An Efficient 1064 nm NIR‐II Excitation Fluorescent Molecular Dye for Deep‐Tissue High‐Resolution Dynamic Bioimaging
Abstract
A small‐molecule fluorophore FD‐1080 with both excitation and emission in the NIR‐II region has been successfully synthesized for in vivo imaging. A heptamethine structure is designed to shift the absorption and emission into NIR‐II region. Sulphonic and cyclohexene groups are introduced to enhance its water solubility and stability. The quantum yield of FD‐1080 is 0.31 %, and can be increased to 5.94 % after combining with fetal bovine serum (FBS). Significantly, 1064 nm NIR‐II excitation was demonstrated with the high tissue penetration depth and superior imaging resolution compared to previously reported NIR excitation from 650 nm to 980 nm. FD‐1080 is not only capable of realizing non‐invasive high‐resolution deep‐tissue hindlimb vasculature and brain vessel bioimaging, but also quantifying the respiratory rate based on the dynamic imaging of respiratory craniocaudal motion of the liver for the awake and anaesthetized mouse.
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Cyanine dyes with varied energy gaps have been designed through structure modifications that allowed the development of fluorophores with emission greater than 1000 nm.
“Cyanine dyes with varied energy gaps have been designed through structure modifications that allowed the development of fluorophores with emission greater than 1000 nm.34−36”
Tail fluorescence emission sometimes allows high-contrast imaging with current organic SWIR fluorophores.
“This tail fluorescence emission sometimes allows high-contrast imaging with current organic SWIR fluorophores.29,34,96,219,220”
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- Authors
- Li, B., Lu, L., Zhao, M., Lei, Z., & Zhang, F.
- Affiliations
- Fudan University (CN)
- Corresponding author
- Zhang, Fan
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2018-03-24
- Volume
- 57
- Issue
- 25
- Pages
- 7483-7487
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2793078295
- Cited by
- 658
- References
- 32
- Citations by year
- 2026: 42 · 2025: 53 · 2024: 67 · 2023: 86 · 2022: 89 · 2021: 95 · 2020: 119 · 2019: 82 · 2018: 24
- FWCI
- 29.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21725502)
- Ministry of Science and Technology of the People's Republic of China (2017YFA0207303)
- Science and Technology Commission of Shanghai Municipality (17JC1400100)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- NIR-II fluorescence, 1064 nm excitation, small-molecule fluorophores, deep tissue imaging, water-soluble dyes, quantum yield enhancement
- MeSH terms
- Animals, Blood Vessels, Fluorescent Dyes, Hindlimb, Mice, Nude, Solubility, Tissue Distribution, Water, Spectroscopy, Near-Infrared, Mice, Molecular Imaging
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