The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
MicroRNA‐205–directed transcriptional activation of tumor suppressor genes in prostate cancer
Open accessAbstract
BACKGROUND: MicroRNAs (miRNAs) are small noncoding RNAs that regulate the expression of approximately 60% of all human genes. They play important roles in numerous cellular processes, including development, proliferation, and apoptosis. Currently, it is believed that miRNAs elicit their effect by silencing the expression of target genes. In this study, the authors demonstrated that miRNA‐205 (miR‐205) induced the expression the interleukin (IL) tumor suppressor genes IL24 and IL32 by targeting specific sites in their promoters. METHODS: The methods used in this study included transfection of small RNAs; quantitative real‐time polymerase chain reaction; in situ hybridization; fluorescence‐labeled in situ hybridization; cell cycle, apoptosis, cell viability, migratory, clonability, and invasion assays; immunoblotting; and luciferase reporter, nuclear run‐on, and chromatin immunoprecipitation assays. RESULTS: The results revealed that miR‐205 was silenced in prostate cancer. Its re‐expression induced apoptosis and cell cycle arrest. It also impaired cell growth, migration, clonability, and invasiveness of prostate cancer cells. Micro‐RNA‐205 induced the expression of tumor suppressor genes IL24 and IL32 at both the messenger RNA and protein levels. The induction of in vitro transcription and enrichment of markers for transcriptionally active promoters in the IL24 and IL32 genes was observed in response to miR‐205. CONCLUSIONS: In this study, a new function for miR‐205 was identified that specifically activated tumor suppressor genes by targeting specific sites in their promoters. These results corroborate a newly identified function that miRNAs have in regulating gene expression at the transcriptional level. The specific activation of tumor suppressor genes (eg, IL24, IL32) or other dysregulated genes by miRNA may contribute to a novel therapeutic approach for the treatment of prostate cancer. Cancer 2010. © 2010 American Cancer Society.
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Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer
Liu, H., Lei, C., He, Q., Pan, Z., Xiao, D., & Tao, Y. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0765-5 · Cited by 336
Tucci, P., Agostini, M., Grespi, F., Markert, E. K., Terrinoni, A., Vousden, K. H., Muller, P. A. J., Dötsch, V., Kehrloesser, S., Sayan, B. S., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110977109 · Cited by 286
Loss of microRNA-205 expression is associated with melanoma progression
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miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages
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Metadata
- Authors
- Majid, S., Dar, A. A., Saini, S., Yamamura, S., Hirata, H., Tanaka, Y., Deng, G., & Dahiya, R.
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 2010-08-24
- Volume
- 116
- Issue
- 24
- Pages
- 5637-5649
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- OpenAlex
- W2088329271
- Cited by
- 294
- References
- 39
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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