CoChat
Sign Up
Cited by 241Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationFetal and Pediatric Neurological Disorders

The development of the hippocampus and dentate gyrus in normal and reeler mice

Stanfield, Brent B., Cowan, W. Maxwell·1979·Journal of Comparative Neurology
DOI 10.1002/cne.901850303
Open this paper in CoChat — free account

Abstract

The histogenesis, the time of origin and the pattern of migration of the cells in the hippocampus and dentate gyrus, have been studies in normal and reeler mice. The earliest indication of a defect in the reeler hippocampus is seen on the fifteenth embryonic day (E15) which is at least 24 hours after the first indication of a defect in the neocortex. It is not until E18, that the dentate gyrus shows signs of its incipient abnormality. It appears then, in both the hippocampus and the dentate gyrus the gene defect first manifests itself at the stage at which the definitive cellular are assembled. Experiments involving the injection of 3(H‐TdR) at different developmental stages have confirmed that the site and rate of cellular proliferation in the reeler hippocampus and dentate gyrus are normal, as is the initial pattern of cell migration. However, in the reeler dentate gyrus, most postnatal cell proliferation occurs ectopically and in the hippocampus the normal “inside‐out” sequence of neurogenesis is reversed, the earliest pyramidal cells generated coming to lie superficially within the stratum pyramidale and the later formed cells being added at progressively deeper levels. There is no discernible gradient in the time of origin of the granule cells in the radial dimension of the reeler dentate gyrus, whereas there is an obvious “outside‐in” gradient in the normal animal. The characteristic gradients in cell proliferation seen in the transverse and longitudinal dimensions of the normal dentate gyrus are, however, also evident in the reeler mouse. Taken together, these observations suggest that the reeler gene exerts its effect on neuronal position only in the radial dimension, and does so at a stage of development subsequent to the proliferation and initial migration of the relevant neurons. Timm's sulfide silver preparations indicate that the characteristic staining patterns seen in the dentate gyrus and hippocampus appear at the same time, and mature at the same rate in normal and reeler mice.

Integrity signals

Registry

Crossref · 10.1002/cne.901850303

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Cre/loxP recombination that deletes the NMDAR1 gene occurs during the third postnatal week, about 2 weeks after the CA1 region of the hippocampus has completed its cellular organization and connections.

    “an accompanying article (Tsien et al., 1996) in which we use the expression of b -galactosidase as a reporter for the recombination shows that it occurs during the third postnatal week, about 2 weeks after the CA1 region of the hippocampus has completed its cellular organization and connections”

    From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Stanfield and Cowan 1979

  • Dentate granule neurons are born in an outside-out manner during development and adulthood.

    “Both during development and in adulthood, dentate granule neurons are born in an outside-out manner [8, 30]”

    From Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis (2015) · cites this paper as [30]

  • The reeler mouse mutant has neurons generated normally but abnormally placed, resulting in disorganization of cortical laminar layers in the CNS.

    “The reeler is an autosomal recessive mouse mutant, in which neurons are generated normally but are abnormally placed, resulting in disorganization of cortical laminar layers in the CNS (7–12).”

    From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [9]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Stanfield, B. B., & Cowan, W. M.
Affiliations
Washington University in St. Louis (US)
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1979-06
Volume
185
Issue
3
Pages
423-459
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.901850303
OpenAlex
W2016827719
Cited by
241
References
31
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 4 · 2012: 6
FWCI
3.64
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 9262 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords
hippocampus development, dentate gyrus, reeler mice, neuronal migration, cell proliferation, granule cells, pyramidal neurons, radial gradient, embryonic development
MeSH terms
Animals, Autoradiography, Cell Movement, Hippocampus, Mice, Inbred C57BL, Mice, Neurologic Mutants, Mitosis, Morphogenesis, Species Specificity, Staining and Labeling, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review