In search of common developmental and evolutionary origin of the claustrum and subplate
Open accessAbstract
The human claustrum, a major hub of widespread neocortical connections, is a thin, bilateral sheet of gray matter located between the insular cortex and the striatum. The subplate is a largely transient cortical structure that contains some of the earliest generated neurons of the cerebral cortex and has important developmental functions to establish intra‐ and extracortical connections. In human and macaque some subplate cells undergo regulated cell death, but some remain as interstitial white matter cells. In mouse and rat brains a compact layer is formed, Layer 6b, and it remains underneath the cortex, adjacent to the white matter. Whether Layer 6b in rodents is homologous to primate subplate or interstitial white matter cells is still debated. Gene expression patterns, such as those of Nurr1/Nr4a2 , have suggested that the rodent subplate and the persistent subplate cells in Layer 6b and the claustrum might have similar origins. Moreover, the birthdates of the claustrum and Layer 6b are similarly precocious in mice. These observations prompted our speculations on the common developmental and evolutionary origin of the claustrum and the subplate. Here we systematically compare the currently available data on cytoarchitecture, evolutionary origin, gene expression, cell types, birthdates, neurogenesis, lineage and migration, circuit connectivity, and cell death of the neurons that contribute to the claustrum and subplate. Based on their similarities and differences we propose a partially common early evolutionary origin of the cells that become claustrum and subplate, a likely scenario that is shared in these cell populations across all amniotes.
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The correlations between variation in CFM and volume highlight the dorsal thalamus (THA) and three of its components (LAT, TPA, DGT), three amygdalar regions (BLA, LAA, PAN), the hilus of dentate gyrus (DGH), and derivatives of the cortical subplate (CTS) such as the claustrum.
“With respect to memory, the correlations between variation in CFM and volume highlight the dorsal thalamus (THA) and three of its components (LAT, TPA, DGT), but also three amygdalar regions (BLA, LAA, PAN), the hilus of dentate gyrus (DGH), and derivatives of the cortical subplate (CTS) such as the claustrum58.”
From Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice (2026) · cites this paper as [58]
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The Neurotransmitter Receptor Architecture of the Mouse Olfactory System
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The Role of the Claustrum in Parkinson’s Disease and Vascular Parkinsonism: A Matter of Network?
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Claustrum Volumes Are Lower in Schizophrenia and Mediate Patients’ Attentional Deficits
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Proteomic Profiling Reveals Specific Molecular Hallmarks of the Pig Claustrum
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- Authors
- Bruguier, H., Suarez, R., Manger, P., Hoerder‐Suabedissen, A., Shelton, A. M., Oliver, D. K., Packer, A. M., Ferran, J. L., García‐Moreno, F., Puelles, L., & Molnár, Z.
- Affiliations
- University of Oxford (GB)
- Queensland Brain Institute The University of Queensland Brisbane Queensland Australia
- University of the Witwatersrand (ZA)
- Department of Human Anatomy, Medical School University of Murcia and Murcia Arrixaca Institute for Biomedical Research Murcia Spain
- Ikerbasque (ES)
- Universidad de Murcia (ES)
- Corresponding author
- Molnár, Zoltán
- ORCID
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2020-05-06
- Volume
- 528
- Issue
- 17
- Pages
- 2956-2977
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W3014834246
- Cited by
- 84
- References
- 147
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 16 · 2023: 13 · 2022: 9 · 2021: 16 · 2020: 7
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The Journal of Comparative Neurology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Human Frontier Science Program
- Medical Research Council Canada
- Wellcome Trust
- ARC (ARC‐DP160103958, DE160101394)
- Fundación Séneca (19904/GERM/15)
- FEDER (PGC2018‐098229‐B‐100, PGC2018‐096173‐A‐100)
- Ministerio de Ciencia e Innovación
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- claustrum, subplate, cortical development, evolutionary origin, neurogenesis, cell migration, neuronal lineage, programmed cell death, birth date, gene expression, amniotes
- MeSH terms
- Claustrum, Animals, Biological Evolution, Humans, Nerve Net, Neocortex
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