CoChat
Sign Up
Cited by 3,592Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

Altman, Joseph, Das, Gopal D.·1965·Journal of Comparative Neurology
DOI 10.1002/cne.901240303
Open this paper in CoChat — free account

Abstract

In the autoradiograms of young rats injected with thymidine‐H 3 many of the granule cells of the dentate gyrus were found labeled. The number of labeled cells declined rapidly with increased age at the time of injection. Histological studies showed the presence in young rats of a large germinal matrix of mitotic cells in the ependymal and subependymal layers of the third and lateral ventricles. The areal extent and cell population of this germinal pool declined rapidly from birth on, with a transient rise with a peak at about 15 days. During this latter period the number of “undifferentiated” cells near the granular layer of the dentate gyrus showed a rapid rise with a subsequent decline. The decline in the number of “undifferentiated” cells was accompanied by a rise in the number of differentiated granule cells. Cell counts in homologous parts of the dentate gyrus indicated a six‐fold increase in the number of differentiated granule cells from birth to three months. We postulated that undifferentiated cells migrate postnatally from the forebrain ventricles to the hippocampus where they become differentiated. The possible functional significance of delayed hippocampal neurogenesis is discussed with reference to our finding of incorporation of testosterone‐H 3 by cells of the hippocampus, implicating that they may function as receptors of gonadal hormones.

Overview

Integrity signals

Registry

Crossref · 10.1002/cne.901240303

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 18 references

Research works printed but not linked: 2

  1. Allen E., 1912, The cessation of mitosis in the central nervous system of the albino rat, J. Comp. Neur., 22, 547
  2. Kjellgren K., 1944, Studien über die Entwicklung der Neuronen nach der Geburt, ihre Regeneration und die Asymmetrien ihrer Verteilung beim Menschen, Acta Psychiat. Neurol. Scand., Suppl., 29, 1

Cited by

Sorted by citations

Items 1,001–1,014 of 1,014

Related

See all

Metadata

Authors
Altman, J., & Das, G. D.
Affiliations
Massachusetts Institute of Technology (US)
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1965-06
Volume
124
Issue
3
Pages
319-335
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.901240303
OpenAlex
W1980499453
Cited by
3,592
References
18
Citations by year
2026: 55 · 2025: 79 · 2024: 66 · 2023: 92 · 2022: 112 · 2021: 131 · 2020: 130 · 2019: 136 · 2018: 116 · 2017: 128 · 2016: 132 · 2015: 143 · 2014: 142 · 2013: 145 · 2012: 160
FWCI
6.21
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 14374 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
dentate gyrus granule cells, germinal matrix, ependymal layer, undifferentiated cells, cell migration, rat brain development
MeSH terms
Animals, Animals, Newborn, Autoradiography, Cell Differentiation, Hippocampus, Testosterone, Thymidine, Tritium, Rats, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review