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The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.

Efferent projections of the infralimbic cortex of the rat

Hurley, Karen M., Herbert, Horst, Moga, Margaret M., Saper, Clifford B.·1991·Journal of Comparative Neurology
DOI 10.1002/cne.903080210
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Abstract

On the basis of stimulation studies, it has been proposed that the infralimbic cortex (ILC), Brodmann area 25, may serve as an autonomic motor cortex. To explore this hypothesis, we have combined anterograde tracing with Phaseolus vulgaris leucoagglutinin (PHA-L) and retrograde tracing with wheat germ aggutinin conjugated to horseradish peroxidase (WGA-HRP) to determine the efferent projections from the ILC. Axons exit the ILC in one of three efferent pathways. The dorsal pathway ascends through layers III and V to innervate the prelimbic and anterior cingulate cortices. The lateral pathway courses through the nucleus accumbens to innervate the insular cortex, the perirhinal cortex, and parts of the piriform cortex. In addition, some fibers from the lateral pathway enter the corticospinal tract. The ventral pathway is by far the largest and innervates the thalamus (including the paraventricular nucleus of the thalamus, the border zone between the paraventricular and medial dorsal nuclei, and the paratenial, reuniens, ventromedial, parafasicular, and subparafasicular nuclei), the hypothalamus (including the lateral hypothalamic and medial preoptic areas, and the suprachiasmatic, dorsomedial, and supramammillary nuclei), the amygdala (including the central, medial, and basomedial nuclei, and the periamygdaloid cortex) and the bed nucleus of the stria terminalis. The ventral efferent pathway also provides descending projections to autonomic cell groups of the brainstem and spinal cord including the periaqueductal gray matter, the parabrachial nucleus, the nucleus of the solitary tract, the dorsal motor vagal nucleus, the nucleus ambiguus, and the ventrolateral medulla, as well as lamina I and the intermediolateral column of the spinal cord. The ILC has extensive projections to central autonomic nuclei that may subserve a role in modulating visceral responses to emotional stimuli, such as stress.

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Citations

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Research works printed but not linked: 9

  1. Allen G. V., 1987, Mamillary, supramamillary and tuberomamillary nuclei: Connections with infralimbic cortex, Neurosci. Abstr., 13, 1166
  2. Ston‐Jones G., 1989, Topographic projections from the periaqueductal gray to the ventrolateral medulla in the rat, Soc. Neurosci. Abstr., 15, 593
  3. Chamberlin N. L., 1990, Physiological anatomy of the parabrachial nucleus of the rat, Soc. Neurosci. Abstr., 16, 555
  4. Cechetto D. F., 1990, Subcortical sites mediate sympathetic responses from insular cortex, Am. J. Physiol., 258, R245
  5. de Olmos J., 1985, The Rat Nervous System: I. Forebrain and Midbrain, 223
  6. Lofving B., 1961, Cardiovascular adjustments induced from the rostral cingulate gyrus, Acta Physiol. Scand. Suppl., 184, 1
  7. Perl E. R., 1984, Handbook of Physiology, The Nerv. Syst. Vol. III, part 2, 915
  8. Rose M., 1927, Gyrus limbicus anterior und regio retrosplenialis (Cortex holoprotoptychos quinquestratificatus) Vergleichende Architektonik bei Tier und Mensch, J. Psychol. Neurol., (Leipzig), 35, 65
  9. Shipley M. Y., 1989, Organization of cortical inputs to rat periaqueductal gray, Soc. Neuroscience Abstr., 15, 151

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Metadata

Authors
Hurley, K. M., Herbert, H., Moga, M. M., & Saper, C. B.
Affiliations
University of Chicago (US)
Corresponding author
Saper, Clifford B.
ORCID
Saper, Clifford B.
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1991-06-08
Volume
308
Issue
2
Pages
249-276
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.903080210
OpenAlex
W2012483271
Cited by
777
References
80
Citations by year
2026: 12 · 2025: 14 · 2024: 20 · 2023: 13 · 2022: 15 · 2021: 17 · 2020: 17 · 2019: 21 · 2018: 16 · 2017: 21 · 2016: 17 · 2015: 16 · 2014: 35 · 2013: 31 · 2012: 27
FWCI
8.21
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4872 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ns022835-11, 1f31mh009607-01)
  • National Institute of Mental Health (MH09607)
  • National Institute of Neurological Disorders and Stroke (NS-22835)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
infralimbic cortex, efferent projections, thalamus, hypothalamus, amygdala, bed nucleus of the stria terminalis, corticospinal tract, nucleus accumbens, periaqueductal gray, parabrachial nucleus, nucleus tractus solitarius, nucleus ambiguus, ventrolateral medulla, intermediolateral cell column, stress response, emotion regulation, rats
MeSH terms
Animals, Autonomic Nervous System, Axonal Transport, Brain Mapping, Cerebral Cortex, Efferent Pathways, Limbic System, Medulla Oblongata, Mesencephalon, Pons, Rats, Inbred Strains, Spinal Cord, Thalamus, Lectins, Rats

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