi, X., Li, C., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0494-0 · Cited by 1,126
Li, B., Lu, L., Zhao, M., Lei, Z., & Zhang, F. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201801226 · Cited by 658
Intraoperative Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry
Balog, J., Sasi-Szabó, L., Kinross, J., Lewis, M. R., Muirhead, L. J., Veselkov, K., Mirnezami, R., Dezső, B., Damjanovich, L., Darzi, A., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005623 · Cited by 608
van Manen, L., Handgraaf, H. J. M., Diana, M., Dijkstra, J., Ishizawa, T., Vahrmeijer, A. L., & Mieog, J. S. D. (2018) · Journal of Surgical Oncology · doi:10.1002/jso.25105 · Cited by 322
Self-citationRen, T., Wang, Z., Xiang, Z., Lu, P., Lai, H., Yuan, L., Zhang, X., & Tan, W. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202009986 · Cited by 273
Metadata
- Authors
- Ishizawa, T., Fukushima, N., Shibahara, J., Masuda, K., Tamura, S., Aoki, T., Hasegawa, K., Beck, Y., Fukayama, M., & Kokudo, N.
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 2009-05-20
- Volume
- 115
- Issue
- 11
- Pages
- 2491-2504
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- OpenAlex
- W2059931622
- Cited by
- 852
- References
- 16
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- closed
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