Mild Traumatic Brain Injury Produces Long-Lasting Deficits in Synaptic Plasticity in the Female Juvenile Hippocampus
Abstract
Mild traumatic brain injury (mTBI) is becoming recognized as a significant concern in modern society. In particular, youth is being increasingly seen as a vulnerable time period for mTBI, as this is the final developmental period for the brain and typically involves robust synaptic reorganization and axonal myelination. Another issue that is being hotly debated is whether mTBI differentially impacts the male and female brain. To examine the impact of mTBI in the juvenile brain, we measured hippocampal synaptic plasticity using a closed-head mTBI model in male and female Long–Evans rats (25–28 days of age) at either 1 h, 1 day, 7 days, or 28 days post-injury. In female rats, the dentate gyrus (DG) region ipsilateral to the impact showed a significant reduction in long-term potentiation (LTP) at 1 day, which persisted to 28 days following injury. In male rats, the deficit in LTP was maximal in the CA1 and DG subfields ipsilateral to the impact site 7 days post-injury; however, these deficits did not persist to 28 days post-injury. These data indicate that mTBI can produce more immediate and persistent impairments in synaptic plasticity in the female brain.
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Studies indicate sex-based differences in neuroplasticity.
“Third, are there differences in the brain repair and recovery processes of men and women and in the associated recovery of function? The data also support this premise, with studies indicating sex-based differences in neuroplasticity.”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [16]
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Self-citation
- Authors
- White, E. R., Pinar, C., Bostrom, C. A., Meconi, A., & Christie, B. R.
- Affiliations
- University of Victoria (CA)
- University of British Columbia (CA)
- Corresponding author
- Christie, Brian R.
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2017-03
- Volume
- 34
- Issue
- 5
- Pages
- 1111-1123
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- OpenAlex
- W2553299053
- Cited by
- 49
- References
- 104
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 2 · 2017: 2
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurotrauma (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- mild traumatic brain injury, synaptic plasticity, long-term potentiation, hippocampus, sex differences, juvenile brain, dentate gyrus, CA1, Long-Evans rats, adolescent brain development
- MeSH terms
- Age Factors, Animals, Brain Concussion, Disease Models, Animal, Female, Hippocampus, Male, Long-Term Potentiation, Rats, Long-Evans, Rats
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