Estrogen receptor‐β, but not estrogen receptor‐α, is expressed in prolactin neurons of the female rat paraventricular and supraoptic nuclei: Comparison with other neuropeptides

Suzuki, Shotaro; Handa, Robert J.

doi:10.1002/cne.20457

Cited by 97Neuroendocrine regulation and behaviorEstrogen and related hormone effectsHypothalamic control of reproductive hormones

Estrogen receptor‐β, but not estrogen receptor‐α, is expressed in prolactin neurons of the female rat paraventricular and supraoptic nuclei: Comparison with other neuropeptides

Suzuki, Shotaro, Handa, Robert J.·2005·Journal of Comparative Neurology

DOI 10.1002/cne.20457

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Abstract

Estrogen receptor‐α (ER‐α) and ER‐β exhibit fine differences in their distributions in the rodent forebrain, and one such difference is observed in the paraventricular (PVN) and supraoptic (SON) nuclei. To investigate the functional significance of ER in these brain areas, we examined the neuropeptide characteristics of ER‐expressing neurons in the PVN and SON of female rats by using dual‐label immunocytochemistry. The distributions of ER‐α immunoreactivity (ir) and ER‐β ir were nonoverlapping in the PVN and SON. Nuclear ER‐α ir was found in a population of thyrotropin‐releasing hormone (TRH)‐expressing neurons in the PVN (5.93% ± 1.20% SEM), but not in any other identified cell phenotype of the PVN and SON. The phenotype of neurons with the highest percentage expressing ER‐β was found to be prolactin (PRL) immunoreactive in both the parvocellular (84.95% ± 4.11%) and the magnocellular (84.76% ± 3.40%) parts of the PVN as well as the SON (87.57% ± 4.64%). Similarly, most vasopressin‐immunoreactive neurons were also ER‐β positive in the PVN (66.14% ± 2.47%) and SON (72.42% ± 4.51%). In contrast, although a high percentage of oxytocin (OXY) neurons coexpressed ER‐β in the PVN (84.39% ± 2.99%), there was very little ER‐β/OXY colocalization in the SON. Low levels of corticotropin‐releasing hormone neurons also expressed ER‐β ir in the PVN (12.57% ± 1.99%), but there was no ER‐β colocalization with TRH. In summary, these findings further support the possibility of direct effects of estrogen on neuropeptide expression and implicate estrogen involvement in the regulation of various aspects of neuroendocrine function. J. Comp. Neurol. 484:28–42, 2005. © 2005 Wiley‐Liss, Inc.

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PVN neurons express high levels of estrogen receptor beta (ER-β) and low levels of estrogen receptor alpha (ER-α).
“PVN neurons express high levels of estrogen receptor beta (ER-β) and low levels of estrogen receptor alpha (ER-α) (64–66).”
From Higher Circulating Cortisol in the Follicular vs. Luteal Phase of the Menstrual Cycle: A Meta-Analysis (2020) · cites this paper as [64]

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(1997) · doi:10.1002/(sici)1096-9861(19971201)388:4

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Hypothalamic Control of Prolactin Secretion, and the Multiple Reproductive Functions of Prolactin
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Exogenous estradiol and oxytocin modulate sex differences in hippocampal reactivity during the encoding of episodic memories
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Sex Differences in the Regulation of Vasopressin and Oxytocin Secretion in Bile Duct-Ligated Rats
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Corticotropin-releasing hormone heterogeneous nuclear RNA (hnRNA) and immunoreactivity are induced in extrahypothalamic brain sites by kainic-acid-induced seizures and are modulated by estrogen
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Oestrogen Receptor β is Involved in the Actions of Oestrogens in the Brain for Affective Behaviour, but not Trophic Effects in Peripheral Tissues
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Authors: Suzuki, S., & Handa, R. J.
Affiliations: Loyola University Chicago (US)
Colorado State University (US)
Corresponding author: Handa, Robert J.
ORCID: Suzuki, Shotaro
Handa, Robert J.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 2005-02-16
Volume: 484
Issue: 1
Pages: 28-42
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.20457
OpenAlex: W2054303348
Cited by: 97
References: 96
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 7 · 2013: 6 · 2012: 3
FWCI: 9.38
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (R01AA012693, AA12693)
National Institute of Neurological Disorders and Stroke (R01NS039951, NS39951)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: estrogen receptor beta, estrogen receptor alpha, paraventricular nucleus, supraoptic nucleus, thyrotropin-releasing hormone, vasopressin, oxytocin, corticotropin-releasing factor
MeSH terms: Animals, Arginine Vasopressin, Corticotropin-Releasing Hormone, Female, Immunohistochemistry, Neurons, Neuropeptides, Oxytocin, Paraventricular Hypothalamic Nucleus, Prolactin, RNA, Supraoptic Nucleus, Thyrotropin-Releasing Hormone, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction, Estrogen Receptor alpha, Estrogen Receptor beta, Rats

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Estrogen receptor‐β, but not estrogen receptor‐α, is expressed in prolactin neurons of the female rat paraventricular and supraoptic nuclei: Comparison with other neuropeptides

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