Cited by 113Lung Cancer Treatments and MutationsLung Cancer Diagnosis and TreatmentLung Cancer Research Studies

Pemetrexed versus erlotinib in pretreated patients with advanced non-small cell lung cancer: a Hellenic Oncology Research Group (HORG) randomized phase 3 study

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Karampeazis, Athanasios, Voutsina, Alexandra, Souglakos, John, Kentepozidis, Nikos, Giassas, Stelios, Christofillakis, Charalambos, Kotsakis, Athanasios, Papakotoulas, Pavlos +7 more·2013·Cancer

Abstract

BACKGROUND: In this superiority study, pemetrexed was compared with erlotinib in pre-treated patients with metastatic non-small cell lung cancer (NSCLC). METHODS: Patients with stage IIIB/IV NSCLC who progressed after first-line or second-line treatment were randomized to receive either pemetrexed or erlotinib. In total, 21.7% of patients in the pemetrexed arm and 23.5% of patients in the erlotinib arm had squamous cell histology, and treatment was third line in 39.2% and 46.4% of patients, respectively. The primary study endpoint was time to tumor progression (TTP). Epidermal growth factor receptor/v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (EGFR/KRAS) mutation status also was investigated. RESULTS: There was no difference in terms of the TTP (P = .195), the objective response rate (P = .469), or overall survival (P = .986) between the 2 treatment arms. In patients who had squamous cell histology, erlotinib resulted in a superior TTP compared with pemetrexed (4.1 months vs 2.5 months, respectively; P = .006). The incidence of grade 3 and 4 neutropenia, thrombocytopenia, and asthenia was significantly higher in the pemetrexed arm, whereas the incidence of grade 3 and 4 skin rash was higher in the erlotinib arm. CONCLUSIONS: Both pemetrexed and erlotinib had comparable efficacy in pre-treated patients with metastatic NSCLC, and the current results indicated that genotyping of tumor cells may have an important effect on treatment efficacy.

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Crossref · 10.1002/cncr.28132

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Authors
Karampeazis, A., Voutsina, A., Souglakos, J., Kentepozidis, N., Giassas, S., Christofillakis, C., Kotsakis, A., Papakotoulas, P., Rapti, A., Agelidou, M., Agelaki, S., Vamvakas, L., Samonis, G., Mavroudis, D., & Georgoulias, V.
Affiliations
  • NIMTS Hospital (GR)
  • University of Crete (GR)
  • Hellenic Air Force (GR)
  • IASO General Hospital (GR)
  • Department of Medical Oncology 401 Military Hospital of Athens Athens Greece
  • Theageneio General Hospital (GR)
  • Sotiria Chest Diseases Hospital 8th Pulmonary Clinic Athens Greece
  • Sismanoglio General Hospital (GR)
  • University Hospital of Heraklion (GR)
Corresponding author
Georgoulias, Vassilis
Venue
Cancer
Publisher
Wiley
Published
2013-05-09
Volume
119
Issue
15
Pages
2754-2764
ISSN
  • 0008-543X (ISSN-L)
  • 1097-0142
OpenAlex
W1523764380
Cited by
113
References
33
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 9 · 2017: 13 · 2016: 17 · 2015: 25 · 2014: 28 · 2013: 2 · 2012: 1
FWCI
19.50
Type
journal article
Language
en
Open access
Locations
  • Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
Keywords
pemetrexed, erlotinib, non-small cell lung cancer, metastatic non-small cell lung cancer, EGFR mutation, KRAS mutation, lung squamous cell carcinoma, time to tumor progression, third-line therapy, neutropenia, rash, EGFR tyrosine kinase inhibitors, antifolate chemotherapy
MeSH terms
Pemetrexed, Erlotinib Hydrochloride, Adult, Aged, Aged, 80 and over, Antimetabolites, Antineoplastic, Carcinoma, Non-Small-Cell Lung, Female, Folic Acid Antagonists, Glutamates, Guanine, Humans, Lung Neoplasms, Male, Middle Aged, Neoplasm Staging, Quinazolines, Disease Progression, Disease-Free Survival, Protein Kinase Inhibitors

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