Genetics of HPA-axis, depression and suicidality
Abstract
The ultimate consequence of mental ill-health, suicidal behavior (SB), is a significant problem in most societies of the world. Suicide causes about one million deaths worldwide each year, and 10-20 times more people attempt suicide. The causes of why certain people engage in SB are complex, involving for e.g., both environmental and genetic factors, and interactions in-between. Well-established environmental risk factors are events causing significant psychological stress, which are particularly difficult to cope with, e.g. exposure to physical and sexual abuse. Excessive stress have the potential to induce unfavorable effects in a variety of higher brain-functions, incurred as side-effects to maladaptive responses in the genetically controlled stress-responsive neurosystems, e.g. the hypothalamic-pituitary-adrenal (HPA) axis; a major and systemic stress-modulator, which is mainly controlled by the regulatory corticotrophin releasing hormone receptor 1 (CRHR1) gene. Variation in-between individuals in such stress-regulatory genes such as CRHR1, may underlie the causes of the increased susceptibility of certain individuals towards SB. Here we review some of the current knowledge on what is known about the roles of the HPA axis in SB, with a focus on CRHR1.
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Increased CRF concentration in cerebrospinal fluid was reported in depressive patients and victims of suicide.
“Increased CRF concentration in the cerebrospinal fluid was also reported in depressive patients and victims of suicide [359,360].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [360]
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- Authors
- Wasserman, D., Wasserman, J., & Sokolowski, M.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Wasserman, D.
- Venue
- European Psychiatry
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-06
- Volume
- 25
- Issue
- 5
- Pages
- 278-280
- ISSN
- 0924-9338 (ISSN-L)
- 1778-3585
- OpenAlex
- W1992816731
- Cited by
- 63
- References
- 33
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 8 · 2016: 6 · 2015: 5 · 2014: 9 · 2013: 5 · 2012: 12
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- hypothalamic-pituitary-adrenal axis, suicide, depression, CRHR1, corticotropin-releasing hormone receptor 1, genetic susceptibility, stress response, psychological stress, gene-environment interaction
- MeSH terms
- CRF Receptor, Type 1, Depressive Disorder, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress, Psychological, Suicide, Receptors, Corticotropin-Releasing Hormone
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