Cited by 462Neurogenesis and neuroplasticity mechanismsNeonatal and fetal brain pathologyFetal and Pediatric Neurological Disorders

The development of the subplate and thalamocortical connections in the human foetal brain

Kostović, Ivica, Judaš, Miloš·2010·Acta Paediatrica

Abstract

The aim of this review is to present clinically relevant data on prenatal development of thalamocortical connections in the human brain. The analysis is based on extensive Zagreb Neuroembryological Collection, including more than 500 prenatal human brains stained with various classical neurohistological, as well as modern histochemical and immunohistochemical methods. The connection of thalamocortical axons during the ‘waiting’ period with transient cortical subplate zone and subsequent synaptic engagement in the cortical plate is the main connectivity event in the late foetus and preterm infant. This connectivity is the structural substrate for the endogeneous subplate and sensory‐driven circuitry generating transient electrical phenomena and may represent a transient network in the developmental history of consciousness. Conclusion: Findings presented in this review should be considered in the management of pain in preterm infants, in searching for the vulnerability of the subplate zone in diagnostic procedures using the in vivo MRI and in revealing the developmental origin of cognitive and mental disorders.

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Crossref · 10.1111/j.1651-2227.2010.01811.x

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75 of 75 references verified0 citation errors · 0 not checkable

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  • SP shows enrichment for mature neuronal markers and synaptic transmission, reflecting early thalamic afferent input by midgestation.

    “SP, which contains the earliest-generated neurons, showed enrichment for mature neuronal markers and synaptic transmission, reflecting early thalamic afferent input by midgestation35.”

    From Transcriptional landscape of the prenatal human brain (2014) · cites this paper as [35]

  • SP is a largely transient zone beneath CP that plays an important role in establishment of thalamocortical connectivity.

    “The SP is a largely transient zone beneath the CP that plays an important role in establishment of thalamocortical connectivity (see35 for review).”

    From Transcriptional landscape of the prenatal human brain (2014) · cites this paper as [35]

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Authors
Kostović, I., & Judaš, M.
Affiliations
University of Zagreb (HR)
Venue
Acta Paediatrica
Publisher
Wiley
Published
2010-07
Volume
99
Issue
8
Pages
1119-1127
ISSN
  • 0365-1436 (ISSN-L)
  • 0803-5253
  • 1651-2227
OpenAlex
W1755908671
Cited by
462
References
75
Citations by year
2026: 22 · 2025: 26 · 2024: 28 · 2023: 24 · 2022: 26 · 2021: 19 · 2020: 68 · 2019: 30 · 2018: 24 · 2017: 25 · 2016: 31 · 2015: 33 · 2014: 36 · 2013: 29 · 2012: 15
FWCI
1.78
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Paediatrica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords
subplate, thalamocortical connections, fetal brain development, cortical plate, preterm infants, pain management, consciousness development
MeSH terms
Afferent Pathways, Axons, Cerebral Cortex, Humans, Infant, Newborn, Infant, Premature, Neural Pathways, Staining and Labeling, Thalamus, Fetal Development

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