Laminar distribution of neurotransmitter receptors in different reeler mouse brain regions
Abstract
Mapping of multiple receptors of neurotransmitters provides insight into the spatial distribution of neurotransmission-relevant molecules in the cerebral cortex. During development, lack of reelin leads to impaired migration, disturbed lamination of the hippocampus and inverted neocortical layering. In the adult, reelin may regulate synaptic plasticity by modulating neurotransmitter receptor function. Using quantitative in vitro receptor autoradiography, different receptors, in particular, the binding site densities and laminar distribution of various glutamate, GABA, muscarinic and nicotinic acetylcholine, serotonin, dopamine and adenosine receptors, were analyzed in cortical and subcortical structures of reeler and wild-type brains. Differential changes in the laminar distribution, maximum binding capacity (B (max)) and regional density of neurotransmitter receptors were found in the reeler brain. A decrease of whole brain B (max) was found for adenosine A(1) and GABA(A) receptors. In the forebrain, several binding sites were differentially up- or down-regulated (kainate, A(1), benzodiazepine, 5-HT(1), M(2), α(1) and α(2)). In the hippocampus, a significant decrease of GABA(B), 5-HT(1) and A'₁ receptors were observed. The density of M(2) receptors increased, while other receptors remained unchanged. In the neocortex, some receptors demonstrated an obviously inverted laminar distribution (AMPA, kainate, NMDA, GABA(B), 5-HT(1), M(1), M(3), nAch), while the distribution of others (A(1), GABA(A), benzodiazepine, 5-HT(2), muscarinic M(2), adrenergic α(1), α(2)) seemed to be less affected. Thus, the laminar receptor distribution is modulated by the developmental impairment and suggests and reflects partially the laminar inversion in reeler mice.
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Reeler heterozygous mice with reduced reelin show decreased GAD67 and fewer GABAA and GABAB receptors in whole brain and hippocampus.
“Reeler heterozygous mice, which are haploinsufficient for reelin, exhibit decreased GAD 67 [138] and reduced GABAA and GABAB receptors in the whole brain and hippocampus, respectively [139].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [139]
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Consensus Paper: Pathological Role of the Cerebellum in Autism
Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723 · see citing works
- Authors
- Cremer, C. M., Lübke, J. H. R., Palomero-Gallagher, N., & Zilles, K.
- Affiliations
- Forschungszentrum Jülich (DE)
- Corresponding author
- Lübke, Joachim H. R.
- Venue
- Brain Structure and Function
- Published
- 2011-03-27
- Volume
- 216
- Issue
- 3
- Pages
- 201-218
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- OpenAlex
- W2054797133
- Cited by
- 17
- References
- 71
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2014: 5 · 2012: 1
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- reeler mice, reelin, neurotransmitter receptors, laminar distribution, cerebral cortex, hippocampus, receptor binding density, glutamate receptors, GABA receptors, muscarinic receptors, nicotinic acetylcholine receptors, serotonin receptors, dopamine receptors, adenosine receptors, receptor autoradiography, synaptic plasticity
- MeSH terms
- Reelin Protein, Analysis of Variance, Animals, Autoradiography, Brain, Brain Mapping, Densitometry, Image Processing, Computer-Assisted, Male, Mice, Neurologic Mutants, Nerve Tissue Proteins, Synaptic Transmission, Radioligand Assay, Regression Analysis, Serine Endopeptidases, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Receptors, Neurotransmitter, Mice
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