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Cited by 104Visual perception and processing mechanismsAxon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Afferent and efferent connections of the striate and extrastriate visual cortex of the normal and reeler mouse

Simmons, Peter A., Lemmon, Vance, Pearlman, Alan L.·1982·Journal of Comparative Neurology
DOI 10.1002/cne.902110308
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Abstract

In order to analyze the role of lamination in establishing the precisely ordered connectional pattern of the neocortex, we compared the afferent and efferent connections of the visual cortical areas in normal mice with those of the mutant mouse reeler (rl). The reeler mutation causes disruption of the laminar organization of the neocortex; all classes of neurons are present but are abnormally located. The corticocortical and thalamocortical connections of visual cortical areas 17, 18a, and 18b were determined in normal and reeler mice with injections of horseradish peroxidase (HRP) or HRP conjugated with wheat germ agglutinin (HRP‐WGA). The diffusion of HRP‐WGA is highly restricted due to the surface binding properties of the lectin; it was particularly effective in demonstrating retinotopically ordered connections. We found that the patterns of connections made by the reeler mutant are indistinguishable from normal. Cortical loci in area 17 are reciprocally connected to homotopic locations in areas 18a and 18b. Area 17 is also reciprocally connected with the dorsal lateral geniculate nucleus of the thalamus and projects to the superior colliculus. Areas 18a and 18b are reciprocally connected with each other and with the lateral posterior and lateral nuclei of the thalamus, respectively. In addition, we found evidence of reciprocal connections between the lateral posterior nucleus and area 17, and between the lateral nucleus and areas 17 and 18a. The results indicate that neurons in visual cortical areas of the reeler mutant mouse are capable of forming retinotopically organized corticocortical and thalamocortical connections in a pattern similar to that found in normal animals. Thus the genetic anomaly producing incorrect neuronal positioning during development of the reeler cortex does not seriously impede the pathway and target recognition mechanisms responsible for formation of functionally appropriate cortical connections.

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  • The visual pathway is composed of primary and associational visual cortical areas (VISp, VISam, VISal/l, and TEa) and thalamic nuclei LGd, LGv, and LP.

    “The visual pathway is composed of primary and associational visual cortical areas (VISp, VISam, VISal/l, and TEa) and thalamic nuclei LGd, LGv, and LP100,103,109”

    From A mesoscale connectome of the mouse brain (2014) · cites this paper as [109]

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Authors
Simmons, P. A., Lemmon, V., & Pearlman, A. L.
Affiliations
Washington University in St. Louis (US)
ORCID
Lemmon, Vance
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1982-11
Volume
211
Issue
3
Pages
295-308
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.902110308
OpenAlex
W2134683835
Cited by
104
References
69
Citations by year
2026: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
3.75
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8013 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders
  • National Institute for Health and Care Research
  • National Institutes of Health (5r01ey000621-27)
  • National Eye Institute
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
reeler mice, extrastriate cortex, corticocortical connections, thalamocortical connections, retinotopic organization, cortical lamination, dorsal lateral geniculate nucleus, lateral posterior thalamic nucleus, superior colliculus, reciprocal connections, cortical development
MeSH terms
Animals, Brain Mapping, Dominance, Cerebral, Female, Geniculate Bodies, Horseradish Peroxidase, Male, Mice, Neurologic Mutants, Models, Neurological, Nerve Fibers, Neurons, Retina, Thalamic Nuclei, Visual Cortex, Visual Pathways, Mice

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