Cited by 90Regulation of Appetite and ObesityEstrogen and related hormone effectsHypothalamic control of reproductive hormones

Oestrogen Modulates Hypothalamic Control of Energy Homeostasis Through Multiple Mechanisms

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Roepke, T. A.·2009·Journal of Neuroendocrinology

Abstract

The control of energy homeostasis in women is correlated with the anorectic effects of oestrogen, which can attenuate body weight gain and reduce food intake in rodent models. This review investigates the multiple signalling pathways and cellular targets that oestrogen utilises to control energy homeostasis in the hypothalamus. Oestrogen affects all of the hypothalamic nuclei that control energy homeostasis. Oestrogen controls the activity of hypothalamic neurones through gene regulation and neuronal excitability. Oestrogen’s primary cellular pathway is the control of gene transcription through the classical oestrogen receptors (ERs) (ERα and ERβ) with ERα having the primary role in energy homeostasis. Oestrogen also controls energy homeostasis through membrane‐mediated events via membrane‐associated ERs or a novel, putative membrane ER that is coupled to G‐proteins. Therefore, oestrogen is coupled to at least two receptors with multiple signalling and transcriptional pathways to mediate immediate and long‐term anorectic effects. Ultimately, it is the interactions of all the receptor‐mediated processes in hypothalamus and other areas of the central nervous system that will determine the anorectic effects of oestrogen and its control of energy homeostasis.

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Crossref · 10.1111/j.1365-2826.2008.01814.x

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  • ERα is abundantly expressed in the rodent brain in VMN, ARC, PVN, and the medial preoptic area; ERβ is found in the same hypothalamic nuclei but at significantly lower expression relative to ERα.

    “While ERα is abundantly expressed in the rodent brain in VMN and ARC, PVN, and the medial preoptic area, ERβ is found in the same hypothalamic nuclei, but ERβ expression is significantly lower relative to ERα [88, 91].”

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Authors
Roepke, T. A.
Affiliations
Oregon Health & Science University (US)
Corresponding author
Roepke, T. A.
Venue
Journal of Neuroendocrinology
Publisher
Wiley
Published
2009-01-15
Volume
21
Issue
2
Pages
141-150
ISSN
  • 0953-8194 (ISSN-L)
  • 1365-2826
OpenAlex
W2139059098
Cited by
90
References
117
Citations by year
2026: 7 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 1 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 11 · 2012: 4
FWCI
0.65
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (1f32dk079508-01)
  • National Institute on Drug Abuse (T32DA007262, 5T32 DA07262)
  • National Institute of Diabetes and Digestive and Kidney Diseases (1F32 DK079508, F32 DK079508)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
estrogen, energy homeostasis, hypothalamus, anorectic effect, oestrogen receptor, estrogen receptor alpha, estrogen receptor beta, gene transcription, neuronal excitability, dietary intake, weight gain, hypothalamic nuclei
MeSH terms
Animals, Body Weight, Energy Metabolism, Estrogens, Female, Gene Expression Regulation, Homeostasis, Humans, Hypothalamus, Neuronal Plasticity, Ovariectomy, Peptides, Receptors, Estrogen, Signal Transduction

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