CoChat
Sign Up
Cited by 191Olfactory and Sensory Function StudiesNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Olfactory projections to the hypothalamus

Price, J. L., Slotnick, B. M., Revial, M.‐F.·1991·Journal of Comparative Neurology
DOI 10.1002/cne.903060309
Open this paper in CoChat — free account

Abstract

Electrophysiological recording, together with anterograde and retrograde axonal tracers, was used to provide a comprehensive description of the origin and distribution of the olfactory input to the lateral hypothalamus. This input was much more substantial to the caudal part of the hypothalamus than to the rostral part and originates from several different areas of the olfactory cortex. Positive responses to electrical stimulation of the olfactory bulb were found consistently in the postero-lateral hypothalamus, but only occasionally at more rostral levels. In agreement with this, injections of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) in the posterior half of the lateral hypothalamus labeled cells in four cortical areas that receive input from the olfactory bulb: the anterior olfactory nucleus, the piriform cortex (in the deepest layer or ventral endopiriform nucleus), the olfactory tubercle (in the deep polymorphic layer), and the anterior cortical nucleus of the amygdala. Injections of WGA-HRP in the anterolateral hypothalamus labeled cells only in the anterior cortical nucleus of the amygdala. Anterograde axonal tracing confirmed these projections. Injections of 3H-leucine in the anterior olfactory nucleus, the piriform cortex, and the olfactory tubercle produced axonal label that was light and confined to the medial forebrain bundle in the rostral hypothalamus but was more substantial and extended throughout the lateral hypothalamic area caudally. Injections in the anterior cortical amygdaloid nucleus labeled axons in the anterior hypothalamus and in the premammillary nuclei as well as in the posterolateral hypothalamic area. In addition, a projection was demonstrated to the nuclei gemini from the polymorphic zone deep to the olfactory tubercle. Injections of two fluorescent retrograde tracers into the mediodorsal nucleus of the thalamus and the posterolateral hypothalamus showed that cells projecting to both diencephalic sites were intermingled in all of the olfactory cortical areas except the anterior olfactory nucleus, where cells were labeled only from the hypothalamus. In the deep layer of the piriform cortex and in the anterior cortical amygdaloid nucleus cells were also double labeled, indicating that they send collateral axons to both parts of the diencephalon.

Integrity signals

Registry

Crossref · 10.1002/cne.903060309

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Price, J. L., Slotnick, B. M., & Revial, M. ‐.
Affiliations
  • Washington University in St. Louis (US)
  • American University (US)
  • Lyon 1 Université (FR)
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1991-04-15
Volume
306
Issue
3
Pages
447-461
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.903060309
OpenAlex
W2164866920
Cited by
191
References
40
Citations by year
2026: 8 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 10 · 2020: 1 · 2019: 6 · 2018: 8 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 7 · 2013: 2 · 2012: 6
FWCI
2.38
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4926 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Deafness and Other Communication Disorders (R01DC000093, R01 DC00093)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
olfactory projections, lateral hypothalamus, olfactory bulb, anterior olfactory nucleus, piriform cortex, olfactory tubercle, medial forebrain bundle, mediodorsal thalamus, diencephalon, axon tracing, retrograde tracing, olfactory cortex
MeSH terms
Amygdala, Animals, Axonal Transport, Brain Mapping, Diencephalon, Electrophysiology, Fluorescent Dyes, Frontal Lobe, Horseradish Peroxidase, Hypothalamus, Olfactory Bulb, Olfactory Pathways, Thalamic Nuclei, Wheat Germ Agglutinins, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review