Evolution of pallium, hippocampus, and cortical cell types revealed by single-cell transcriptomics in reptiles
Abstract
Evolution of the brain: Just how related are reptilian and mammalian brains? Tosches et al. used single-cell transcriptomics to study turtle, lizard, mouse, and human brain samples. They assessed how the mammalian six-layered cortex might be derived from the reptilian three-layered cortex. Despite a lack of correspondence between layers, mammalian astrocytes and adult neural stem cells shared evolutionary origins. General classes of interneuron types were represented across the evolutionary span, although subtypes were species-specific. Pieces of the much-folded mammalian hippocampus were represented as adjacent fields in the reptile brains. Science , this issue p. 881
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The reptilian cortex contains interneurons that are transcriptionally similar to the major classes of mammalian cortical interneurons.
“the reptilian cortex contains interneurons that exhibit transcriptional similarities with the major classes of cortical interneurons described mammals”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Tosches et al., 2018
There is no evidence for further diversification among GABAergic interneurons in the reptilian cortex.
“there is no evidence for further diversification among GABAergic interneurons in the reptilian cortex”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Tosches et al., 2018
At least the major interneuron types existed in the common ancestor of reptiles and mammals.
“which suggest that at least these types of interneuron existed in the ancestor of reptiles and mammals”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Tosches et al., 2018
New interneuron types in mammals probably arose through diversification of ancestral gene regulatory programs.
“the generation of new types of interneuron in mammals probably arise through the diversification of the ancestral generegulatory programs”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Tosches et al., 2018
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- Authors
- Tosches, M. A., Yamawaki, T. M., Naumann, R. K., Jacobi, A. A., Tushev, G., & Laurent, G.
- Affiliations
- Max Planck Institute for Brain Research (DE)
- Corresponding author
- Tosches, Maria Antonietta
- Yamawaki, Tracy M.
- Laurent, Gilles
- ORCID
- Venue
- Science
- Published
- 2018-05-25
- Volume
- 360
- Issue
- 6391
- Pages
- 881-888
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2801175520
- Semantic Scholar
- f1aa8ef0833383ff12bf092eb6fa0a45228c8050
- Cited by
- 506
- References
- 11
- Citations by year
- 2026: 45 · 2025: 62 · 2024: 69 · 2023: 55 · 2022: 77 · 2021: 80 · 2020: 62 · 2019: 44 · 2018: 12
- FWCI
- 18.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- European Research Council (322705)
- Max Plank Society
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- pallium, hippocampus, cortical cell types, glutamatergic neurons, GABAergic interneurons, reptile brain evolution, gene regulatory programs, gene expression atlas, single-cell transcriptomics
- MeSH terms
- Animals, Biological Evolution, Hippocampus, Neuroglia, Neurons, Reptiles, Neocortex, Gene Expression Profiling, Cell Tracking, Single-Cell Analysis, GABAergic Neurons
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