The DOI matches its Crossref record; 251 of the 251 references it cites were found in a registry or an index.
Liver Sinusoidal Endothelial Cells
Abstract
The liver sinusoidal endothelial cell (LSEC) forms the fenestrated wall of the hepatic sinusoid and functions as a control post regulating and surveying the trafficking of molecules and cells between the liver parenchyma and the blood. The cell acts as a scavenger cell responsible for removal of potential dangerous macromolecules from blood, and is increasingly acknowledged as an important player in liver immunity. This review provides an update of the major functions of the LSEC, including its role in plasma ultrafiltration and regulation of the hepatic microcirculation, scavenger functions, immune functions, and role in liver aging, as well as issues that are either undercommunicated or confusingly dealt with in the literature. These include metabolic functions, including energy metabolic interplay between the LSEC and the hepatocyte, and adequate ways of identifying and distinguishing the cells.
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Cites
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Cited by
Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies
Claesson-Welsh, L., Dejana, E., & McDonald, D. M. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.11.006 · Cited by 631
Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity
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Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan
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Metadata
- Authors
- Sørensen, K. K., Simon‐Santamaria, J., McCuskey, R. S., & Smedsrød, B.
- Venue
- Comprehensive Physiology
- Publisher
- Wiley
- Published
- 2015-09-20
- Volume
- 5
- Issue
- 4
- Pages
- 1751-1774
- ISSN
- 2040-4603 (ISSN-L)
- OpenAlex
- W2164779038
- Cited by
- 257
- References
- 251
- Type
- other
- Language
- en
- Open access
- closed
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- Sørensen, K. K., Simon‐Santamaria, J., McCuskey, R. S., & Smedsrød, B. (2015). Liver Sinusoidal Endothelial Cells. Comprehensive Physiology. https://doi.org/10.1002/cphy.c140078
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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