Oestrogen Modulates Hypothalamic Control of Energy Homeostasis Through Multiple Mechanisms
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The control of energy homeostasis in women is correlated with the anorectic effects of oestrogen, which can attenuate body weight gain and reduce food intake in rodent models. This review investigates the multiple signalling pathways and cellular targets that oestrogen utilises to control energy homeostasis in the hypothalamus. Oestrogen affects all of the hypothalamic nuclei that control energy homeostasis. Oestrogen controls the activity of hypothalamic neurones through gene regulation and neuronal excitability. Oestrogen’s primary cellular pathway is the control of gene transcription through the classical oestrogen receptors (ERs) (ERα and ERβ) with ERα having the primary role in energy homeostasis. Oestrogen also controls energy homeostasis through membrane‐mediated events via membrane‐associated ERs or a novel, putative membrane ER that is coupled to G‐proteins. Therefore, oestrogen is coupled to at least two receptors with multiple signalling and transcriptional pathways to mediate immediate and long‐term anorectic effects. Ultimately, it is the interactions of all the receptor‐mediated processes in hypothalamus and other areas of the central nervous system that will determine the anorectic effects of oestrogen and its control of energy homeostasis.
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ERα is abundantly expressed in the rodent brain in VMN, ARC, PVN, and the medial preoptic area; ERβ is found in the same hypothalamic nuclei but at significantly lower expression relative to ERα.
“While ERα is abundantly expressed in the rodent brain in VMN and ARC, PVN, and the medial preoptic area, ERβ is found in the same hypothalamic nuclei, but ERβ expression is significantly lower relative to ERα [88, 91].”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [91]
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Estrogen deficiency and the origin of obesity during menopause
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Self-citation
- Authors
- Roepke, T. A.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Roepke, T. A.
- ORCID
- Roepke, T. A.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2009-01-15
- Volume
- 21
- Issue
- 2
- Pages
- 141-150
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- PMC
- PMC2679033
- OpenAlex
- W2139059098
- Cited by
- 90
- References
- 117
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 1 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 11 · 2012: 4
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1f32dk079508-01)
- National Institute on Drug Abuse (T32DA007262, 5T32 DA07262)
- National Institute of Diabetes and Digestive and Kidney Diseases (1F32 DK079508, F32 DK079508)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- estrogen, energy homeostasis, hypothalamus, anorectic effect, oestrogen receptor, estrogen receptor alpha, estrogen receptor beta, gene transcription, neuronal excitability, dietary intake, weight gain, hypothalamic nuclei
- MeSH terms
- Animals, Body Weight, Energy Metabolism, Estrogens, Female, Gene Expression Regulation, Homeostasis, Humans, Hypothalamus, Neuronal Plasticity, Ovariectomy, Peptides, Receptors, Estrogen, Signal Transduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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